Autonomic nervous system involvement in experimental genital infection by herpes simplex virus type 2

1986 ◽  
Vol 91 (3-4) ◽  
pp. 329-339 ◽  
Author(s):  
N. A. Sanjuan ◽  
E. F. Lascano
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Genital Infection ◽  
System Involvement ◽  
Simplex Virus

Virus spread and initial pathological changes in the nervous system in genital herpes simplex virus type 2 infection in mice

1987 ◽  
Vol 72 (4) ◽  
pp. 377-388 ◽  
Author(s):  
G. Georgsson ◽  
J. R. Martin ◽  
G. L. Stoner ◽  
H. de F. Webster
Keyword(s):  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Genital Herpes ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Virus Spread ◽  
Pathological Changes ◽  
Simplex Virus

Genital Reinfection After Recovery from Initial Genital Infection with Herpes Simplex Virus Type 2 in Guinea Pigs

1986 ◽  
Vol 153 (6) ◽  
pp. 1055-1061 ◽  
Author(s):  
L. R. Stanberry ◽  
D. I. Bernstein ◽  
S. Kit ◽  
M. G. Myers
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Guinea Pigs ◽  
Genital Infection ◽  
Simplex Virus

scholarly journals Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Gerit Korr ◽  
Michael Thamm ◽  
Irina Czogiel ◽  
Christina Poethko-Mueller ◽  
Viviane Bremer ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Genital Infection ◽  
Infection Time ◽  
Simplex Virus

A vaccine containing highly purified virus particles in adjuvant provides high level protection against genital infection and disease in guinea pigs challenged intravaginally with homologous and heterologous strains of herpes simplex virus type 2

Vaccine ◽  
2020 ◽  
Vol 38 (1) ◽  
pp. 79-89 ◽  
Author(s):  
David I. Bernstein ◽  
Christopher S. Morello ◽  
Rhonda D. Cardin ◽  
Fernando J. Bravo ◽  
Kimberly A. Kraynyak ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Guinea Pigs ◽  
Genital Infection ◽  
Virus Particles ◽  
Simplex Virus ◽  
High Level

scholarly journals Detection of herpes simplex virus type 2 (HSV-2) -specific cell-mediated immune responses in guinea pigs during latent HSV-2 genital infection

2016 ◽  
Vol 439 ◽  
pp. 1-7 ◽  
Author(s):  
Clarice L. Perry ◽  
Brianne N. Banasik ◽  
Summer R. Gorder ◽  
Jingya Xia ◽  
Sarah Auclair ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Immune Responses ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Guinea Pigs ◽  
Genital Infection ◽  
Specific Cell ◽  
Simplex Virus

scholarly journals Neutrophils Aid in Protection of the Vaginal Mucosae of Immune Mice against Challenge with Herpes Simplex Virus Type 2

1999 ◽  
Vol 73 (8) ◽  
pp. 6380-6386 ◽  
Author(s):  
Gregg N. Milligan
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Cell Function ◽  
Genital Infection ◽  
Vaginal Mucosa ◽  
Simplex Virus

ABSTRACT Large numbers of polymorphonuclear leukocytes (PMNs) infiltrated the murine vaginal mucosa within 24 h after intravaginal inoculation with an attenuated strain of herpes simplex virus type 2 (HSV-2). The role of these cells in resolution of a primary genital infection and in protection of HSV-immune animals against challenge with a fully virulent HSV-2 strain was investigated. Depletion of greater than 95% of the PMNs at the vaginal mucosal surface prior to intravaginal inoculation with an attenuated HSV-2 strain resulted in significantly higher virus titers on days 3 to 7 but only slightly delayed resolution of the primary genital infection. These results suggest that neutrophils helped control the infection but that other immune mechanisms ultimately cleared the virus. Interestingly, depletion of PMNs from HSV-immune mice prior to challenge with a fully virulent HSV-2 strain resulted in a rise in virus titers to levels comparable to those of nonimmune mice and a more pronounced diminution of virus clearance from the vaginal mucosa despite the presence of HSV-specific B and T cells. Levels of gamma interferon (IFN-γ) and HSV-specific antibody were comparable in neutrophil-depleted and control-treated immune mice following HSV-2 challenge, suggesting that RB6-8C5 treatment did not impair T- and B-cell function. Therefore, these results suggest that neutrophils play a role in limiting and clearing HSV-2 vaginal infections and that they are, in association with HSV-specific B and T cells, an important component in immune protection of the vaginal mucosa.

Sign in / Sign up

Export Citation Format

Share Document