Maternal inheritance of mitochondrial DNA in sexual crosses of Pythium sylvaticumm

Fifteen interspecific hybrids of Serbian spruce (Piceaomorika (Panc) Purkyne) and white spruce (Piceaglauca (Moench) Voss) representing five separate crosses, including reciprocals, were used to demonstrate maternal inheritance of mitochondrial DNA. Total DNA was extracted from foliage samples of Serbian spruce (S), white spruce (W), and both S(♂) × W(♀) and W(♂) × S(♀) hybrids, digested and probed with one of two maize mitochondrial genes, ATPaseα or COXII. ATPaseα generated diagnostic Serbian and white spruce genotypes for all five enzymes tested, while COXII differentiated between the two species for four of five enzymes. Maternal inheritance was indicated in all hybrids for every diagnostic enzyme–probe combination. No paternal or nonparental bands were detected. A dilution experiment indicated that the Serbian and white spruce mitochondrial DNA restriction fragment length polymorphisms could be detected in as little as 60 and 500 ng of total DNA, respectively. It appears that the mechanism that controls the inheritance of mitochondria in Picea is still functional in wide interspecific crosses.

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Demonstration of the maternal inheritance of avian mitochondrial DNA in chicken-quail hybrids

Journal of Experimental Zoology ◽

10.1002/jez.1402360215 ◽

1985 ◽

Vol 236 (2) ◽

pp. 245-247 ◽

Cited By ~ 11

Author(s):

T. Watanabe ◽

M. Mizutani ◽

S. Wakana ◽

T. Tomita

Keyword(s):

Mitochondrial Dna ◽

Maternal Inheritance

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A pilot study of mitochondrial DNA point mutation A3243G in a sample of Croatian patients having type 2 diabetes mellitus associated with maternal inheritance

Acta Diabetologica ◽

10.1007/s00592-004-0163-x ◽

2004 ◽

Vol 41 (4) ◽

pp. 179-184 ◽

Cited By ~ 8

Author(s):

I. Martin-Kleiner ◽

E. Pape-Medvidović ◽

I. Pavlić-Renar ◽

Ž. Metelko ◽

R. Kušec ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Mitochondrial Dna ◽

Pilot Study ◽

Point Mutation ◽

Maternal Inheritance

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Inheritance of mitochondrial DNA in sexual crosses and protoplast cell fusions in Lentinula edodes

Current Genetics ◽

10.1007/bf00314446 ◽

1995 ◽

Vol 27 (6) ◽

pp. 550-554 ◽

Cited By ~ 23

Author(s):

Masaki Fukuda ◽

Yukiko Harada ◽

Satoko Imahori ◽

Yukitaka Fukumasa-Nakai ◽

Yasuo Hayashi

Keyword(s):

Mitochondrial Dna ◽

Lentinula Edodes ◽

Sexual Crosses ◽

Cell Fusions

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Maternal inheritance of mitochondria: multipolarity, multiallelism and hierarchical transmission of mitochondrial DNA in the true slime mold Physarum polycephalum

Journal of Plant Research ◽

10.1007/s10265-009-0298-5 ◽

2010 ◽

Vol 123 (2) ◽

pp. 139-148 ◽

Cited By ~ 12

Author(s):

Yohsuke Moriyama ◽

Shigeyuki Kawano

Keyword(s):

Mitochondrial Dna ◽

Physarum Polycephalum ◽

Maternal Inheritance ◽

Slime Mold

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Biparental Inheritance of Mitochondrial DNA in Humans

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1810946115 ◽

2018 ◽

Vol 115 (51) ◽

pp. 13039-13044 ◽

Cited By ~ 139

Author(s):

Shiyu Luo ◽

C. Alexander Valencia ◽

Jinglan Zhang ◽

Ni-Chung Lee ◽

Jesse Slone ◽

...

Keyword(s):

Mitochondrial Dna ◽

Maternal Inheritance ◽

Clinical Laboratory ◽

Sequencing Analysis ◽

Considerable Debate ◽

Accredited Laboratories ◽

Inheritance Mode ◽

High Level ◽

Clinical Laboratory Improvement Amendments ◽

High Depth

Although there has been considerable debate about whether paternal mitochondrial DNA (mtDNA) transmission may coexist with maternal transmission of mtDNA, it is generally believed that mitochondria and mtDNA are exclusively maternally inherited in humans. Here, we identified three unrelated multigeneration families with a high level of mtDNA heteroplasmy (ranging from 24 to 76%) in a total of 17 individuals. Heteroplasmy of mtDNA was independently examined by high-depth whole mtDNA sequencing analysis in our research laboratory and in two Clinical Laboratory Improvement Amendments and College of American Pathologists-accredited laboratories using multiple approaches. A comprehensive exploration of mtDNA segregation in these families shows biparental mtDNA transmission with an autosomal dominantlike inheritance mode. Our results suggest that, although the central dogma of maternal inheritance of mtDNA remains valid, there are some exceptional cases where paternal mtDNA could be passed to the offspring. Elucidating the molecular mechanism for this unusual mode of inheritance will provide new insights into how mtDNA is passed on from parent to offspring and may even lead to the development of new avenues for the therapeutic treatment for pathogenic mtDNA transmission.

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