Total and free steady-state plasma levels and pharmacokinetics of nifedipine in patients with terminal renal failure

1989 ◽  
Vol 37 (2) ◽  
pp. 185-189 ◽  
Author(s):  
L. v. Bortel ◽  
R. Böhm ◽  
J. Mooij ◽  
P. Schiffers ◽  
K. H. Rahn
Keyword(s):  
Renal Failure ◽  
Steady State ◽  
Plasma Levels ◽  
Terminal Renal Failure ◽  
State Plasma

Steady-state plasma levels of clomipramine and its metabolites: Impact of the sparteine/debrisoquine oxidation polymorphism

1992 ◽  
Vol 43 (4) ◽  
pp. 405-411 ◽  
Author(s):  
K. Kramer Nielsen ◽  
K. Brøsen ◽  
L. F. Gram ◽  
Keyword(s):  
Steady State ◽  
Plasma Levels ◽  
Debrisoquine Oxidation ◽  
Oxidation Polymorphism ◽  
State Plasma

Steady-State Plasma Levels and Pharmacokinetics of Guanfacine in Patients with Renal Insufficiency

Nephron ◽  
1989 ◽  
Vol 53 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Susan H. Carchman ◽  
Domenic A. Sica ◽  
Judith Davis ◽  
James T. Crowe Jr. ◽  
Albert J. Wasserman ◽  
...  
Keyword(s):  
Steady State ◽  
Renal Insufficiency ◽  
Plasma Levels ◽  
State Plasma

Repeated Ingestion of Grapefruit Juice Does Not Alter Clozapine's Steady-State Plasma Levels, Effectiveness, and Tolerability

2001 ◽  
Vol 62 (10) ◽  
pp. 812-817 ◽  
Author(s):  
Hsien-Yuan Lane ◽  
Michael W. Jann ◽  
Yue-Cune Chang ◽  
Chih-Chiang Chiu ◽  
Ming-Chyi Huang ◽  
...  
Keyword(s):  
Steady State ◽  
Plasma Levels ◽  
Grapefruit Juice ◽  
State Plasma

Within-Individual Variation in Steady State Plasma Levels of Different Neuroleptics and Prolactin

1984 ◽  
Vol 144 (6) ◽  
pp. 625-629 ◽  
Author(s):  
R. G. McCreadie ◽  
Margaret Mackie ◽  
David H. Wiles ◽  
Aksel Jorgensen ◽  
Villy Hansen ◽  
...  
Keyword(s):  
Steady State ◽  
Individual Variation ◽  
Plasma Levels ◽  
State Level ◽  
Drug Analysis ◽  
Plasma Prolactin ◽  
Routes Of Administration ◽  
Chronic Schizophrenics ◽  
Before And After ◽  
State Plasma

SummaryEleven male chronic schizophrenics were given, serially, oral pimozide, fluphenazine, and flupenthixol; the two latter were also given intramuscularly as decanoates in oil. Oral haloperidol was given before and after each drug. Analysis of variance of steady state plasma levels of the different neuroleptics showed considerable within-individual variation in such levels, probably due to differences in absorption and metabolism and between routes of administration. The findings suggest that if a patient fails to respond to one neuroleptic, there may be good pharmacokinetic reasons for switching him to another belonging to a different group, or for giving the same neuroleptic by a different route of administration. The study also showed that previous administration of one neurololeptic may influence the steady state level of another. The various neuroleptics produced different effects on plasma prolactin levels.

scholarly journals Pharmacokinetics of Exenatide in nonhuman primates following its administration in the form of sustained-release PT320 and Bydureon

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yazhou Li ◽  
Kelli L. Vaughan ◽  
David Tweedie ◽  
Jin Jung ◽  
Hee Kyung Kim ◽  
...  
Keyword(s):  
Steady State ◽  
Sustained Release ◽  
Plasma Levels ◽  
Nonhuman Primates ◽  
Systemic Exposure ◽  
Pharmacokinetic Profile ◽  
Time Dependent ◽  
Rapid Decline ◽  
Therapeutic Concentration ◽  
State Plasma

