Long-term treatment of central precocious puberty with an intranasal LHRH analogue: control of pituitary function by urinary gonadotropins

1988 ◽  
Vol 147 (3) ◽  
pp. 263-269 ◽  
Author(s):  
J. -L. Rime ◽  
U. Zumsteg ◽  
A. Blumberg ◽  
F. Hadziselimovic ◽  
J. Girard ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Term Treatment ◽  
Pituitary Function ◽  
Lhrh Analogue ◽  
Long Term Treatment

scholarly journals Final height in central precocious puberty after long term treatment with a slow release GnRH agonist.

1996 ◽  
Vol 75 (4) ◽  
pp. 292-297 ◽  
Author(s):  
W Oostdijk ◽  
B Rikken ◽  
S Schreuder ◽  
B Otten ◽  
R Odink ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Gnrh Agonist ◽  
Slow Release ◽  
Final Height ◽  
Central Precocious Puberty ◽  
Term Treatment ◽  
Long Term Treatment

Long-Term Treatment of Central Precocious Puberty with a Long-Acting Analogue of Luteinizing Hormone-Releasing Hormone

1983 ◽  
Vol 309 (21) ◽  
pp. 1286-1290 ◽  
Author(s):  
M.Joan Mansfield ◽  
Donna E. Beardsworth ◽  
Jacquelyn S. Loughlin ◽  
John D. Crawford ◽  
Hans H. Bode ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Term Treatment ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Long Term Treatment ◽  
Long Acting

scholarly journals Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats

2006 ◽  
Vol 189 (1) ◽  
pp. 77-88 ◽  
Author(s):  
Martina Böttner ◽  
Julie Christoffel ◽  
Hubertus Jarry ◽  
Wolfgang Wuttke
Keyword(s):  
Serum Levels ◽  
Term Treatment ◽  
Prolactin Secretion ◽  
Gnrh Receptor ◽  
Female Rats ◽  
Pituitary Function ◽  
Ovx Rats ◽  
Long Term Treatment

Hormone replacement therapy (HRT) has been used for several decades to treat menopausal discomforts. However, in the light of recent studies that draw attention to the potential hazards of conventional HRT, various attempts have been undertaken to search for alternatives to classical HRT. Phytoestrogens are claimed to be capable of positively influencing menopausal symptoms, including hot flushes. We designed a long-term study of 3 months to assess the effects of subcutaneous and orally fed 17β-estradiol (E2), as well as the actions of resveratrol (RES) on pituitary function in female rats. Our results have demonstrated that RES binds with a 10-fold lower affinity to estrogen receptor (ER)-α than to ERβ. The data from the in vivo study revealed that a dosage of 5 μg and 50 μg RES/kg bodyweight per day given to ovariectomized (OVX) rats achieved serum levels of 1.0 and 8.1 μM respectively. Long-term treatment of OVX rats with RES revealed no estrogenic potential on pituitary function in vivo as assessed by LH and prolactin secretion and by regulation of mRNAs for LHα, LHβ, and GnRH receptor. Subcutaneous treatment with E2 in silastic capsules exerted stronger effects on LH and prolactin secretion, as well as on LHβ, LHα, GnRH receptor, and ERβ mRNA regulation compared with orally applied estradiol benzoate despite comparable serum levels. Levels of aryl hydrocarbon receptor (AhR) mRNA in the pituitary were increased following OVX and attenuated by long-term E2 treatment, whereas RES did not modulate AhR mRNA expression.

scholarly journals DIFFERENTIAL EFFECT OF D-TRP-6-LH-RH IN MICROCAPSULES (LRH-M) UPON LH AND LHα RELEASE DURING LONG TERM TREATMENT OF PRECOCIOUS PUBERTY (PP)

1986 ◽  
Vol 20 (11) ◽  
pp. 1179-1179 ◽  
Author(s):  
N Lahlou ◽  
J L Chaussain ◽  
A M Piot ◽  
M Roger ◽  
J E Toublanc ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Differential Effect ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Lh Rh

Long-term treatment of familial male-limited precocious puberty (testotoxicosis) with cyproterone acetate or ketoconazole

2008 ◽  
Vol 69 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Madson Queiroz Almeida ◽  
Vinicius Nahime Brito ◽  
Thereza Selma S. Lins ◽  
Gil Guerra-Junior ◽  
Margaret de Castro ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Cyproterone Acetate ◽  
Term Treatment ◽  
Long Term Treatment
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