scholarly journals Effects of exogenous hormones and glucose on plasma levels and hepatic metabolism of amino acids in the fetus and in the newborn rat

Diabetologia ◽  
1976 ◽  
Vol 12 (4) ◽  
pp. 327-337 ◽  
Author(s):  
J. R. Girard ◽  
I. Guillet ◽  
J. Marty ◽  
R. Assan ◽  
E. B. Marliss
Keyword(s):  
Amino Acids ◽  
Plasma Levels ◽  
Hepatic Metabolism ◽  
Newborn Rat ◽  
Exogenous Hormones

Correlations between plasma levels of amino acids and nonmotor symptoms in Parkinson’s disease

2014 ◽  
Vol 122 (3) ◽  
pp. 411-417 ◽  
Author(s):  
Qing Tong ◽  
Qinrong Xu ◽  
Qiang Xia ◽  
Yongsheng Yuan ◽  
Li Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Amino Acids ◽  
Parkinson's Disease ◽  
Plasma Levels ◽  
Nonmotor Symptoms

scholarly journals Alterations in Plasma Levels of Amino Acids after Intracerebroventricular Administration of L-Serine or D-Serine in Conscious and Freely Moving Rats

2008 ◽  
Vol 1 (1) ◽  
pp. 22-26
Author(s):  
Yuko Fujita ◽  
Tamaki Ishima ◽  
Mao Horio ◽  
Hiroko Hagiwara ◽  
Masaomi Iyo ◽  
...  
Keyword(s):  
Amino Acids ◽  
Plasma Levels ◽  
Intracerebroventricular Administration ◽  
Freely Moving Rats ◽  
Freely Moving

Can dietary intake influence plasma levels of amino acids in liver cirrhosis?

2000 ◽  
Vol 32 (7) ◽  
pp. 611-616 ◽  
Author(s):  
C. Loguercio ◽  
F. Del Vecchio Blanco ◽  
A. Nastasi ◽  
A. Federico ◽  
G. Del Vecchio Blanco ◽  
...  
Keyword(s):  
Amino Acids ◽  
Liver Cirrhosis ◽  
Dietary Intake ◽  
Plasma Levels

Utilization of amino acids by pre-ruminant lambs. III.* The influence of age and the dietary proportions of essential and non-essential amino acids on the levels of urea, ammonia and free amino acids in the blood plasma of milk-fed lambs

1978 ◽  
Vol 29 (1) ◽  
pp. 145 ◽  
Author(s):  
H Dove
Keyword(s):  
Amino Acids ◽  
Plasma Levels ◽  
Free Amino Acids ◽  
Free Amino ◽  
Essential Amino Acids ◽  
High Plasma ◽  
Whole Milk ◽  
Wide Range ◽  
Pattern Characteristic ◽  
Pre Treatment

Jugular blood samples were obtained from 10.5 kg and 28 kg lambs receiving a diet of reconstituted cows' whole milk. The lambs were then given diets in which the proportion of essential amino acids (BAA) in the dietary crude protein was altered over a wide range. A second blood sample was taken after lambs had received such diets for 12 days. Plasma obtained from these samples was analysed for free amino acids, urea and ammonia. The pattern of plasma free amino acids (PFAA) in lambs given reconstituted cows' whole milk is described. In both the pre-treatment and post-treatment samples, the heavier lambs appeared to have lower plasma levels of all EAA, and high plasma levels of glycine, serine, urea and ammonia. In the lighter lambs, there were pronounced responses of PFAA levels to changes in the dietary proportion of EAA. At low proportions, the levels of most EAA in plasma were low. Lysine and phenylalanine were exceptions. In addition, levels of many non-essential amino acids (non-EAA), particularly serine and glycine, were high. At high proportions of EAA, plasma levels of all EAA, especially methionine, rose markedly. Within the non-EAA, serine, proline and glycine were reduced, while taurine and cystathionine increased. In the plasma of the heavier lambs, the response of some amino acids to a given dietary change differed from the response in the lighter lambs. This was especially true of methionine, tyrosine, phenylalanine and arginine. There was also marked between-animal variation in plasma levels. When expressed as molar proportions of total PFAA, results were similar to those of the lighter lambs. There was a pronounced similarity between the response of the PFAA to diets with a low proportion of EAA, and the PFAA pattern characteristic of developing kwashiorkor. __________________ *Part II, Aust. J. Agric. Res., 28, 933 (1977).

