Dexniguldipine hydrochloride, a protein-kinase-C-specific inhibitor, affects the cell cycle, differentiation, P-glycoprotein levels, and nuclear protein phosphorylation in friend erythroleukemia cells

1996 ◽  
Vol 122 (8) ◽  
pp. 465-475 ◽  
Author(s):  
K. K. Patterson ◽  
B. S. Beckman ◽  
D. M. Klotz ◽  
C. M. Mallia ◽  
J. R. Jeter
Keyword(s):  
Cell Cycle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Phosphorylation ◽  
Nuclear Protein ◽  
Specific Inhibitor ◽  
Kinase C ◽  
P Glycoprotein ◽  
Erythroleukemia Cells ◽  
Friend Erythroleukemia Cells

Protein kinase C β from Friend erythroleukemia cells is associated with chromatin and DNA

1995 ◽  
Vol 151 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Conrad M. Mallia ◽  
James R. Jeter ◽  
Alan P. Fields ◽  
Russell B. Wilson ◽  
Barbara S. Beckman
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Kinase C ◽  
Erythroleukemia Cells ◽  
Friend Erythroleukemia Cells

Protein kinase C ? nuclear translocation mediates the occurrence of radioresistance in friend erythroleukemia cells

2002 ◽  
Vol 88 (1) ◽  
pp. 144-151 ◽  
Author(s):  
A. Cataldi ◽  
L. Centurione ◽  
R. Di Pietro ◽  
M. Rapino ◽  
D. Bosco ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Nuclear Translocation ◽  
Kinase C ◽  
Erythroleukemia Cells ◽  
Friend Erythroleukemia Cells

Nuclear Protein Kinase C-δ: A Possible Check-Point of Cell Cycle Progression

2006 ◽  
Vol 19 (2) ◽  
pp. 287-291 ◽  
Author(s):  
M. Marchisio ◽  
V. Bertagnolo ◽  
P. Lanuti ◽  
A.R. Gaspari ◽  
M. Paludi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Cycle Progression ◽  
Nuclear Protein ◽  
Check Point ◽  
Cycle Progression ◽  
Kinase C

Generation of diacylglycerol molecular species through the cell cycle: a role for 1-stearoyl, 2-arachidonyl glycerol in the activation of nuclear protein kinase C-βII at G2/M

2002 ◽  
Vol 115 (5) ◽  
pp. 983-989 ◽  
Author(s):  
Elizabeth M. Deacon ◽  
Trevor R. Pettitt ◽  
Paul Webb ◽  
Timothy Cross ◽  
Hema Chahal ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Nuclear Protein ◽  
Nuclear Translocation ◽  
Nuclear Targeting ◽  
Kinase C ◽  
M Phase

Protein kinase C (PKC) is a family of 11 isoenzymes that are differentially involved in the regulation of cell proliferation. PKC-βII, a mitotic lamin kinase, has been shown previously to translocate to the nucleus at G2/M and this was coupled to the generation of nuclear diacylglycerol. However, it is not clear how isoenzyme selective translocation and nuclear targeting is achieved during cell cycle. To investigate further the role of nuclear diacylglycerol we measured PKC isoenzyme translocation and analysed diacylglycerol species at different stages of the cell cycle in U937 cells synchronized by centrifugal elutriation. Translocation of PKC-βII to the membrane fraction, an indicator of activation, occurred at S and G2/M, although PKC-βII was targeted to the nucleus only at G2/M. Levels of nuclear diacylglycerol, specifically tetraunsaturated species, increased during G2/M. By contrast, there were no obvious changes in nuclear phosphatidic acid species or mass. 1-stearoyl, 2-arachidonyl glycerol (SAG), the major polyunsaturated nuclear diacylglycerol, was able to activate classical PKC isoenzymes (PKC-α andβ), but was less effective for activation of novel isoenzymes(PKC-δ), in an in vitro PKC assay. We propose that PKC-βII nuclear translocation during G2/M phase transition is mediated in part by generation of SAG at the nucleus.

scholarly journals Iron-responsive element-binding protein. Phosphorylation by protein kinase C.

1993 ◽  
Vol 268 (36) ◽  
pp. 27363-27370
Author(s):  
R S Eisenstein ◽  
P T Tuazon ◽  
K L Schalinske ◽  
S A Anderson ◽  
J A Traugh
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Protein Phosphorylation ◽  
Binding Protein ◽  
Iron Responsive Element ◽  
Kinase C ◽  
Element Binding Protein ◽  
Responsive Element
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