scholarly journals Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments

1982 ◽  
Vol 60 (1) ◽  
pp. 46-56 ◽  
Author(s):  
T. Cremer ◽  
C. Cremer ◽  
H. Baumann ◽  
E. K. Luedtke ◽  
K. Sperling ◽  
...  
Keyword(s):  
Chromosome Condensation ◽  
Premature Chromosome Condensation ◽  
Interphase Chromosome ◽  
Chromosome Arrangement

scholarly journals The use of premature chromosome condensation to study in interphase cells the influence of environmental factors on human genetic material

2006 ◽  
Vol 6 ◽  
pp. 1174-1190 ◽  
Author(s):  
Vasiliki I. Hatzi ◽  
Georgia I. Terzoudi ◽  
Christina Paraskevopoulou ◽  
Vasilios Makropoulos ◽  
Demetrios P. Matthopoulos ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Environmental Factors ◽  
Cell Cycle Progression ◽  
Genetic Material ◽  
Chromosome Condensation ◽  
Premature Chromosome Condensation ◽  
Interphase Chromosome ◽  
Diagnosis And Prognosis ◽  
Anthropogenic Environment ◽  
Genotoxic Factors

Nowadays, there is a constantly increasing concern regarding the mutagenic and carcinogenic potential of a variety of harmful environmental factors to which humans are exposed in their natural and anthropogenic environment. These factors exert their hazardous potential in humans' personal (diet, smoking, pharmaceuticals, cosmetics) and occupational environment that constitute part of the anthropogenic environment. It is well known that genetic damage due to these factors has dramatic implications for human health. Since most of the environmental genotoxic factors induce arrest or delay in cell cycle progression, the conventional analysis of chromosomes at metaphase may underestimate their genotoxic potential. Premature Chromosome Condensation (PCC) induced either by means of cell fusion or specific chemicals, enables the microscopic visualization of interphase chromosomes whose morphology depends on the cell cycle stage, as well as the analysis of structural and numerical aberrations at the G1 and G2 phases of the cell cycle. The PCC has been successfully used in problems involving cell cycle analysis, diagnosis and prognosis of human leukaemia, assessment of interphase chromosome malformations resulting from exposure to radiation or chemicals, as well as elucidation of the mechanisms underlying the conversion of DNA damage into chromosomal damage. In this report, particular emphasis is given to the advantages of the PCC methodology used as an alternative to conventional metaphase analysis in answering questions in the fields of radiobiology, biological dosimetry, toxicogenetics, clinical cytogenetics and experimental therapeutics.

scholarly journals On emerging nuclear order

2011 ◽  
Vol 192 (5) ◽  
pp. 711-721 ◽  
Author(s):  
Indika Rajapakse ◽  
Mark Groudine
Keyword(s):  
Nuclear Organization ◽  
Chromatin State ◽  
Interphase Chromosome ◽  
Chromosome Arrangement ◽  
Technological Advances ◽  
Genome Wide ◽  
Nuclear Processes ◽  
Genomic Function

Although the nonrandom nature of interphase chromosome arrangement is widely accepted, how nuclear organization relates to genomic function remains unclear. Nuclear subcompartments may play a role by offering rich microenvironments that regulate chromatin state and ensure optimal transcriptional efficiency. Technological advances now provide genome-wide and four-dimensional analyses, permitting global characterizations of nuclear order. These approaches will help uncover how seemingly separate nuclear processes may be coupled and aid in the effort to understand the role of nuclear organization in development and disease.

Isochromosome i(3q) and premature chromosome condensation are recurrent findings in chronic b-cell lymphocytosis with binucleated lymphocytes

1996 ◽  
Vol 20 (3-4) ◽  
pp. 267-273 ◽  
Author(s):  
H. Mossafa ◽  
X. Troussard ◽  
F. Valensi ◽  
F. Schillinger ◽  
M. Maynadie ◽  
...  
Keyword(s):  
B Cell ◽  
Chromosome Condensation ◽  
Premature Chromosome Condensation ◽  
Binucleated Lymphocytes
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