Determination of urinary cadmium excretion as diagnostic procedure to evaluate cadmium exposure of inhabitants of a polluted quarter of stadskanaal

1984 ◽  
Vol 317 (3-4) ◽  
pp. 433-437 ◽  
Author(s):  
G. de Groot ◽  
B. Sangster

Author(s):  
In Soon Song ◽  
Yong Chae Cho ◽  
Soo Young Kim ◽  
Am Park ◽  
Kyung Sun Son ◽  
...  




Author(s):  
Beatriz Valcarcel Salamanca ◽  
Timothy M.D. Ebbels ◽  
Maria De Iorio

AbstractIn this study, we propose a novel statistical framework for detecting progressive changes in molecular traits as response to a pathogenic stimulus. In particular, we propose to employ Bayesian hierarchical models to analyse changes in mean level, variance and correlation of metabolic traits in relation to covariates. To illustrate our approach we investigate changes in urinary metabolic traits in response to cadmium exposure, a toxic environmental pollutant. With the application of the proposed approach, previously unreported variations in the metabolism of urinary metabolites in relation to urinary cadmium were identified. Our analysis highlights the potential effect of urinary cadmium on the variance and correlation of a number of metabolites involved in the metabolism of choline as well as changes in urinary alanine. The results illustrate the potential of the proposed approach to investigate the gradual effect of pathogenic stimulus in molecular traits.





1971 ◽  
Vol 14 (1) ◽  
pp. 172-178 ◽  
Author(s):  
Jay W. Sanders ◽  
Anne Forrest Josey ◽  
Francis J. Kemker

Brief-tone audiometry, the determination of temporal auditory integration of power, has been proposed as a diagnostic procedure on the assumption that the results identify the ear with cochlear pathology. Previous studies have shown a clear distinction between the normal ear and the ear with cochlear impairment but have not included results for the ear with sensory-neural loss from Vlllth nerve lesion. In this study, temporal integration functions were obtained for 10 normal hearers, 10 patients with cochlear pathology and 3 patients with surgically confirmed Vlllth nerve tumors. The cochlear loss patients were clearly distinguished from the normals by abnormality in integration function. Results for the Vlllth nerve tumor patients fell well within the range of normal on the brief-tone test.





2011 ◽  
Vol 10 (1) ◽  
Author(s):  
Valérie Pennemans ◽  
Liesbeth M De Winter ◽  
Elke Munters ◽  
Tim S Nawrot ◽  
Emmy Van Kerkhove ◽  
...  


2018 ◽  
Vol 188 (1) ◽  
pp. 141-150 ◽  
Author(s):  
Leda Chatzi ◽  
Despo Ierodiakonou ◽  
Katerina Margetaki ◽  
Marina Vafeiadi ◽  
Georgia Chalkiadaki ◽  
...  

Abstract Prenatal cadmium exposure has been associated with impaired fetal growth; much less is known about the impact during later childhood on growth and cardiometabolic traits. To elucidate the associations of prenatal cadmium exposure with child growth, adiposity, and cardiometabolic traits in 515 mother-child pairs in the Rhea Mother-Child Study cohort (Heraklion, Greece, 2007–2012), we measured urinary cadmium concentrations during early pregnancy and assessed their associations with repeated weight and height measurements (taken from birth through childhood), waist circumference, skinfold thickness, blood pressure, and serum lipid, leptin, and C-reactive protein levels at age 4 years. Adjusted linear, Poisson, and mixed-effects regression models were used, with interaction terms for child sex and maternal smoking added. Elevated prenatal cadmium levels (third tertile of urinary cadmium concentration (0.571–2.658 μg/L) vs. first (0.058–0.314 μg/L) and second (0.315–0.570 μg/L) tertiles combined) were significantly associated with a slower weight trajectory (per standard deviation score) in all children (β = −0.17, 95% confidence interval (CI): −0.32, −0.02) and a slower height trajectory in girls (β = −0.30, 95% CI: −0.52,−0.09; P for interaction = 0.025) and in children born to mothers who smoked during pregnancy (β = −0.48, 95% CI: −0.83, −1.13; P for interaction = 0.027). We concluded that prenatal cadmium exposure was associated with delayed growth in early childhood. Further research is needed to understand cadmium-related sex differences and the role of coexposure to maternal smoking during early pregnancy.



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