Exchange of the amino group in ?-amino derivatives of sulfolane

1974 ◽  
Vol 10 (5) ◽  
pp. 538-540
Author(s):  
T. �. Bezmenova ◽  
P. G. Dul'nev
Keyword(s):  
Amino Group ◽  
Amino Derivatives ◽  
Derivatives Of

Sulphonamides. IV. The Reaction of N-Heterocyclic Amines with Sulphonyl Halides

1952 ◽  
Vol 5 (2) ◽  
pp. 374
Author(s):  
SJ Angyal
Keyword(s):  
Heterocyclic Amines ◽  
Amino Group ◽  
Ring Nitrogen ◽  
Amino Derivatives ◽  
Cyclic Compounds ◽  
Derivatives Of

The hypothesis is advanced that the reaction of sulphonyl halides with amino-derivatives of nitrogen-containing cyclic compounds occurs on the ring-nitrogen (which is the more basic), followed either by reaction of the amino-group with another molecule of sulphonyl halide, or by migration of the sulphonyl group from the ring to the ammo-nitrogen. Several apparently anomalous cases of this reaction are explained.

scholarly journals The antiseptic and trypanocidal action of some benzoylamino quinoline anil and styryl compounds

1933 ◽  
Vol 113 (783) ◽  
pp. 300-307 ◽  
Keyword(s):  
Inhibitory Concentration ◽  
Protein Solutions ◽  
Amino Group ◽  
Peptone Water ◽  
High Dilutions ◽  
Tertiary Amino ◽  
Amino Derivatives ◽  
Derivatives Of ◽  
Very High ◽  
Close Parallel

The antiseptic and trypanocidal properties of certain amino derivatives of 2-styryl quinoline have already been dealt with. Hitherto the substituent groups in the quinoline nucleus have been chiefly in the 6-position (Occasionally the 4-or 7-position) and have consisted of primary or tertiary amino, acyl-amino or carboxylamino groups. In the present series the 6-position is occupied by a primary, tertiary or acetylated para amino benzoylamino group. The methods of estimating antiseptic and trypanocidal action correspond with those previously used. The results are given in Table I. For reasons already stated (Ashley and others, p. 293), the antiseptic potency is represented by the inhibitory concentration of the substances. The anils in which the 6-amino group of the quinoline nucleus is arylated (Nos. 73, 422, 421) are all very powerfully antiseptic toward both staphylococcus and B. coli . In this respect they resemble the 2 p -dimethylamino anils in which the 6-position in the quinoline nucleus is occupied by an acyl-amino group (Nos. 59-69). Several of the styryl compounds also are fairly active antiseptics both for staphylococcus and B. coli . especially Nos. 426. 430. On comparing their effects with those of the non-benzoylated analogues bearing the same terminal groups in the side-chains, it appears that there is no close parallel between structure and action in the two series— of . Nos. 245, 87, 427, 21; 426, 24; 437, 90. Several of the benzoylamino compounds even in very high dilutions are precipitated in protein solutions (peptone water, serum); this is especially so with No. 430 and, to a less extent, with Nos. 421, 437, 422 and 245.

Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their Derived Glycosides

2019 ◽  
Vol 19 (13) ◽  
pp. 1093-1110 ◽  
Author(s):  
Adel A.H. Abdel Rahman ◽  
Ibrahim F. Nassar ◽  
Amira K.F. Shaban ◽  
Dina S. EL-Kady ◽  
Hanem M. Awad ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Human Liver ◽  
Docking Studies ◽  
Cyclin Dependent Kinase ◽  
Binding Interaction ◽  
Enzyme Active Site ◽  
Human Liver Cancer ◽  
Amino Derivatives ◽  
Activity Behavior ◽  
Derivatives Of

Background & Objective:New diaryl-substituted pyrimidinedione compounds, their thioxo derivatives as well as their bicyclic thiazole compounds were synthesized and characterized.Methods:The glycosylamino derivatives of the synthesized disubstituted derivatives of the pyrimidine scaffold were also prepared via reaction of the N3-amino derivatives with a number of monosaccharides followed by acetylation.Results:The anticancer activity of the synthesized compounds was studied against human liver cancer (HepG2) and RPE-1cell lines. Compounds 2a, 2b, 3a and 12 showed potent activities with IC50 results comparable to that of doxorubicin.Conclusion:Docking investigations into Cyclin-dependent kinase 2 (CDK-2) enzyme, a potential target for cancer medication, were also reported showing the possible binding interaction into the enzyme active site to support their activity behavior.

