Effects of antipsychotic drugs on the long-term effects of amphetamine on nigro-striatal dopamine neurons in iprindole-treated rats

1984 ◽  
Vol 325 (3) ◽  
pp. 198-204 ◽  
Author(s):  
Larry R. Steranka
Keyword(s):  
Antipsychotic Drugs ◽  
Dopamine Neurons ◽  
Striatal Dopamine ◽  
Long Term Effects

Long-term effects of imipramine on striatal dopamine autoreceptor function: Involvement of both noradrenergic and serotonergic systems

1992 ◽  
Vol 23 (3) ◽  
pp. 397-401 ◽  
Author(s):  
Cristoforo Scavone ◽  
Moacyr Luiz Aizenstein ◽  
Cleopatra da Silva Planeta ◽  
Roberto de Lucia
Keyword(s):  
Striatal Dopamine ◽  
Long Term Effects ◽  
Dopamine Autoreceptor

Dopamine D3 receptor agents as potential new medications for drug addiction

2000 ◽  
Vol 15 (2) ◽  
pp. 140-146 ◽  
Author(s):  
B. Le Foll ◽  
J.C. Schwartz ◽  
P. Sokoloff
Keyword(s):  
Drug Addiction ◽  
Dopamine Neurons ◽  
Receptor Subtypes ◽  
Long Term Effects ◽  
Self Administration ◽  
R And D ◽  
Critical Problems ◽  
Dopamine D3 ◽  
Abused Drugs

SummaryAll drugs abused by humans increase dopamine in the shell of nucleus accumbens, which implicate the neurons of this structure in their hedonic and reinforcing properties. Among the various dopamine receptor subtypes, the D1 (D1R) and D3 (D3R) receptors co-localise in accumbal shell neurons. Synergistic D1R/D3R interactions at this level were found on gene expression and during induction and expression of behavioral sensitisation to levodopa in rats bearing unilateral lesions of dopamine neurons. Behavioral sensitisation to abused drugs is a component of their long-term effects. Converging pharmacologic, human postmortem and genetic studies suggest the involvement of the D3R in reinforcing effects of drugs; D3R agonists reduced cocaine self-administration in rats, without disrupting the maintenance of self-administration. These data suggest the use of D3R agonists as partial substitutes to treat cocaine dependence, by affecting its reward component. However, substitution therapies maintain dependence and may be inefficient on drug craving and relapse, which are the unsolved and critical problems in the treatment of drug addiction. Recently, a highly selective and partial D3R agonist was shown to reduce cocaine-associated cue-controlled behaviour in rats, without having any primary intrinsic effects. As drug-associated cues maintain drug-seeking in animals and elicit craving and relapse in humans, such D3R agents have potential therapeutic applications.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Sign in / Sign up

Export Citation Format

Share Document