Effect of delta-sleep peptide on epileptic activity during metrazol kindling

1988 ◽  
Vol 106 (3) ◽  
pp. 1220-1224
Author(s):  
A. A. Shandra ◽  
L. S. Godlevskii ◽  
G. N. Kryzhanovskii ◽  
R. F. Makul'kin ◽  
I. I. Mikhaleva ◽  
...  
Keyword(s):  
Epileptic Activity ◽  
Delta Sleep ◽  
Metrazol Kindling

The hippocampus as a determinant structure generating epileptic activity during metrazol kindling

1985 ◽  
Vol 99 (5) ◽  
pp. 547-552 ◽  
Author(s):  
G. N. Kryzhanovskii ◽  
A. A. Shandra ◽  
R. F. Makul'kin ◽  
L. S. Godlevskii
Keyword(s):  
Epileptic Activity ◽  
Determinant Structure ◽  
Metrazol Kindling

Effect of brain extracts from rats subjected to metrazol kindling on generalized epileptic activity

1989 ◽  
Vol 107 (3) ◽  
pp. 291-294
Author(s):  
G. N. Kryzhanovskii ◽  
M. Yu. Karganov ◽  
A. A. Shandra ◽  
L. S. Godlevskii ◽  
V. K. Lutsenko ◽  
...  
Keyword(s):  
Epileptic Activity ◽  
Brain Extracts ◽  
Generalized Epileptic Activity ◽  
Metrazol Kindling

Effect of destruction of the hippocampus and caudate nucleus on development of epileptic activity associated with metrazol kindling

1985 ◽  
Vol 100 (4) ◽  
pp. 1326-1329 ◽  
Author(s):  
G. N. Kryzhanovskii ◽  
A. A. Shandra ◽  
R. F. Makul'kin ◽  
L. S. Godlevskii ◽  
I. N. Moiseev
Keyword(s):  
Caudate Nucleus ◽  
Epileptic Activity ◽  
Metrazol Kindling

Effect of delta sleep peptide in cortical epileptic activity in rats and cats

1987 ◽  
Vol 104 (5) ◽  
pp. 1568-1571
Author(s):  
G. N. Kryzhanovskii ◽  
A. A. Shandra ◽  
L. S. Godlevskii ◽  
M. N. Karpova ◽  
I. I. Mikhaleva ◽  
...  
Keyword(s):  
Epileptic Activity ◽  
Delta Sleep

STUDY OF THE COMBINED INFLUENCE OF SODIUM THIOPENTAL AND DELTA SLEEP-INDUCING PEPTIDE ON ANTIOXIDANT DEFENSE SYSTEM IN RATS

2016 ◽  
pp. 49-52
Author(s):  
A. V. Shvetsov ◽  
E. G. Batotsyrenova ◽  
N. A. Dyuzhikova ◽  
V. A. Kashuro ◽  
N. V. Lapina ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Time Interval ◽  
Sodium Thiopental ◽  
Antioxidant Defense Enzymes ◽  
Delta Sleep ◽  
Thiopental Coma ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Delta Sleep Inducing Peptide

A biochemical investigation was performed into activity of rat antioxidant defense enzymes at different time interval after administration of sodium thiopental and delta-sleep-inducing peptide (DSIP). It was shown that thiopental coma was accompanied by a decreased level of superoxide dismutase ( 6 and 24 h after exposure) and increased level of caspase-3 ( 6 h after exposure) in the rat blood plasma. A pharmacological correction with DSIP induced a decrease of the level of superoxide dismutase ( 6 and 24 h after exposure), glutathione peroxidase and glucose 6-phosphate dehydrogenase (after 6h).

Epileptogenicity and Epileptic Activity: Mechanisms in an Invertebrate Model Nervous System

2004 ◽  
Vol 5 (5) ◽  
pp. 473-484 ◽  
Author(s):  
U. Altrup
Keyword(s):  
Nervous System ◽  
Epileptic Activity ◽  
Invertebrate Model

scholarly journals Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug

Drug Research ◽  
2020 ◽  
Author(s):  
Meenakshi Dhanawat ◽  
Sumeet Gupta ◽  
Dinesh Kumar Mehta ◽  
Rina Das
Keyword(s):  
Epileptic Activity ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Nipecotic Acid ◽  
Design Synthesis ◽  
Hydrophilic Nature ◽  
Carrier Mediated Transport ◽  
Ester Prodrug ◽  
Hplc Data

Nipecotic acid is considered to be one of the most potent inhibitors of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Due to its hydrophilic nature, nipecotic acid does not readily cross the blood-brain barrier (BBB). Large neutral amino acids (LAT1)-knotted nipecotic acid prodrug was designed and synthesized with the aim to enhance the BBB permeation by the use of carrier-mediated transport. The synthesized prodrug was tested in animal models of Pentylenetetrazole (PTZ)-induced convulsions in mice. Further pain studies were carried out followed by neurotoxicity estimation by writhing and rota-rod test respectively. HPLC data suggests that the synthesized prodrug has improved penetration through BBB. Nipecotic acid-L-serine ester prodrug with considerable anti-epileptic activity, and the ability to permeate the BBB has been successfully synthesized. Graphical Abstract.

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