Introduction: Oligoclonal bands are the result of the synthesis of antibodies of limited
heterogeneity, that is, directed against one or more specific antigens. Their detection is an
important element in the diagnosis of autoimmune diseases. In multiple sclerosis, the
diagnostic sensitivity of the determination of oligoclonal bands is high.
Aim: The aim of this study is to answer the question whether the detection of oligoclonal
bands a more valuable study is than the Tibbling-Link index and reibergram analysis in the
context of the diagnosis of multiple sclerosis.
Material and methods: Oligoclonal bands were tested in the cerebrospinal fluid and
serum from 9 patients suspected of multiple sclerosis using the Sebia HYDRAGEL 3 CSF
ISOFOCUSING kit.
Results: In 7 out of 9 patients the Tibbling-Link index, reibergram analysis and oligoclonal
bands detection clearly indicated intrathecal IgG synthesis. In 2 of 9 patients, detection of
oligoclonal bands indicated intrathecal IgG synthesis and the value of Tibbling-Link index
and reibergram analysis did not indicated intrathecal IgG production or these tests indicated
limit values.
Conclusions: The detection of oligoclonal bands in many cases allows for faster diagnosis
and introduction of therapy. This test should be an integral part of SM diagnostics.