In vitro anti-acetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes: Correlations with thymic histology and thymic epithelial-cell interactions

1987 ◽  
Vol 7 (3) ◽  
pp. 225-234 ◽  
Author(s):  
D. Safar ◽  
S. Berrih-Aknin ◽  
E. Morel
Keyword(s):  
Epithelial Cell ◽  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Cell Interactions ◽  
Thymic Epithelial Cell ◽  
Antibody Synthesis ◽  
Receptor Antibody ◽  
Acetylcholine Receptor Antibody ◽  
Anti Acetylcholine

IN-VITRO SYNTHESIS OF ANTI-ACETYLCHOLINE-RECEPTOR ANTIBODY BY THYMIC LYMPHOCYTES IN MYASTHENIA GRAVIS

The Lancet ◽  
1978 ◽  
Vol 311 (8059) ◽  
pp. 305-307 ◽  
Author(s):  
Angela Vincent ◽  
H.C. Thomas ◽  
GlenisK. Scadding ◽  
J. Newsom-Davis
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
In Vitro Synthesis ◽  
Receptor Antibody ◽  
Acetylcholine Receptor Antibody ◽  
Anti Acetylcholine

scholarly journals The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Jung Jin Lee ◽  
Kyung Min Koh ◽  
Ungsoo Samuel Kim
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptor ◽  
Antibody Test ◽  
Thyroid Autoantibodies ◽  
Thyroid Autoantibody ◽  
Receptor Antibody ◽  
Ocular Myasthenia ◽  
Acetylcholine Receptor Antibody ◽  
Ocular Myasthenia Gravis ◽  
Anti Acetylcholine

Aim. To estimate the clinical significance of anti-acetylcholine receptor antibody (anti-AChR-Ab) levels in suspected ocular myasthenia gravis.Methods. In total, 144 patients complaining of fluctuating diplopia and ptosis were evaluated for serum levels of anti-acetylcholine receptor antibody and their medical charts were retrospectively reviewed. Subjects were classified into three groups: variable diplopia only, ptosis only, and both variable diplopia and ptosis. We investigated serum anti-AChR-Ab titer levels and performed thyroid autoantibody tests.Results. Patients’ chief complaints were diplopia (N=103), ptosis (N=12), and their concurrence (N=29). Abnormal anti-AChR-Ab was observed in 21 of 144 patients (14.1%). Between the three groups, mean age, number of seropositive patients, and mean anti-AChR-Ab level were not significantly different (P=0.224, 0.073, and 0.062, resp.). Overall, 27.5% of patients had abnormal thyroid autoantibodies.Conclusion. The sensitivity of anti-AChR-Ab was 14.1% in suspected ocular myasthenia gravis and seropositivity in myasthenia gravis patients showed a high correlation with the presence of thyroid autoantibodies.

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