Comparison of the systemic hemodynamics in normotensive and hypertensive rats

1982 ◽  
Vol 93 (5) ◽  
pp. 584-586
Author(s):  
Sh. I. Ismailov ◽  
O. S. Medvedev
Keyword(s):  
Systemic Hemodynamics ◽  
Hypertensive Rats

Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution

1986 ◽  
Vol 90 (5) ◽  
pp. 1232-1240 ◽  
Author(s):  
D. Kravetz ◽  
E. Sikuler ◽  
R.J. Groszmann
Keyword(s):  
Blood Volume ◽  
Systemic Hemodynamics ◽  
Hypertensive Rats

scholarly journals Effects of calcium antagonists on hepatic and systemic hemodynamics in awake portal hypertensive rats

1996 ◽  
Vol 31 (3) ◽  
pp. 366-372 ◽  
Author(s):  
Masamichi Nagasawa ◽  
Tsunehisa Kawasaki ◽  
Teruya Yoshimi
Keyword(s):  
Calcium Antagonists ◽  
Systemic Hemodynamics ◽  
Hypertensive Rats

Effect of Dopamine β-Hydroxylase Inhibition on Systemic Hemodynamics in Conscious, Spontaneously Hypertensive Rats

Pharmacology ◽  
1990 ◽  
Vol 41 (2) ◽  
pp. 82-90 ◽  
Author(s):  
Miklos Gellai ◽  
Robin E. DeWolf ◽  
Robert R. Ruffolo, Jr.
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Systemic Hemodynamics ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Dopamine Beta Hydroxylase

Effects of verapamil and nifedipine on systemic hemodynamics in spontaneously hypertensive rats

1988 ◽  
Vol 6 (12) ◽  
pp. 1017-1022 ◽  
Author(s):  
Jang Y. Lee ◽  
Alan D. Krueger ◽  
Gerald M. Walsh
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Systemic Hemodynamics ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

An experimental study in reducing blood pressure in spontaneously hypertensive rats through extracellular signal-regulated kinase inhibition

2010 ◽  
Vol 34 (8) ◽  
pp. S31-S31
Author(s):  
Li Jing ◽  
Jian‑zhong Zhang ◽  
Jin‑ping Sun ◽  
Xin An ◽  
Feng‑ying Guo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Experimental Study ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Kinase Inhibition ◽  
Spontaneously Hypertensive ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation

2019 ◽  
Vol 133 (20) ◽  
pp. 2045-2059 ◽  
Author(s):  
Da Zhang ◽  
Xiuli Wang ◽  
Siyao Chen ◽  
Selena Chen ◽  
Wen Yu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Cell ◽  
Pulmonary Artery ◽  
Cell Model ◽  
Site Directed Mutagenesis ◽  
Critical Event ◽  
Hypertensive Rats ◽  
Pulmonary Artery Endothelial Cell

Abstract Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the development of pulmonary arterial hypertension (PAH). However, the pathogenesis of PAEC inflammation remains unclear. Methods: Purified recombinant human inhibitor of κB kinase subunit β (IKKβ) protein, human PAECs and monocrotaline-induced pulmonary hypertensive rats were employed in the study. Site-directed mutagenesis, gene knockdown or overexpression were conducted to manipulate the expression or activity of a target protein. Results: We showed that hydrogen sulfide (H2S) inhibited IKKβ activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole-stimulation or knockdown of cystathionine γ-lyase (CSE), an H2S generating enzyme. Mechanistically, H2S was proved to inhibit IKKβ activity directly via sulfhydrating IKKβ at cysteinyl residue 179 (C179) in purified recombinant IKKβ protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKβ inactivation. Furthermore, to demonstrate the significance of IKKβ sulfhydration by H2S in the development of PAEC inflammation, we mutated C179 to serine (C179S) in IKKβ. In purified IKKβ protein, C179S mutation of IKKβ abolished H2S-induced IKKβ sulfhydration and the subsequent IKKβ inactivation. In human PAECs, C179S mutation of IKKβ blocked H2S-inhibited IKKβ activation and PAEC inflammatory response. In pulmonary hypertensive rats, C179S mutation of IKKβ abolished the inhibitory effect of H2S on IKKβ activation and pulmonary vascular inflammation and remodeling. Conclusion: Collectively, our in vivo and in vitro findings demonstrated, for the first time, that endogenous H2S directly inactivated IKKβ via sulfhydrating IKKβ at Cys179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH.

1638: Erectile Dysfunction and Oxidative Stress-Media Ted Cavernosal Cell Death in Spontaneously Hypertensive Rats

2004 ◽  
Vol 171 (4S) ◽  
pp. 433-433
Author(s):  
Steven Kuntz ◽  
Steven White ◽  
Michael Alba ◽  
Mahadevan Rajasekaran
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Erectile Dysfunction ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
And Oxidative Stress

777 Exposure of spontaneous hypertensive rats to ambient particulate matter affects cardiovascular performance in a Langendorff model

2003 ◽  
Vol 2 (1) ◽  
pp. 168-169
Author(s):  
J MEIRING ◽  
K BAGATE ◽  
M GERLOFSNIJLAND ◽  
F CASSEE ◽  
P BORM
Keyword(s):  
Particulate Matter ◽  
Ambient Particulate Matter ◽  
Hypertensive Rats ◽  
Cardiovascular Performance
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