AbstractThe time-dependent (30 min - day 84) plasma profile of PT320, a sustained-release (SR)-Exenatide formulation under clinical development for treatment of neurodegenerative disorders, was evaluated in nonhuman primates after a single subcutaneous dose and was compared to Bydureon. Exenatide release from PT320 exhibited a triphasic pharmacokinetic profile. An initial peak occurred at 3 hr post-administration, a secondary peak at 5 days, and achievement of Exenatide steady-state plasma levels from day 10–28. Systemic exposure increased across PT320 doses, and Exenatide levels were maintained above the therapeutic threshold prior to achieving a steady-state. In contrast, Exenatide release from Bydureon exhibited a biphasic profile, with an initial plasma peak at 3 hr, followed by a rapid decline to a sub-therapeutic concentration, and a gradual elevation to provide a steady-state from day 35–49. Exenatide total exposure, evaluated from the area under the time-dependent Exenatide concentration curve, was similar for equivalent doses of PT320 and Bydureon. The former, however, reached and maintained steady-state plasma Exenatide levels more rapidly, without dipping to a sub-therapeutic concentration. Both SR-Exenatide formulations proved well-tolerated and, following a well-regulated initial release burst, generated steady-state plasma levels of Exenatide, but with PT320 producing continuous therapeutic Exenatide levels and more rapidly reaching a steady-state.

Impact of CYP2D6 Polymorphism on Steady-State Plasma Levels of Risperidone and 9-Hydroxyrisperidone in Thai Children and Adolescents with Autism Spectrum Disorder

2017 ◽  
Vol 27 (2) ◽  
pp. 185-191 ◽  
Author(s):  
Natchaya Vanwong ◽  
Nattawat Ngamsamut ◽  
Sadeep Medhasi ◽  
Apichaya Puangpetch ◽  
Montri Chamnanphon ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Steady State ◽  
Children And Adolescents ◽  
Plasma Levels ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Cyp2d6 Polymorphism ◽  
Adolescents With Autism ◽  
State Plasma

P.1.027 A study on the dosage and steady state plasma levels of imipramine in Chinese — preliminary findings

1997 ◽  
Vol 7 ◽  
pp. S143
Author(s):  
H.F.K. Chiu ◽  
Y.K. Wing ◽  
K. Chan
Keyword(s):  
Steady State ◽  
Plasma Levels ◽  
State Plasma

Diurnal Fluctuations in Free and Total Steady-State Plasma Levels of Carbamazepine and Correlation with Intermittent Side Effects

Epilepsia ◽  
1984 ◽  
Vol 25 (4) ◽  
pp. 476-481 ◽  
Author(s):  
Roberto Riva ◽  
Fiorenzo Albani ◽  
Giovanni Ambrosetto ◽  
Manuela Contin ◽  
Pietro Cortelli ◽  
...  
Keyword(s):  
Steady State ◽  
Side Effects ◽  
Plasma Levels ◽  
Diurnal Fluctuations ◽  
State Plasma

Steady-State Plasma Levels of Nortriptyline and Its Hydroxylated Metabolites in Japanese Patients: Impact of CYP2D6 Genotype on the Hydroxylation of Nortriptyline

2000 ◽  
Vol 20 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Sachiyo Morita ◽  
Kazutaka Shimoda ◽  
Toshiyuki Someya ◽  
Yoshitaka Yoshimura ◽  
Kunitoshi Kamijima ◽  
...  
Keyword(s):  
Steady State ◽  
Plasma Levels ◽  
Japanese Patients ◽  
Cyp2d6 Genotype ◽  
Hydroxylated Metabolites ◽  
State Plasma
Sign in / Sign up

Export Citation Format

Share Document