Comparative study of seven neuroendocrine markers in pancreatic endocrine tumours

OBJECTIVE: Evidence exists for the presence of a renin-angiotensin system (RAS) in the pancreas. The aims of this study were to prove the presence of an intrinsic RAS in the human pancreas and to analyse the role of such an RAS in pancreatic endocrine tumours (PETs). METHODS: Gene expression of key RAS components (angiotensinogen and angiotensin II receptors, namely AT1 and AT2) was investigated in human pancreas and in PETs by semi-quantitative RT-PCR and immunohistochemistry. RESULTS: Expression of mRNAs of RAS components was found in human pancreas and in PETs. Data from semi-quantitative RT-PCR analysis demonstrated an increase in the mRNA expression of angiotensinogen and AT2 receptor in PETs when compared with that in normal pancreas. By immunohistochemistry, angiotensinogen protein was predominantly localized in the pancreatic islets while AT1 receptor protein was in the pancreatic ducts. CONCLUSIONS: The data support the notion of the existence of an intrinsic RAS in the human pancreas. It also indicates, for the first time, that such a local pancreatic RAS is subject to regulation by PETs and its significant change may have pathophysiological relevance in patients with PETs.

Download Full-text

The role of lymph node ratio in recurrence after curative surgery for pancreatic endocrine tumours

Pancreatology ◽

10.1016/j.pan.2013.04.285 ◽

2013 ◽

Vol 13 (3) ◽

pp. S81-S82

Author(s):

Claudio Ricci ◽

Giovanni Taffurelli ◽

Marielda D’Ambra ◽

Salvatore Buscemi ◽

Francesco Monari ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Ratio ◽

Curative Surgery ◽

Endocrine Tumours ◽

Node Ratio ◽

Pancreatic Endocrine Tumours

Download Full-text

Etiology, Assessment and Management of WDHA (Watery Diarrhea, Hypokalemia, and Achlorhydria) and VIPoma

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i56b33930 ◽

2021 ◽

pp. 69-75

Author(s):

Mohammed Salah Hussein ◽

RIdha A. Bdulmohsen Al Shaqaqiq ◽

Khaled Mubarak Aldhuaina ◽

Azhar Abdullah Al-qattan ◽

Salwah Mohammed Qaysi ◽

...

Keyword(s):

Islet Cell ◽

Watery Diarrhoea ◽

Watery Diarrhea ◽

Acid Base ◽

Pancreatic Islet Cell ◽

Endocrine Tumours ◽

Pancreatic Endocrine Tumours ◽

Prevalent Symptom ◽

Wdha Syndrome

The syndrome of watery diarrhoea, hypokalemia, and achlorhydria (WDHA syndrome) is an uncommon disorder marked by severe, watery diarrhoea caused by non–beta pancreatic islet cell oversecretion of vasoactive intestinal peptide (VIP). The onset of the disease is gradual, and diagnosis is often months or years later. Long-term dehydration, electrolyte and acid-base abnormalities, and chronic renal failure are all linked to morbidity. Pancreatic endocrine tumours are extremely rare, with less than 10 incidences per million people. VIPomas are uncommon tumours that affect between 0.05 and 2.0 percent of people. The most prevalent symptom is diarrhoea, which affects at least 89 percent of patients. VIPoma is treated with a combination of medicine and surgery The goal of first medical treatment is to reduce symptoms and restore fluids and electrolytes as quickly as possible

Download Full-text