The human gene encoding insulin-like growth factor I is located on chromosome 12

1985 ◽  
Vol 69 (2) ◽  
pp. 157-160 ◽  
Author(s):  
J. W. M. Höppener ◽  
P. de Pagter-Holthuizen ◽  
A. H. M. Geurts van Kessel ◽  
M. Jansen ◽  
S. D. Kittur ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Gene ◽  
Chromosome 12 ◽  
Insulin Like Growth Factor ◽  
Gene Encoding ◽  
Factor I ◽  
Growth Factor I

scholarly journals Enhanced Production of Insulin-Like Growth Factor I Fusion Protein in Escherichia coli by Coexpression of the Down-Regulated Genes Identified by Transcriptome Profiling

2003 ◽  
Vol 69 (8) ◽  
pp. 4737-4742 ◽  
Author(s):  
Jong Hyun Choi ◽  
Sang Jun Lee ◽  
Seok Jae Lee ◽  
Sang Yup Lee
Keyword(s):  
Escherichia Coli ◽  
Growth Factor ◽  
Fusion Protein ◽  
Transcriptome Profiling ◽  
Insulin Like Growth Factor ◽  
Gene Encoding ◽  
Factor I ◽  
Enhanced Production ◽  
Igf I ◽  
Growth Factor I

ABSTRACT The transcriptome profiles of recombinant Escherichia coli producing human insulin-like growth factor I fusion protein (IGF-If) during the high-cell-density fed-batch culture were analyzed using DNA microarrays. The expression levels of 529 genes were significantly altered after induction. About 200 genes were significantly down-regulated during the production of IGF-If after induction. Among these down-regulated genes, we rationally selected and coexpressed in E. coli producing IGF-If the prsA gene (encoding a phosphoribosyl pyrophosphate synthetase) and the glpF gene (encoding a glycerol transporter), which are involved in an early key step in the biosynthetic pathway of nucleotides and amino acids (Trp and His) and the first step in glycerol utilization, respectively. As a result, the production of IGF-If could be increased from 1.8 ± 0.13 (± standard deviation) to 4.3 ± 0.24 g/liter. The volumetric productivity was also increased from 0.36 ± 0.027 to 0.82 ± 0.048 g/liter/h. These results demonstrate that transcriptome profiling can provide invaluable information in designing engineered strains showing enhanced performance.

scholarly journals Eco RV RFLP at the insulin-like growth factor I (IGF I) locus on chromosome 12

1988 ◽  
Vol 16 (18) ◽  
pp. 9059-9059 ◽  
Author(s):  
H. Schneid ◽  
P. Noguiez ◽  
F. Girard ◽  
M. Binoux ◽  
Y. Le Bouc
Keyword(s):  
Growth Factor ◽  
Chromosome 12 ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

Localization of the gene encoding insulin-like growth factor I on mouse Chromosome 10

1991 ◽  
Vol 56 (1) ◽  
pp. 57-58 ◽  
Author(s):  
B.A. Taylor ◽  
D. Grieco
Keyword(s):  
Growth Factor ◽  
Mouse Chromosome ◽  
Insulin Like Growth Factor ◽  
Chromosome 10 ◽  
Gene Encoding ◽  
Factor I ◽  
Growth Factor I

scholarly journals Expression of a synthetic gene encoding human insulin-like growth factor I in cultured mouse fibroblasts.

1987 ◽  
Vol 84 (9) ◽  
pp. 2638-2642 ◽  
Author(s):  
M. L. Bayne ◽  
M. A. Cascieri ◽  
B. Kelder ◽  
J. Applebaum ◽  
G. Chicchi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Human Insulin ◽  
Synthetic Gene ◽  
Insulin Like Growth Factor ◽  
Gene Encoding ◽  
Mouse Fibroblasts ◽  
Factor I ◽  
Growth Factor I

Characteristics and reference ranges of Insulin-Like Growth Factor-I measured with a commercially available immunoassay in 724 healthy adult Caucasians

2009 ◽  
pp. 1-6 ◽  
Author(s):  
Mikkel Andreassen ◽  
Kaspar Nielsen ◽  
Ilan Raymond ◽  
Lars Østergaard Kristensen ◽  
Jens Faber
Keyword(s):  
Growth Factor ◽  
Healthy Adult ◽  
Reference Ranges ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Utility of Measuring Insulin-Like Growth Factor-I for Assessing Military Operational Stress: Supporting Future Force Warrior from the Bench Top to the Battlefield

2004 ◽  
Author(s):  
B.C. Nindl ◽  
A.P. Tuckow ◽  
J.A. Alemany ◽  
T.T. Welsh ◽  
K.R. Rarick ◽  
...  
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Operational Stress ◽  
Factor I ◽  
Growth Factor I

The role of insulin receptor and insulin-like growth factor I receptor in pancreatic ductal adenocarcinoma

2013 ◽  
Vol 51 (08) ◽  
Author(s):  
E Kalideris ◽  
B Grüner ◽  
M Trajkovic-Arsic ◽  
P Mazur ◽  
RM Schmid ◽  
...  
Keyword(s):  
Growth Factor ◽  
Insulin Receptor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I
Sign in / Sign up

Export Citation Format

Share Document