Protective action of phenazepam and sodium hydroxybutyrate on somatic manifestations of immobilization stress

1983 ◽  
Vol 96 (6) ◽  
pp. 1723-1726 ◽  
Author(s):  
L. A. Malikova ◽  
V. A. Arefolov
Keyword(s):  
Immobilization Stress ◽  
Protective Action ◽  
Sodium Hydroxybutyrate

scholarly journals The influence of oligopeptides - the homologues of ACTH15-18 on the liver and adrenal glands in the rats on the model of acute immobilization stress

2017 ◽  
Vol 15 (4) ◽  
pp. 30-37
Author(s):  
Olesya V Kudina ◽  
Sergey Yu Shtrygol’ ◽  
Aleksandr A Kolobov ◽  
Yulia B Lar’yanovska
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Adrenal Glands ◽  
Immobilization Stress ◽  
Protective Action ◽  
Antioxidant Effect ◽  
Histological Structure ◽  
Reference Drug ◽  
Depth Study ◽  
Increased Activity ◽  
Positive Effect

An in-depth study the possible links of the stress-protective action of oligopeptides - homologues of the of adrenocorticotropic hormone fragment (15-18) on the model of acute immobilization stress has been carried out. A marked antioxidant effect, not inferior to the reference medicine “Semax”, has been detected in the blood serum and liver of the rats. The results of the morphological study of liver tissue also indicate the normalization of the stress-induced damage in the organ under the influence of oligopeptides (KK-1, KK-5). Both peptides have been exceeded the reference drug, however, the peptide KK-1 had the marked positive effect on the reduction of histological structure of the liver. The stress-protective action of the investigated oligopeptides KK-1 and KK-5 is confirmed by their ability to reduce the increased activity of steroidogenesis and reduce the release of catecholamines, as well as normalize the damaged structure of the adrenal cortex. According to the indices of the adrenal structure recovering, the peptide KK-1 exceeded the reference drug and the peptide KK-1. (For citation: Kudina OV, Shtrygol’ SYu, Kolobov AA, Larjanovskaja YuB, et al. The influence of oligopeptides - the homologues of ACTH15-18 on the liver and adrenal glands in the rats on the model of acute immobilization stress. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):30-37. doi: 10.17816/RCF15430-37).

State of peripheral catecholaminergic systems during pharmacologic correction of immobilization stress by sodium hydroxybutyrate

1985 ◽  
Vol 100 (3) ◽  
pp. 1222-1224
Author(s):  
E. B. Khaisman ◽  
L. A. Malikova ◽  
V. A. Arefolov
Keyword(s):  
Immobilization Stress ◽  
Sodium Hydroxybutyrate ◽  
Pharmacologic Correction

Chronic immobilization stress induces anxiety-related behaviors and affects brain essential minerals in male rats

2020 ◽  
pp. 1-8
Author(s):  
Zafer Sahin ◽  
Alpaslan Ozkurkculer ◽  
Omer Faruk Kalkan ◽  
Ahmet Ozkaya ◽  
Aynur Koc ◽  
...  
Keyword(s):  
Immobilization Stress ◽  
Central Area ◽  
Essential Elements ◽  
Male Rats ◽  
Control Group ◽  
Male Wistar Rats ◽  
Swimming Test ◽  
The Brain ◽  
Center Area ◽  
Chronic Immobilization Stress

Abstract. Alterations of essential elements in the brain are associated with the pathophysiology of many neuropsychiatric disorders. It is known that chronic/overwhelming stress may cause some anxiety and/or depression. We aimed to investigate the effects of two different chronic immobilization stress protocols on anxiety-related behaviors and brain minerals. Adult male Wistar rats were divided into 3 groups as follows ( n = 10/group): control, immobilization stress-1 (45 minutes daily for 7-day) and immobilization stress-2 (45 minutes twice a day for 7-day). Stress-related behaviors were evaluated by open field test and forced swimming test. In the immobilization stress-1 and immobilization stress-2 groups, percentage of time spent in the central area (6.38 ± 0.41% and 6.28 ± 1.03% respectively, p < 0.05) and rearing frequency (2.75 ± 0.41 and 3.85 ± 0.46, p < 0.01 and p < 0.05, respectively) were lower, latency to center area (49.11 ± 5.87 s and 44.92 ± 8.04 s, p < 0.01 and p < 0.01, respectively), were higher than the control group (8.65 ± 0.49%, 5.37 ± 0.44 and 15.3 ± 3.32 s, respectively). In the immobilization stress-1 group, zinc (12.65 ± 0.1 ppm, p < 0.001), magnesium (170.4 ± 1.7 ppm, p < 0.005) and phosphate (2.76 ± 0.1 ppm, p < 0.05) levels were lower than the control group (13.87 ± 0.16 ppm, 179.31 ± 1.87 ppm and 3.11 ± 0.06 ppm, respectively). In the immobilization stress-2 group, magnesium (171.56 ± 1.87 ppm, p < 0.05), phosphate (2.44 ± 0.07 ppm, p < 0.001) levels were lower, and manganese (373.68 ± 5.76 ppb, p < 0.001) and copper (2.79 ± 0.15 ppm, p < 0.05) levels were higher than the control group (179.31 ± 1.87 ppm, 3.11 ± 0.06 ppm, 327.25 ± 8.35 ppb and 2.45 ± 0.05 ppm, respectively). Our results indicated that 7-day chronic immobilization stress increased anxiety-related behaviors in both stress groups. Zinc, magnesium, phosphate, copper and manganese levels were affected in the brain.