Thermal cyclocondensations of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino derivatives of 2-propenoic acid

1987 ◽  
Vol 52 (12) ◽  
pp. 2918-2925 ◽  
Author(s):  
Viktor Milata ◽  
Dušan Ilavský
Keyword(s):  
Uv Spectra ◽  
Propenoic Acid ◽  
Amino Derivatives ◽  
Derivatives Of ◽  
C Nmr ◽  
Ir And Uv Spectra

The cyclization of 3-N(4- and 5-benzimidazolyl and benztriazolyl)amino-2-cyano- and 2-ethoxycarbonyl-2-propenoate esters Ia, b-IVa, b under the conditions of the Gould-Jacobs reaction leads to angularly ring-fused substituted imidazo or triazolo[4,5-f] (V, VI) and [4,5-h] (VII, VIII) quinolines, respectively. The esters Vb-VIIIb have been transformed into the corresponding chloroderivatives Vc-VIIIc. 3-N(5-Benzimidazolyl and 5-benztriazolyl)amino-2-cyano-2-propenenitriles are cyclized in the presence of aluminium(III) chloride to give the aminoquinolines Vd, VId. The structure of the products has been characterized by their 1H, 13C NMR, IR, and UV spectra.

ChemInform Abstract: SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-OXO-7-AMINO DERIVATIVES OF 5H-PYRIDO(2,3B)- AND 5H-PYRIMIDO(4,5B)(1,4)THIAZINES

1985 ◽  
Vol 16 (15) ◽  
Author(s):  
N. I. TRAVEN' ◽  
YU. A. ERSHOVA ◽  
A. S. SOKOLOVA ◽  
V. A. CHERNOV ◽  
T. S. SAFONOVA
Keyword(s):  
Antitumor Activity ◽  
Amino Derivatives ◽  
Derivatives Of

Synthesis of amino derivatives of resorcinols by a biogenetically similar scheme

1973 ◽  
Vol 22 (5) ◽  
pp. 1077-1082
Author(s):  
A. A. Akhrem ◽  
A. M. Moiseenkov ◽  
F. A. Lakhvich
Keyword(s):  
Similar Scheme ◽  
Amino Derivatives ◽  
Derivatives Of

Synthesis of 4-Amino Derivatives of 5-Oxoproline

2007 ◽  
Vol 2007 (25) ◽  
pp. 4257-4266 ◽  
Author(s):  
Victor P. Krasnov ◽  
Alexey Yu. Vigorov ◽  
Irina A. Nizova ◽  
Tatyana V. Matveeva ◽  
Alexander N. Grishakov ◽  
...  
Keyword(s):  
Amino Derivatives ◽  
Derivatives Of

Preparation of new amino derivatives of the lactone tanachin and their antimicrobial activity

1996 ◽  
Vol 32 (1) ◽  
pp. 19-22
Author(s):  
M. B. Izbosarov ◽  
B. Kh. Abduazimov ◽  
M. É. Tuichieva ◽  
M. N. Yusupov ◽  
V. M. Malikov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Derivatives ◽  
Derivatives Of

scholarly journals Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.

1989 ◽  
Vol 42 (11) ◽  
pp. 1673-1683 ◽  
Author(s):  
H. A. KIRST ◽  
K. E. WILLARD ◽  
M. DEBONO ◽  
J. E. TOTH ◽  
B. A. TRUEDELL ◽  
...  
Keyword(s):  
Structure Activity ◽  
Amino Derivatives ◽  
Derivatives Of
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