Immunoreactive neurotensin and somatostatin in the chicken thymus

1978 ◽  
Vol 194 (3) ◽  
Author(s):  
Frank Sundler ◽  
R.E. Carraway ◽  
R. H�kanson ◽  
J. Alumets ◽  
M.P. Dubois
Keyword(s):  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Liangxing Guo ◽  
Zhaokun Mu ◽  
Furong Nie ◽  
Xuanniu Chang ◽  
Haitao Duan ◽  
...  

AbstractNewcastle disease (ND), caused by virulent Newcastle disease virus (NDV), is a contagious viral disease affecting various birds and poultry worldwide. In this project, differentially expressed (DE) circRNAs, miRNAs and mRNAs were identified by high-throughput RNA sequencing (RNA-Seq) in chicken thymus at 24, 48, 72 or 96 h post LaSota NDV vaccine injection versus pre-inoculation group. The vital terms or pathways enriched by vaccine-influenced genes were tested through KEGG and GO analysis. DE genes implicated in innate immunity were preliminarily screened out through GO, InnateDB and Reactome Pathway databases. The interaction networks of DE innate immune genes were established by STRING website. Considering the high expression of gga-miR-6631-5p across all the four time points, DE circRNAs or mRNAs with the possibility to bind to gga-miR-6631-5p were screened out. Among DE genes that had the probability to interact with gga-miR-6631-5p, 7 genes were found to be related to innate immunity. Furthermore, gga-miR-6631-5p promoted LaSota NDV replication by targeting insulin induced gene 1 (INSIG1) in DF-1 chicken fibroblast cells. Taken together, our data provided the comprehensive information about molecular responses to NDV LaSota vaccine in Chinese Partridge Shank Chickens and elucidated the vital roles of gga-miR-6631-5p/INSIG1 axis in LaSota NDV replication.



2018 ◽  
Vol 120 (4) ◽  
pp. 6570-6579 ◽  
Author(s):  
Yanting Zhou ◽  
Weihua Tian ◽  
Meng Zhang ◽  
Tuanhui Ren ◽  
Guirong Sun ◽  
...  
Keyword(s):  


2004 ◽  
Vol 28 (4) ◽  
pp. 337-345 ◽  
Author(s):  
Cherie M Oubre ◽  
Xiaodong Zhang ◽  
Kathleen E Clements ◽  
Tom E Porter ◽  
Luc R Berghman


1979 ◽  
Vol 21 (3) ◽  
pp. 189-194 ◽  
Author(s):  
MASANOBU SUGIMOTO ◽  
TOMOYOSHI YASUDA ◽  
YASUYUKI EGASHIRA


1971 ◽  
Vol 134 (4) ◽  
pp. 1036-1045 ◽  
Author(s):  
W. P. McArthur ◽  
J. Chapman ◽  
G. J. Thorbecke

Specific antisera to chicken thymus and to bursa of Fabricius were obtained in rabbits. After appropriate absorption and dilution all four anti-thymus sera, in the presence of guinea pig C', killed >90% of thymus and ≦12% of bursa cells. They were cytotoxic for approximately 50% of spleen cells and did not affect antibody-forming cells. The surface antigen detected by these antisera was named chicken T-lymphocyte antigen (CTLA). Two of four anti-bursa sera, under similar conditions, killed >90% of bursa cells and ≦10% of thymus cells. These antisera were cytotoxc for a large percentage of antibody-forming cells and killed approximately 30% of spleen cells The other two anti-bursa sera were somewhat less potent but showed similar specificity. The surface antigen detected by these antisera was named chicken bursa-derived lymphocyte antigen (CBuLA). Rabbit antisera to chicken immunoglobulin were cytotoxic for bursa but not for thymus cells and killed a similar percentage of spleen cells as did anti-bursa sera. They were also cytotoxic for antibody-forming cells.



1974 ◽  
Vol 47 (3) ◽  
pp. 388-399 ◽  
Author(s):  
Jan F. Sällström ◽  
Gunnar V. Alm




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