Peptide histidine valine-42 stimulates gastric acid secretion in man

1989 ◽  
Vol 9 (3) ◽  
pp. 369-374 ◽  
Author(s):  
G. C. Nikou ◽  
Y. Yiangou ◽  
B. J. Chrysanthou ◽  
J. Domin ◽  
S. R. Bloom
Keyword(s):  
Gastric Secretion ◽  
Acid Secretion ◽  
Healthy Volunteers ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Local Control ◽  
Significant Stimulation ◽  
New Finding ◽  
Stimulation Of

The effect of peptide histidine valine-42 (PHV-42) on gastric acid secretion was studied in man. PHV-42 was infused into 5 healthy volunteers at a dose of 10 pmol/kg/min. This dose caused a significant stimulation of basal gastric acid and potassium output. there were no significant changes in circulating gastrin throughout the infusion. In 2 subjects with a background of submaximal pentagastrin stimulation, PHV-42 infusion at the same dose did not alter acid secretion in either subject. The previous observation that PHV-42 is found particularly in the stomach and the new finding that it stimulates basal gastric secretion suggest the possibility that PHV-42 could have a role in local control of acid secretion.

Stimulation of gastric acid secreted by glycine and related oligopeptides in humans

1982 ◽  
Vol 242 (2) ◽  
pp. G85-G88
Author(s):  
A. Wald ◽  
S. A. Adibi
Keyword(s):  
Small Intestine ◽  
Gastric Secretion ◽  
Acid Secretion ◽  
Healthy Volunteers ◽  
Gastric Acid ◽  
Serum Gastrin ◽  
Physiological Saline ◽  
Glycine Concentration ◽  
Glycine Content ◽  
Stimulation Of

To investigate the effect of oligopeptides on gastric secretion in humans, we investigated acid secretion in healthy volunteers after the intragastric infusion of physiological saline, glycine (100 mM), diglycine (50 mM), triglycine (33 mM), and tetraglycine (25 mM). All test solutions were equivalent in glycine content, osmolality (300 mosmol), and pH (5.5). Although the rate of acid secretion was greater during glycine than saline infusion [5.6 +/- 0.8 vs. 3.3 +/- 1.1 mmol/h (means +/- SE); P less than 0.05], the rate of acid secretion during glycine infusion was not significantly different from that induced by its related peptides. There were increases in plasma glycine concentration during infusion of glycine and its related peptides but no detectable changes in serum gastrin levels. The increases in plasma glycine must have been due to absorption from the small intestine because there was no gastric absorption of glycine in free or dipeptide form nor diglycine hydrolysis in the stomach. Therefore, our results permit implicating only the increased plasma glycine concentrations as the stimulus for acid secretion by glycine and its homologous peptides.

Electrical stimulation of the medial amygdala facilitates gastric acid secretion in conscious rats

1990 ◽  
Vol 524 (2) ◽  
pp. 208-212 ◽  
Author(s):  
Myung Suk Kim ◽  
Yang Hyeok Jo ◽  
Shin Hee Yoon ◽  
Sang June Hahn ◽  
Duck Joo Rhie ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Medial Amygdala ◽  
Conscious Rats ◽  
Stimulation Of

Effect of thyroid on gastric secretion and metabolism

1961 ◽  
Vol 201 (3) ◽  
pp. 567-570 ◽  
Author(s):  
E. S. Nasset ◽  
Dale P. J. Goldsmith
Keyword(s):  
Oxygen Consumption ◽  
Gastric Mucosa ◽  
Gastric Secretion ◽  
Thyroid Hormones ◽  
Acid Secretion ◽  
Gastric Acid Secretion ◽  
Gastric Acid ◽  
Early Summer ◽  
Tissue Concentrations ◽  
Oxygen Ratio

The effect of administration of thyroid products on gastric acid secretion and metabolism was studied in dogs with gastric pouches and in gastric mucosa from rats and frogs. Whole thyroid, thyroxin, triiodothyronine, and iodinated casein generally reduced secretion in thyroidectomized dogs and in dogs with intact thyroids. The thyroid substances elevated BMR above euthyroid levels in normal dogs but not always in thyroidectomized dogs. In dogs with intact thyroids 2,4-dinitrophenol raised oxygen consumption but did not affect secretion. Whole thyroid elevated BMR in rats and frogs but did not change resting mucosal oxygen consumption. During spring and early summer thyroid feeding reduced histamine-stimulated acid secretion and mucosal oxygen consumption during secretion in frogs, but the acid-to-oxygen ratio was unaffected. These findings suggest that elevated tissue concentrations of thyroid hormones reduce the ability of the gastric mucosa to mobilize secretory energy in response to a stimulus. This effect of the thyroid hormones is apparently not directly correlated with their calorigenic properties.

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