Bioavailability of sodium valproate suppositories during repeated administration at steady state in epileptic children

1987 ◽  
Vol 146 (4) ◽  
pp. 404-407 ◽  
Author(s):  
J. Issakainen ◽  
B. F. D. Bourgeois
Keyword(s):  
Steady State ◽  
Sodium Valproate ◽  
Repeated Administration ◽  
Epileptic Children

Effect of Long-Term Therapy with Sodium Valproate on Nail and Serum Trace Element Status in Epileptic Children

2004 ◽  
Vol 102 (1-3) ◽  
pp. 001-010 ◽  
Author(s):  
Ferah Armutcu ◽  
Elif Ozerol ◽  
Ahmet Gurel ◽  
Mehmet Kanter ◽  
Huseyin Vural ◽  
...  
Keyword(s):  
Trace Element ◽  
Sodium Valproate ◽  
Term Therapy ◽  
Trace Element Status ◽  
Epileptic Children ◽  
Serum Trace Element ◽  
Long Term Therapy

Transient Decrease in Serum Albumin Concentrations in Epileptic Children Treated With Sodium Valproate Monotherapy

2007 ◽  
Vol 30 (3) ◽  
pp. 145-149 ◽  
Author(s):  
Achilleas Attilakos ◽  
Konstantinos A. Voudris ◽  
Eustathia Katsarou ◽  
Alexia Prassouli ◽  
Sotiria Mastroyianni ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Sodium Valproate ◽  
Transient Decrease ◽  
Epileptic Children

Early and persistent increase in serum lipoprotein (a) concentrations in epileptic children treated with carbamazepine and sodium valproate monotherapy

2006 ◽  
Vol 70 (2-3) ◽  
pp. 211-217 ◽  
Author(s):  
Konstantinos A. Voudris ◽  
Achilleas Attilakos ◽  
Eustathia Katsarou ◽  
Antonios Drakatos ◽  
Stamatia Dimou ◽  
...  
Keyword(s):  
Sodium Valproate ◽  
Serum Lipoprotein ◽  
Lipoprotein A ◽  
Epileptic Children

Generic Substitution and Bioequivalence of Sodium Valproate at Steady-State in Healthy Volunteers

2008 ◽  
Vol 25 (3) ◽  
pp. 183-195
Author(s):  
Tanvir K. Gill ◽  
Ashish R. Agrawal ◽  
Muzaffar Iqbal ◽  
Tausif Monif ◽  
P.L. Sharma
Keyword(s):  
Steady State ◽  
Healthy Volunteers ◽  
Sodium Valproate ◽  
Generic Substitution

Daily Variations in Steady-State Plasma Concentrations of Carbamazepine and its Metabolites in Epileptic Children

1991 ◽  
Vol 20 (3) ◽  
pp. 237-244 ◽  
Author(s):  
Ronald Hartley ◽  
W. Ian Forsythe ◽  
Bruce McLain ◽  
Pak C. Ng ◽  
Mark D. Lucock
Keyword(s):  
Steady State ◽  
Plasma Concentrations ◽  
Daily Variations ◽  
Epileptic Children ◽  
State Plasma

Serum and Muscle Carnitine Levels in Epileptic Children Receiving Sodium Valproate

2009 ◽  
Vol 24 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Murat Anil ◽  
Mehmet Helvaci ◽  
Ebru Ozbal ◽  
Onder Kalenderer ◽  
Ayse Berna Anil ◽  
...  
Keyword(s):  
Sodium Valproate ◽  
Epileptic Children

scholarly journals Association of long term sodium valproate monotherapy and vitamin D3 levels in epileptic children

2021 ◽  
Vol 25 (1) ◽  
pp. 117-121
Author(s):  
Anum Shah ◽  
Imran Mahmood Khan ◽  
Sajid Hussain Sherazi ◽  
Taniah Ashfaq ◽  
Sajid Hussain Shah
Keyword(s):  
Vitamin D ◽  
Sodium Valproate ◽  
Vitamin D3 ◽  
Demographic Data ◽  
Serum Vitamin ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Epileptic Children ◽  
Vitamin D3 Deficiency

Objective: To determine the association of long term sodium valproate monotherapy and vitamin D3 levels in epileptic children Methods: This cross-sectional study was conducted in the Department of Pediatrics, Children Hospital, Pakistan Institute of Medical Sciences, Islamabad for six months from 15th February 2019 to 14th August 2019. A total of one hundred and thirty (n=130) children and adolescents of either gender between age 3-18 years who had a history of two seizures at least 24 hours apart in their life and were on sodium valproate monotherapy for more than one year were enrolled in this study through non-probability, consecutive sampling. Serum vitamin D3 (25-hydroxy vitamin D) levels were measured in all the patients at the time of enrolment into the study. All the demographic data and laboratory investigations were entered on the predesigned proforma and analyzed through SPSS version 17. Results: Vitamin D3 deficiency was found in 47 (36.2%) children which were significantly higher among patients with older age and longer duration of treatment (P<0.05) while gender and BMI of the patients did not show any significant difference (P>0.05). Conclusion: Significant percentage of epileptic children on sodium valproate monotherapy was found to have vitamin D3 deficiency. Therefore we recommend routine screening of vitamin D3 deficiency in all the epileptic children on long-term sodium valproate therapy followed by vitamin D supplementation in deficient patients.  

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