Promoting action of croton oil on gastrocarcinogenesis by N-methyl-N?-nitro-N-nitrosoguanidine in rats

1979 ◽  
Vol 93 (3) ◽  
pp. 323-327 ◽  
Author(s):  
N. Matsukura ◽  
T. Kawachi ◽  
T. Sano ◽  
K. Sasajima ◽  
T. Sugimura
Keyword(s):  
Croton Oil

scholarly journals The Phenol–Croton Oil Peel Was Originally Investigated in the 1980s

2009 ◽  
Vol 29 (5) ◽  
pp. 446-446
Author(s):  
David L. Larson ◽  
George J. Korkos
Keyword(s):  
Croton Oil

Investigation of Analgesic, Anti-Inflammatory, Hypoglycaemic, Neuropharmacological and Cytotoxic Properties of Clerodendrum viscosum (Leaves)

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tanny SZ ◽  
◽  
Ropuk RS ◽  
Patowary AA ◽  
Lata L ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Glucose Tolerance ◽  
Brine Shrimp ◽  
Depressant Effect ◽  
Sleeping Time ◽  
Ear Edema ◽  
Cns Depressant ◽  
Croton Oil ◽  
Anti Inflammatory ◽  
Clerodendrum Viscosum

Clerodendrum viscosum (CV) has been used traditionally to treat medical problems like asthma, ulcer, inflammation, pyrexia, diabetes, malaria, skin diseases, snakebite and tumor by folk practitioners. The present study evaluated the analgesic, antiinflammatory, neuropharmacological and cytotoxic properties C. viscosum (leaves) in rodents. Swiss albino mice of either sex weighing 25-30 gm and SD rats (150-180 mg) were divided into control (DW), standard (model specific) as well as test groups (n=6). Analgesic potential was evaluated using acetic acid-induced writhing and formalin induced pawlicking test. Anti-inflammatory properties were evaluated by xylene and croton oil induced ear edema test. Glucose tolerance was evaluated by OGTT in normal rats. Pentobarbital induced sleeping time test was applied to assess neuropharmacological activity. Also, Brine shrimp lethality bioassay method was employed for cytotoxicity evaluation. The alcoholic extracts showed significant antinociceptive activity in acetic acid test (p<0.01) and formalin test (p<0.05) at the dose of 1000mg/kg bw. The crude extract reduced inflammation significantly (p<0.01) in both xylene and croton oil induced ear edema test. At the dose of 1000mg/kg it increased glucose tolerance significantly (p<0.05) in normal rats. CV extract significantly (p<0.01) increased sleeping time indicating CNS depressant effect. The extract exhibited a potent cytotoxicity against brine shrimp (LC50=316.23μg/ml). C. viscosum leaves showed analgesic, antiinflammatory, hypoglycemic and CNS depressant effect against experimentally induced model mice. It also possessed cytotoxic properties and further studies are required to evaluate these effects and the potential of the plant.

scholarly journals CROTON OIL IN CHOLERA.

The Lancet ◽  
1832 ◽  
Vol 19 (479) ◽  
pp. 181-182
Author(s):  
Patrick Gillespie
Keyword(s):  
Croton Oil

scholarly journals Gratophyllum Pictum (L.) Griff Extract as Anti-Inflammatory on Wistar Rat with Experimental Hemorrhoids. Study on serum IL-6, COX-2, TNF-alpha and total leucocytes in anal tissue.

2020 ◽  
Author(s):  
Sigit Adi Prasetyo ◽  
Ignatius Riwanto ◽  
Edi Dharmana ◽  
Neni Susilaningsih ◽  
Yan Wisnu Prajoko ◽  
...  
Keyword(s):  
Leucocyte Count ◽  
Wistar Rat ◽  
Tnf Alpha ◽  
Croton Oil ◽  
Post Test ◽  
Physiologic Saline ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Anti Inflammation ◽  
Better Than

The author would like to study the effects of ethanol Graptophyllum pictum (L.) Griff extract (EGPE) as anti-inflammation on wistar with experimental hemorrhoids. RCT post-test only design were done on 28 wistar, that were allocated into four groups. The 2nd , 3rd and 4th group were induced with 6% croton oil into anus for three days, the 1st group was not induced. On the 4th day, 1st and 2nd group were given physiologic saline, 3rd and 4th group was given EGPE 100 mg and 300 mg/ kg bw respectively. At the 9th day, before termination, blood was aspirated from retro-ocular region for examination of serum IL-6, COX-2 and TNF-alpha using ELISA method, and SGOT, SGPT, urea and creatinine level. Anus was removed and prepared for microscopic examination to count the leucocyte under 400 HPF. Induction of 6% croton oil was significantly increased TNF-alpha, IL-6, COX-2 and leucocyte count. Treatment with EGPE dose 100 mg and 300 mg/ kg bw significantly reduce TNF-alpha, IL-6, COX-2 and leucocyte count, dose 100 mg was even better than 300 mg except for leucocyte count. SGOT, SGPT, blood urea and creatinine were not significantly different among groups. In conclusion, the EGPE 100 mg and 300 mg have anti-inflammatory effects in hemorrhoids wistar, which can suppress IL-6, COX-2, TNF-alpha, and total leucocytes. The EGPE dose 100 mg is better than dose 300 mg. EGPE save for kidney and liver.

scholarly journals Effect of Rubus suavissimus extract on croton oil induction murine ear inflammation model.

Ensho ◽  
1994 ◽  
Vol 14 (4) ◽  
pp. 323-327
Author(s):  
Zhi-bo Yang ◽  
Yoshiyuki Ishikura ◽  
Kouich Hirai ◽  
Wataru Hujii ◽  
Yoshihide Suwa ◽  
...  
Keyword(s):  
Inflammation Model ◽  
Croton Oil

scholarly journals Croton Oil

2020 ◽  
Author(s):  
Keyword(s):  
Croton Oil
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