Higher protective activity of Fab' fragment compared to F(ab')2 and IgG on experimental tetanus

1988 ◽  
Vol 4 (3) ◽  
pp. 339-348
Author(s):  
Celid�ia A. C. Vaz ◽  
H. Ferreira ◽  
Vera L. G. Calich
Keyword(s):  
Protective Activity ◽  
Fab Fragment ◽  
Experimental Tetanus

Decisive Diagnosis of Infected Mandibular Osteoradionecrosis with a Tc-99m-labelled Anti-granulocyte Fab′-fragment

1999 ◽  
Vol 38 (07) ◽  
pp. 309-311 ◽  
Author(s):  
W. Brenner ◽  
H. Terheyden ◽  
K. H. Bohuslavizki ◽  
E. Henze ◽  
W. U. Kampen
Keyword(s):  
Blood Pool ◽  
Bone Scanning ◽  
Acute Osteomyelitis ◽  
Elevated Blood ◽  
Fab Fragment ◽  
Postoperative Changes ◽  
Three Phase ◽  
Golden Standard ◽  
Blood Pool Activity ◽  
Bone Inflammation

SummaryThe accepted golden standard for detection of inflammatory bone disease is conventional three-phase bone scanning. Hyperperfusion, a high blood-pool activity and elevated bone metabolism are typical signs for an acute osteomyelitis. However, in case of subacute, chronic inflammation, neither elevated blood flow nor high blood-pool activity may be seen. This may cause difficulties in differentiating such cases from neoplastic or postoperative changes. This case report verifies the possible advantage of immunoscintigraphy with Tc-99m-labelled antigranulocyte Fab′-fragments (LeukoScan®) in a patient with infected mandibular osteoradionecrosis, who had equivocal clinical symptomes and questionable radiographic results. LeukoScan® is shown to be more sensitive in case of subacute bone inflammation compared with three-phase bone scanning. However, acquisition of delayed images after 24 hours including SPECT is inevitable in case of negative scans during the first hours of investigation.

Anti-thrombotic Effect of a PAI-1 Inhibitor in Rats Given Endotoxin

1996 ◽  
Vol 75 (01) ◽  
pp. 118-126 ◽  
Author(s):  
T Abrahamsson ◽  
V Nerme ◽  
M Strömqvist ◽  
B Åkerblom ◽  
A Legnehed ◽  
...  
Keyword(s):  
Plasminogen Activator Inhibitor ◽  
Rat Plasma ◽  
Clot Lysis ◽  
Fibrin Deposition ◽  
Plasminogen Activator Inhibitor 1 ◽  
Fab Fragment ◽  
Dose Dependent Decrease ◽  
Pai 1

SummaryThe aim of this study was to investigate the anti-thrombotic effects of an inhibitor of the plasminogen activator inhibitor-1 (PAI-1) in rats given endotoxin. In studies in vitro, PRAP-1, a Fab-fragment of a polyclonal antibody against human PAI-1, was shown to inhibit PAI-1 activity in rat plasma as well as to stimulate clot-lysis of the euglobulin fraction derived from rat plasma. Endotoxin administered to anaesthetised rats produced a marked increase in plasma PAI-1 activity. To study fibrin formation and lysis in vivo after intravenous (i. v.) injection of the coagulant enzyme batroxobin, 125I-fibrinogen was administered to the animals. The thrombi formed by batroxobin were rapidly lysed in control animals, while the rate of lysis was markedly attenuated in rats given endotoxin. PRAP-1 was administered i.v. (bolus + infusion) to rats given endotoxin and batroxobin and the PAI-1 inhibitor caused a dose-dependent decrease in the 125I-fibrin deposition in the lungs. An immunohistochemical technique was used to confirm this decrease in density of fibrin clots in the tissue. Furthermore, PRAP-1 decreased plasma PAI-1 activity in the rats and this reduction was correlated to the decrease in lung 125I-fibrin deposition at the corresponding time point. It is concluded that in this experimental model the PAI-1 antibody PRAP-1 may indeed inhibit thrombosis in animals exposed to endotoxin.

