Immunocytochemical determination of ploidy class-dependent bromodeoxyuridine incorporation in rat liver parenchymal cells after partial hepatectomy

1990 ◽  
Vol 93 (6) ◽  
pp. 627-630 ◽  
Author(s):  
W. M. Frederiks ◽  
F. Marx ◽  
R. A. F. M. Chamuleau ◽  
C. J. F. van Noorden ◽  
J. James
Keyword(s):  
Partial Hepatectomy ◽  
Rat Liver ◽  
Liver Parenchymal ◽  
Ploidy Class ◽  
Parenchymal Cells

Metabolic activity of insulin-like growth factor I on cultured rat liver parenchymal cells

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S3
Author(s):  
H. HARTMANN ◽  
S. ZACHMANN ◽  
W. CREUTZFELDT
Keyword(s):  
Growth Factor ◽  
Rat Liver ◽  
Metabolic Activity ◽  
Insulin Like Growth Factor ◽  
Liver Parenchymal ◽  
Factor I ◽  
Growth Factor I ◽  
Parenchymal Cells

scholarly journals Induction of amino acid transport in primary cultures of adult rat liver parenchymal cells by insulin.

1976 ◽  
Vol 251 (10) ◽  
pp. 3014-3020 ◽  
Author(s):  
R F Kletzien ◽  
M W Pariza ◽  
J E Becker ◽  
V R Potter ◽  
F R Butcher
Keyword(s):  
Amino Acid ◽  
Rat Liver ◽  
Amino Acid Transport ◽  
Primary Cultures ◽  
Acid Transport ◽  
Liver Parenchymal ◽  
Adult Rat ◽  
Parenchymal Cells

scholarly journals The mechanism of pantothenate transport by rat liver parenchymal cells in primary culture.

1985 ◽  
Vol 260 (8) ◽  
pp. 4823-4831
Author(s):  
C M Smith ◽  
R E Milner
Keyword(s):  
Primary Culture ◽  
Rat Liver ◽  
Liver Parenchymal ◽  
Parenchymal Cells

Ether Inhibition of Ethanol Metabolism in Isolated Rat Liver Parenchymal Cells

1981 ◽  
Vol 5 (4) ◽  
pp. 550-555 ◽  
Author(s):  
Hakon Aune ◽  
Allan R. Stowell ◽  
Jorg Morland
Keyword(s):  
Rat Liver ◽  
Ethanol Metabolism ◽  
Liver Parenchymal ◽  
Isolated Rat Liver ◽  
Parenchymal Cells ◽  
Isolated Rat

scholarly journals The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells

1989 ◽  
Vol 264 (3) ◽  
pp. 737-744 ◽  
Author(s):  
P Steinberg ◽  
H Schramm ◽  
L Schladt ◽  
L W Robertson ◽  
H Thomas ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Glutathione Peroxidase ◽  
Rat Liver ◽  
Peroxidase Activity ◽  
Cell Types ◽  
Transferase Activity ◽  
Glutathione Peroxidase Activity ◽  
Glutathione S Transferase ◽  
Liver Parenchymal ◽  
Parenchymal Cells

The distribution and inducibility of cytosolic glutathione S-transferase (EC 2.5.1.18) and glutathione peroxidase (EC 1.11.1.19) activities in rat liver parenchymal, Kupffer and endothelial cells were studied. In untreated rats glutathione S-transferase activity with 1-chloro-2,4-dinitrobenzene and 4-hydroxynon-2-trans-enal as substrates was 1.7-2.2-fold higher in parenchymal cells than in Kupffer and endothelial cells, whereas total, selenium-dependent and non-selenium-dependent glutathione peroxidase activities were similar in all three cell types. Glutathione S-transferase isoenzymes in parenchymal and non-parenchymal cells isolated from untreated rats were separated by chromatofocusing in an f.p.l.c. system: all glutathione S-transferase isoenzymes observed in the sinusoidal lining cells were also detected in the parenchymal cells, whereas Kupffer and endothelial cells lacked several glutathione S-transferase isoenzymes present in parenchymal cells. At 5 days after administration of Arocolor 1254 glutathione S-transferase activity was only enhanced in parenchymal cells; furthermore, selenium-dependent glutathione peroxidase activity decreased in parenchymal and non-parenchymal cells. At 13 days after a single injection of Aroclor 1254 a strong induction of glutathione S-transferase had taken place in all three cell types, whereas selenium-dependent glutathione peroxidase activity remained unchanged (endothelial cells) or was depressed (parenchymal and Kupffer cells). Hence these results clearly establish that glutathione S-transferase and glutathione peroxidase are differentially regulated in rat liver parenchymal as well as non-parenchymal cells. The presence of glutathione peroxidase and several glutathione S-transferase isoenzymes capable of detoxifying a variety of compounds in Kupffer and endothelial cells might be crucial to protect the liver from damage by potentially hepatotoxic substances.

Cytoplasmic proteases of rat liver parenchymal cells

1982 ◽  
Vol 108 (3) ◽  
pp. 1325-1330 ◽  
Author(s):  
George N. DeMartino
Keyword(s):  
Rat Liver ◽  
Liver Parenchymal ◽  
Parenchymal Cells
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