Attempts to use the interference phenomenon to detect mouse leukemia viruses in tissue culture

Despite extensive studies, the correlation between the morphology and pathogenicity of murine leukemia viruses (MLV) has not yet been clarified. The virus particles found in the plasma of leukemic mice belong to 2 distinct groups, 1 or 2% of them being enveloped A particles and the vast majority being of type C. It is generally believed that these 2 types of particles represent different phases in the development of the same virus. Particles of type A have been thought to be an earlier form of type C particles. One of the tissue culture lines established from Friend leukemia solid tumors has provided the material for the present study. The supernatant fluid of the line designated C-1A contains an almost pure population of A particles as illustrated in Figure 1. The ratio is, therefore, the reverse of what is unvariably observed in the plasma of leukemic mice where C particles predominate.

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Genetic evidence for a product of the Fv-1 locus that transfers resistance to mouse leukemia viruses.

Journal of Virology ◽

10.1128/jvi.20.3.589-596.1976 ◽

1976 ◽

Vol 20 (3) ◽

pp. 589-596 ◽

Cited By ~ 6

Author(s):

R W Tennant ◽

B Schluter ◽

F E Myer ◽

J A Otten ◽

W K Yang ◽

...

Keyword(s):

Genetic Evidence ◽

Mouse Leukemia ◽

Leukemia Viruses

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Attempt at Classification of Mouse Leukemia Viruses

Acta Haematologica ◽

10.1159/000209559 ◽

1964 ◽

Vol 32 (2) ◽

pp. 81-88 ◽

Cited By ~ 6

Author(s):

Ludwik Gross

Keyword(s):

Mouse Leukemia ◽

Leukemia Viruses

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Different lymphoid cell targets for transformation by replication-competent moloney and rauscher mouse leukemia viruses

Cell ◽

10.1016/s0092-8674(80)80043-2 ◽

1980 ◽

Vol 19 (3) ◽

pp. 663-669 ◽

Cited By ~ 19

Author(s):

E REDDY ◽

C DUNN ◽

S AARONSON

Keyword(s):

Lymphoid Cell ◽

Mouse Leukemia ◽

Leukemia Viruses

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Long-Term Cultivation in Tissue Culture of Leukemic Cells From Mouse Leukemia Induced by Moloney Virus or by X Rays2

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/27.5.1153 ◽

1961 ◽

Keyword(s):

Tissue Culture ◽

Leukemic Cells ◽

X Rays ◽

Mouse Leukemia

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Mouse Leukemia Viruses

Brenner's Encyclopedia of Genetics ◽

10.1016/b978-0-12-374984-0.00978-5 ◽

2001 ◽

pp. 489-492

Author(s):

H.C. Morse

Keyword(s):

Mouse Leukemia ◽

Leukemia Viruses

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Eine Komplementbindungsreaktion zum Nachweis der bei Leukämieviren verschiedener Säuger vorkommenden gemeinsamen antigenen Komponente

Zeitschrift für Naturforschung B ◽

10.1515/znb-1970-0925 ◽

1970 ◽

Vol 25 (9) ◽

pp. 1029-1036 ◽

Cited By ~ 31

Author(s):

Werner Schäfer ◽

Jens Lange ◽

Liselotte Pister ◽

Eveline Seifert ◽

Fernando de Noronha ◽

...

Keyword(s):

Tissue Culture ◽

Cancer Cells ◽

Human Cancer ◽

Leukemia Virus ◽

Mouse Leukemia ◽

Human Cancer Cells ◽

Mouse Leukemia Virus ◽

Bovine Leukosis

By immunization of a rabbit with purified gs-antigen from mouse leukemia virus (MLV) a potent antiserum (R-gs-serum) was obtained, which reacts specifically with gs-antigen of MLV.In cat leukemia virus (KLV) two types of antigens, probably both group specific, could be demonstrated with anti-KLV-sera by Ouchterlony test. One of these was shown with MLV-sera to be identical with a MLV-gs-antigen component. This antigen occurring in both viruses is called gsinterspecies (interspec.) antigen.R-gs-serum allowed to detect gs-interspec. antigen also by the more sensitive CF-test. [Lispa (leukemia virus interspec. antigen) CF-test]. Preliminary experiments with this test indicated that bovine leukosis as well as human cancer cells can produce an agent in tissue culture which is serologically related to MLV.

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