Free Plasma Levels and Urinary Excretion of Eighteen Amino Acids in Normal and Diabetic Dogs

1951 ◽  
Vol 167 (1) ◽  
pp. 182-192 ◽  
Author(s):  
John H. Ivy ◽  
Muriel Svec ◽  
Smith Freeman
Keyword(s):  
Amino Acids ◽  
Urinary Excretion ◽  
Plasma Levels ◽  
Diabetic Dogs ◽  
Free Plasma

scholarly journals Amino Acid Metabolism in Friedreich's Ataxia

1976 ◽  
Vol 3 (4) ◽  
pp. 373-378 ◽  
Author(s):  
B. Lemieux ◽  
A. Barbeau ◽  
V. Beroniade ◽  
D. Shapcott ◽  
G. Breton ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aspartic Acid ◽  
Plasma Levels ◽  
Genetic Defect ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Physiological Importance ◽  
And Control ◽  
Csf Concentration

SUMMARY:A study of amino acids determined by sequential Multi-sample Amino Acid Automatic Analyzer in plasma, urine and cerebrospinal fluid (CSF) in patients with Friedreich's ataxia and control subjects has revealed a number of mathematically significant variations from normal. Of practical physiological importance are the following: a high urinary excretion of alanine with slightly elevated plasma levels; a low plasma and CSF concentration of aspartic acid in the resence of normal urinary values and finally a low CSF concentration of taurine accompanied by normal plasma levels, but elevated urinary output and renal clearance rates. We postulate that the modifications in alanine and aspartic acid are less specific and probably secondary, but there could be a genetic defect in the membrane transport of taurine and the other β-amino acids in Friedreich's ataxia.

Blood-brain transport of tryptophan and phenylalanine: effect of portacaval shunt in dogs

1981 ◽  
Vol 241 (2) ◽  
pp. G163-G169
Author(s):  
P. M. Huet ◽  
G. Pomier-Layrargues ◽  
L. Duguay ◽  
P. du Souich
Keyword(s):  
Amino Acids ◽  
Plasma Levels ◽  
Aromatic Amino Acids ◽  
Portacaval Shunt ◽  
Molar Ratio ◽  
Brain Uptake ◽  
Sagittal Sinus ◽  
Plasma Phenylalanine ◽  
Blood Brain ◽  
Uptake Process

The blood-brain uptake process for tryptophan and phenylalanine was investigated using the multiple-indicator dilution technique in 13 unanesthetized dogs with and without portacaval shunts. Tracer doses of labeled albumin (extracellular reference) and tryptophan or phenylalanine, prepared in autologous dog plasma, were injected into one carotid artery, and dorsal sagittal sinus dilution curves were obtained. Portacaval shunting was not associated with significant changes in the initial brain uptake ratio U for tryptophan or phenylalanine, despite increases in plasma phenylalanine and tyrosine. In the 13 dogs, U was not significantly correlated with the plasma levels of either the different branched-chain or aromatic amino acids or the molar ratio between these groups. These findings do not support the current hypothesis that the active transport of aromatic amino acids across the blood-brain barrier is increased after portacaval shunt. Our data suggest, instead, that the blood-brain uptake process for aromatic amino acids is linear and increases in shunted animals because their plasma levels are increased.

scholarly journals Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels

2001 ◽  
Vol 85 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Rohan M. Lewis ◽  
Lynwen A. James ◽  
Junlong Zhang ◽  
Christopher D. Byrne ◽  
C. Nicholas Hales
Keyword(s):  
Amino Acids ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Plasma Levels ◽  
Plasma Cholesterol ◽  
Maternal Plasma ◽  
Fetal Growth Retardation ◽  
Restricted Diet ◽  
Fetal Plasma ◽  
Restricted Group

The mechanism by which maternal Fe deficiency in the rat causes fetal growth retardation has not been clearly established. This study compared the effects on the fetuses from dams fed a control diet with two groups of dams fed Fe-restricted diets. One Fe-restricted group was fed the Fe-restricted diet for 1 week prior to mating and throughout gestation and the second Fe-restricted group was fed the Fe-restricted diet for 2 weeks prior to mating and throughout gestation. On day 21 of gestation Fe-restricted dams, and their fetuses, were anaemic. Fetal weight was reduced in both Fe-restricted groups compared with controls. Expression of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) are induced by hypoxia. The levels of HIF-1α mRNA were highest in placenta, then in kidney, heart and liver but were not different between the groups. Levels of plasma VEGF were not different between the groups. Maternal plasma triacylglycerol was decreased in the 1-week Fe-restricted dams compared with controls. Maternal plasma cholesterol and free fatty acid levels were not different between the groups. In fetal plasma, levels of triacylglycerol and cholesterol were decreased in both Fe-restricted groups. In maternal plasma, levels of a number of amino acids were elevated in both Fe-restricted groups. In contrast, levels of a number of amino acids in fetal plasma were lower in both Fe-restricted groups. Fetal plasma lactate was increased in Fe-restricted fetuses but fetal plasma glucose and β-hydroxybutyrate were not affected. These changes in fetal metabolism may contribute to fetal growth retardation in this model. This study does not support the hypothesis that the Fe-restricted fetus is hypoxic.

Effect of plasma levels of large neutral amino acids and degree of parkinsonism on the blood-to-brain transport of levodopa in naive and MPTP parkinsonian monkeys

Neurology ◽  
1994 ◽  
Vol 44 (8) ◽  
pp. 1491-1491 ◽  
Author(s):  
G. M. Alexander ◽  
R. J. Schwartzman ◽  
J. R. Grothusen ◽  
S. W. Gordon
Keyword(s):  
Amino Acids ◽  
Plasma Levels ◽  
Large Neutral Amino Acids ◽  
Neutral Amino Acids
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