High-affinity [3H]inositol uptake by dissociated brain cells and cultured fibroblasts from fetal mice

1991 ◽  
Vol 16 (8) ◽  
pp. 913-918 ◽  
Author(s):  
B. R. Fruen ◽  
B. R. Lester

Life Sciences ◽  
1996 ◽  
Vol 59 (5-6) ◽  
pp. 435-449 ◽  
Author(s):  
Henrike Hartmann ◽  
Anne Eckert ◽  
Karsten Velbinger ◽  
Michael Rewsin ◽  
Walter E. Müller


1981 ◽  
Vol 6 (5) ◽  
pp. 659-683 ◽  
Author(s):  
L. L. Sarliéve ◽  
J. P. Delaunoy ◽  
A. Dierich ◽  
A. Ebel ◽  
M. Fabre ◽  
...  




1979 ◽  
Vol 46 (1-2) ◽  
pp. 117-121 ◽  
Author(s):  
Z. Janka ◽  
I. Szentistv�nyi ◽  
F. Joo ◽  
A. Juh�sz ◽  
�. Riman�czy


1980 ◽  
Vol 36 (9) ◽  
pp. 1071-1072 ◽  
Author(s):  
Z. Janka ◽  
I. Szentistványi ◽  
A. Juhász ◽  
A. Rimanóczy


1980 ◽  
Vol 189 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Louis L. Sarlieve ◽  
G. Subba Rao ◽  
Graham LeM. Campbell ◽  
Ronald A. Pieringer




1990 ◽  
Vol 270 (1) ◽  
pp. 119-123 ◽  
Author(s):  
B R Fruen ◽  
B R Lester

The inositol metabolism of Down's syndrome (DS, trisomy 21) skin fibroblasts was examined. We report that DS cells accumulated [3H]inositol 2-3-fold faster than did other aneuploid or diploid controls. In contrast, trisomy 21 did not affect the uptake of choline, serine or glucose. Kinetic analysis demonstrated an increased maximal velocity of high-affinity, Na(+)-dependent, inositol transport, consistent with the expression of higher numbers of transporters by DS cells. Enhanced uptake was accompanied by a proportional increase in the incorporation of radiolabelled inositol into phospholipid. We suggest that an imbalance of inositol metabolism may contribute to plasma membrane abnormalities characteristic of DS cells.





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