Nutrition as an important component of treatment and rehabilitation in cancer patients

2020 ◽  
pp. 15-22
Author(s):  
T.F. Tatarchuk ◽  
◽  
E.G. Manzhalii ◽  
D.V. Pominchuk ◽  
T.S. Shevchuk ◽  
...  
Keyword(s):  
Cancer Patients ◽  
High Frequency ◽  
Nutritional Support ◽  
Digestive System ◽  
Multidisciplinary Approach ◽  
Dietary Factors ◽  
Protective Activity ◽  
Macro And Micronutrients ◽  
Diet And Lifestyle ◽  
Cachexia Syndrome

The article deals with the importance of nutritional support for cancer patients. The high frequency of malnutrition and impaired absorption of macro and micronutrients in cancer patients and, which, at its maximum, is anorexia-cachexia syndrome, is the direct cause of the patient’s death. The progression of the tumor process is always accompanied by a violation of nutritional status, which is manifested in changes in weight, weakness, decreased physical activity, and disorders of the digestive system. It is estimated that about half of cancer-related deaths can be prevented, many of which are due to diet and lifestyle. Dietary factors can be involved in the initiation of tumor growth (carcinogens), promote growth, or have protective activity against the development of cancer. Therefore, nutritional support is one of the important components of a multidisciplinary approach in the treatment of cancer. Based on the analysis of the literature, the main tasks of nutritional support, indications, methods and criteria for the effectiveness of therapeutic nutrition are determined for the practitioner, a brief overview of the diets that are used by cancer patients is presented, and a list of anticarcinogenic products is compiled. Key words: anticarcinogenic products, diet, nutritional support, cancer patient, cancer prevention, nutrition.

Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity

2019 ◽  
Vol 38 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Miao Chen ◽  
Vijaya Paul Samuel ◽  
Yi Wu ◽  
Minyan Dang ◽  
Yukiat Lin ◽  
...  
Keyword(s):  
Cardiac Toxicity ◽  
Protective Activity

Protective Activity of Fucoidan and Alginic Acid against Free Radical-Induced Oxidative Stress under in Vitro and Cellular System

2007 ◽  
Vol 12 (4) ◽  
pp. 191-196 ◽  
Author(s):  
Mi-Jung So ◽  
Boh-Kyung Kim ◽  
Mi-Jin Choi ◽  
Kun-Young Park ◽  
Sook-Hee Rhee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Alginic Acid ◽  
Cellular System ◽  
Protective Activity

Protective Activity of Seolitae Chungkukjang Added with Green Tea against Cellular Oxidative Stress induced by AAPH

2009 ◽  
Vol 14 (1) ◽  
pp. 37-42
Author(s):  
Hyun-Young Park ◽  
Hee-Seob Lee ◽  
Eun-Ju Cho
Keyword(s):  
Oxidative Stress ◽  
Green Tea ◽  
Protective Activity

Synthesis, Genotoxicity and UV-protective Activity of New Benzofuroxans Substituted by Aromatic Amines

2012 ◽  
Vol 10 (2) ◽  
pp. 145-154 ◽  
Author(s):  
Elena Alexandrovna Chugunova ◽  
Marina Alexandrovna Sazykina ◽  
Elmira Mingaleevna Gibadullina ◽  
Alexander Romanovich Burilov ◽  
Ivan Sergeevich Sazykin ◽  
...  
Keyword(s):  
Aromatic Amines ◽  
Protective Activity

Ultra scale-down approach for the prediction of full-scale recovery of ovine polycolonal immunoglobulins used in the manufacture of snake venom-specific Fab fragment

2002 ◽  
Vol 81 (2) ◽  
pp. 149-157 ◽  
Author(s):  
G. Neal ◽  
J. Christie ◽  
E. Keshavarz-Moore ◽  
P. Ayazi Shamlou
Keyword(s):  
Snake Venom ◽  
Full Scale ◽  
Fab Fragment ◽  
Scale Down
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