Ultra scale-down approach for the prediction of full-scale recovery of ovine polycolonal immunoglobulins used in the manufacture of snake venom-specific Fab fragment

2002 ◽  
Vol 81 (2) ◽  
pp. 149-157 ◽  
Author(s):  
G. Neal ◽  
J. Christie ◽  
E. Keshavarz-Moore ◽  
P. Ayazi Shamlou
2016 ◽  
Vol 181 ◽  
pp. 832-837 ◽  
Author(s):  
Takashi Onodera ◽  
Daisuke Takayama ◽  
Akiyoshi Ohashi ◽  
Takashi Yamaguchi ◽  
Shigeki Uemura ◽  
...  

Author(s):  
Takashi Onodera ◽  
Tsutomu Okubo ◽  
Daisuke Takayama ◽  
Kazuaki Syutsubo ◽  
Takashi Yamaguchi ◽  
...  

Abstract The effect of shock-loading on the performance of a full-scale down-flow hanging sponge (DHS), used to treat effluent from an up-flow anaerobic sludge blanket treating municipal sewage, was evaluated. This full-scale DHS reactor comprises a polyurethane sponge that retains the sludge. It has a capacity of 500 m3/day and, at the time of this study, had been operating at a sewage treatment plant in India for more than 1,300 days. The DHS reactor was exposed to shock-loadings of organics at double the normal rate for 400 min under summer and winter conditions. The results showed that the DHS reactor maintained stable operation under the organic shock-loading and that it returned to a steady state soon after restart, confirming that the reactor was resilient to organic shock-loadings.


2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Yongjun Zhou ◽  
Yu Zhao ◽  
Hengying Yao ◽  
Yuan Jing

Cracking damage influences the stiffness of the girders. Many articles in the literatures have studied the development of stiffness of the scale-down model; however, full-scale model testing cannot be completely replaced by scale-down testing because of material component characteristics and boundary effects. This paper deals with the effects of cracking damage on the structural static and dynamic stiffness based on three prestressed concrete (PC) girders which were removed from an old bridge. First, the equivalent flexural rigidity of cracked prestressed concrete girder was assessed using the measured load-deflection response under cycles of loading and unloading. Then, after unloading, the frequencies were measured on the PC girders supported by the elastomeric bearings. Next, the development of frequency under different damage was studied, and finally, the dynamic stiffness of PC girders with cracks was assessed. The results indicate that the first frequency is more sensitive to the cracking of concrete compared with the second frequency and that the mode shapes are not sensitive to girder damage. The test girders cannot be simplified as an ideal simply supported beam for the purpose of identifying frequencies. In addition, the “final” (the end of the ultimate load case) equivalent flexural rigidity of the girders is 30% of the “initial” (the beginning of the first load case) equivalent flexural rigidity, compared with 50% in the scale-down test; and the final dynamic stiffness is approximately 84% of the initial dynamic stiffness, whereas the scale-down test is 72%.


2000 ◽  
Vol 16 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Louis M. Hsu ◽  
Judy Hayman ◽  
Judith Koch ◽  
Debbie Mandell

Summary: In the United States' normative population for the WAIS-R, differences (Ds) between persons' verbal and performance IQs (VIQs and PIQs) tend to increase with an increase in full scale IQs (FSIQs). This suggests that norm-referenced interpretations of Ds should take FSIQs into account. Two new graphs are presented to facilitate this type of interpretation. One of these graphs estimates the mean of absolute values of D (called typical D) at each FSIQ level of the US normative population. The other graph estimates the absolute value of D that is exceeded only 5% of the time (called abnormal D) at each FSIQ level of this population. A graph for the identification of conventional “statistically significant Ds” (also called “reliable Ds”) is also presented. A reliable D is defined in the context of classical true score theory as an absolute D that is unlikely (p < .05) to be exceeded by a person whose true VIQ and PIQ are equal. As conventionally defined reliable Ds do not depend on the FSIQ. The graphs of typical and abnormal Ds are based on quadratic models of the relation of sizes of Ds to FSIQs. These models are generalizations of models described in Hsu (1996) . The new graphical method of identifying Abnormal Ds is compared to the conventional Payne-Jones method of identifying these Ds. Implications of the three juxtaposed graphs for the interpretation of VIQ-PIQ differences are discussed.


1996 ◽  
Vol 12 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Louis M. Hsu

The difference (D) between a person's Verbal IQ (VIQ) and Performance IQ (PIQ) has for some time been considered clinically meaningful ( Kaufman, 1976 , 1979 ; Matarazzo, 1990 , 1991 ; Matarazzo & Herman, 1985 ; Sattler, 1982 ; Wechsler, 1984 ). Particularly useful is information about the degree to which a difference (D) between scores is “abnormal” (i.e., deviant in a standardization group) as opposed to simply “reliable” (i.e., indicative of a true score difference) ( Mittenberg, Thompson, & Schwartz, 1991 ; Silverstein, 1981 ; Payne & Jones, 1957 ). Payne and Jones (1957) proposed a formula to identify “abnormal” differences, which has been used extensively in the literature, and which has generally yielded good approximations to empirically determined “abnormal” differences ( Silverstein, 1985 ; Matarazzo & Herman, 1985 ). However applications of this formula have not taken into account the dependence (demonstrated by Kaufman, 1976 , 1979 , and Matarazzo & Herman, 1985 ) of Ds on Full Scale IQs (FSIQs). This has led to overestimation of “abnormality” of Ds of high FSIQ children, and underestimation of “abnormality” of Ds of low FSIQ children. This article presents a formula for identification of abnormal WISC-R Ds, which overcomes these problems, by explicitly taking into account the dependence of Ds on FSIQs.


Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
PE Ebong ◽  
HP Onyeama ◽  
MU Eteng ◽  
GO Igile ◽  
GE Egbung
Keyword(s):  

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