Effects of immobilization stress on memory and neuronal plasticity in the cortical divisions of rats

2012 ◽  
Author(s):  
D. S. Vasilev ◽  
N. M. Dubrovskaya ◽  
N. L. Tumanova ◽  
I. A. Zhuravin
Keyword(s):  
Neuronal Plasticity ◽  
Immobilization Stress

Identifying Present Danger; Taking Protective Action

2010 ◽  
Author(s):  
Travis Erickson
Keyword(s):  
Protective Action

Liquorice exaggerates protective action of Solanum xanthocarpum against cigarette smoke induced pulmonary inflammation

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
RA Manek ◽  
NR Sheth ◽  
JR Chavda ◽  
JD Vaghasiya ◽  
KP Modi ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Protective Action ◽  
Pulmonary Inflammation ◽  
Solanum Xanthocarpum

Action of Lysolecithin on Blood Platelets

1963 ◽  
Vol 09 (03) ◽  
pp. 512-524 ◽  
Author(s):  
Chava Kirschmann ◽  
Sara Aloof ◽  
Andre de Vries
Keyword(s):  
Blood Platelets ◽  
Protective Action ◽  
Platelet Surface ◽  
Washed Platelet ◽  
Sufficient Concentration ◽  
Saline Medium

SummaryLysolecithin is adsorbed to washed blood platelets and, at sufficient concentration, lyses them, inhibits their clot-retracting activity and promotes their thromboplastin-generating activity. Lysolecithin adsorption to the platelet was studied by using P32-labelled lysolecithin obtained from the liver of rats injected with labelled orthophosphate. The amount of lysolecithin adsorbed to the surface of the washed platelet in saline medium is dependent on the concentration of lysolecithin in solution and reaches saturation — 5 × 10-8 jig per platelet — at a concentration of 9—10 µg per ml. Platelet lysis in saline medium begins at a lysolecithin concentration higher than 18 jig per ml. Plasma and albumin prevent adsorption of lysolecithin to the platelet and protect the platelet from damage by lysolecithin. Albumin is able to remove previously adsorbed lysolecithin from the platelet surface. The protective action of plasma explains the lack of platelet damage in blood, the plasma lecithin of which has been converted to lysolecithin by the action of Vipera palestinae venom phosphatidase, in vitro and in vivo.

The effect of acute immobilization stress on the expression of synaptic proteins in serotonin transporter deficient mice

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
SL Nietzer ◽  
AG Schmitt ◽  
G Ortega ◽  
C Kriegebaum ◽  
L Gutknecht ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Immobilization Stress ◽  
Synaptic Proteins ◽  
Deficient Mice

EFFECT OF STRESS ON THE PROFILE OF PLASMA STEROIDS IN BABOONS (PAPIO HAMADRYAS)

1979 ◽  
Vol 90 (2) ◽  
pp. 372-384 ◽  
Author(s):  
N. P. Goncharov ◽  
A. G. Taranov ◽  
A. V. Antonichev ◽  
V. M. Gorlushkin ◽  
T. Aso ◽  
...  
Keyword(s):  
Luteal Phase ◽  
Immobilization Stress ◽  
Marked Decrease ◽  
Follicular Phase ◽  
Papio Hamadryas ◽  
Pronounced Increase ◽  
Consistent Finding ◽  
Plasma Steroids ◽  
Competitive Protein Binding ◽  
17 Hydroxyprogesterone

ABSTRACT Adult baboons (5 males and 5 females) were exposed to immobilization stress by being strapped to a table in a horizontal position for 2 h. In females the experiment was performed during both the follicular and luteal phase. Peripheral blood was withdrawn at frequent intervals, the first sample just before immobilization, and the last one 3 days later. A number of steroids were measured in blood plasma samples by radioimmunoassay (17-hydroxypregnenolone, 17-hydroxyprogesterone, pregnenolone, testosterone, dihydrotestosterone, progesterone, 20α-dihydroprogesterone, oestrone, oestradiol) or competitive protein binding (cortisol) techniques. The cortisol levels exhibited a marked increase in both sexes. This increase was observed already during the immobilization and lasted for approximately 24 h. A similar, even more pronounced increase was seen in 17-hydroxypregnenolone, 17-hydroxyprogesterone and pregnenolone levels. A marked, long-lasting (72 h) decrease of testosterone and dihydrotestosterone levels was a consistent finding in male baboons. This was not observed in the females which, on the other hand, exhibited a marked decrease (duration 48 h) of progesterone and 20α-dihydroprogesterone levels during the luteal phase, and a significant decrease (duration > 24 h) of oestradiol and oestrone concentrations during the follicular phase. It is concluded that stress has a marked inhibitory action on gonadal function both in male and female baboons. In females the inhibition of steroidogenetic function is exerted both on the ovarian follicles and on the corpus luteum.

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