Clinical outcome and cognitive impairment in patients with severe head injuries treated with barbiturate coma

1992 ◽  
Vol 117 (3-4) ◽  
pp. 153-159 ◽  
Author(s):  
W. Schal�n ◽  
B. Sonesson ◽  
K. Messeter ◽  
G. Nordstr�m ◽  
C. -H. Nordstr�m
Keyword(s):  
Cognitive Impairment ◽  
Clinical Outcome ◽  
Head Injuries ◽  
Barbiturate Coma

scholarly journals Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal

Neurology ◽  
2019 ◽  
Vol 92 (23) ◽  
pp. e2699-e2705
Author(s):  
Lisa Vermunt ◽  
Alegría J.L. van Paasen ◽  
Charlotte E. Teunissen ◽  
Philip Scheltens ◽  
Pieter Jelle Visser ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Clinical Outcome ◽  
Amyloid Pet ◽  
Clinical Markers ◽  
Disease Biomarkers ◽  
Imaging Markers ◽  
Normal Cognition

ObjectiveTo identify potential predictors for outcome in individuals with mild cognitive impairment (MCI) who have reverted to normal cognition (NC).MethodsWe selected individuals with MCI, who reverted at follow-up to NC, with follow-up after reversion from Alzheimer's Disease Neuroimaging Initiative. Common clinical markers, Alzheimer disease (AD) biomarkers, and neurodegeneration imaging markers were used to compare MCI reverters based on subsequent clinical outcome (i.e., subsequent decline or stable reversion). For independent comparison, findings of the clinical Amsterdam Dementia Cohort are presented.ResultsSeventy-seven (10%) out of 757 individuals with MCI reverted to NC and 61 of these individuals had follow-up data available. After 3.2 ± 2.2 years, 16 (24%) progressed to MCI, and 3 (5%) to dementia. Those who declined were older and had a higher amyloid PET burden and higher CSF tau levels.ConclusionIn MCI reverters, abnormal biomarkers for AD pathology are associated with subsequent decline. AD biomarkers may aid in the prognosis of reverting MCI.

P1-315: The usefulness of amyloid-imaging in predicting the clinical outcome of patients with mild cognitive impairment

2011 ◽  
Vol 7 ◽  
pp. S212-S212
Author(s):  
Timo Grimmer ◽  
Carolin Wutz ◽  
Hans Förstl ◽  
Alexander Kurz ◽  
Alexander Drzezga
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Outcome ◽  
Amyloid Imaging

scholarly journals Detection of Midline Shift from CT Scans to Predict Outcome in Patients with Head Injuries

2021 ◽  
Vol 11 (1) ◽  
pp. 18-23
Author(s):  
Ikhlas Abdelaziz ◽  
Rowa Aljondi ◽  
Ali Alhailiy ◽  
Mustafa Mahmoud
Keyword(s):  
Clinical Outcome ◽  
Brain Injuries ◽  
Head Injuries ◽  
Clinical Status ◽  
Ct Scans ◽  
Ct Scanner ◽  
Midline Shift ◽  
Medical Systems ◽  
Gcs Score ◽  
The Relationship

Background: The present study aimed to detect the degree of midline shift from CT scans and the clinical status of the patient, to evaluate the relationship between the degree of midline shift found by the CT scan and GCS score as a predictor of clinical outcome in head injury patients. Furthermore, we aimed to assess the relationship between midline shift and age, sex, and causes. Methods and Results: The study included 50 subjects (36 males and 14 females). The age range of the patients in this study was 18–95 years old (mean age of 48.34±17.02 years). The inclusion criteria were patients with traumatic brain injury (TBI) or patients evaluated for level of consciousness by a neurosurgeon. Toshiba 16 Slice CT scanner (Toshiba Medical Systems, Nasu, Japan 2003) was used to scan all patients in the supine, head first position. Contiguous 2 mm slices were obtained using the Toshiba 16-slice machine spiral technique (pitch 1.25–1.5, 0.75 s rotation time, 120 KvP, 2 mm reconstruction interval). The results indicated that the degree of midline shift in patients with brain injuries was statistically significant as a determinant of clinical outcome. It appeared that the probability of poor clinical outcome was higher when there was a combination of midline shift and other types of intracranial hemorrhage, clinical factors, such as sex, age, and GCS score, and associated injuries. The worst outcome was seen in patients with midline shift and subdural hematoma, when compared with other lesions in patients with brain injuries. Conclusion: This study suggests that the degree of midline shift may be predictive of clinical outcome in patients with head injuries.

Familiarity in Mild Cognitive Impairment as a Function of Patients’ Clinical Outcome 4 Years Later

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Christine Bastin ◽  
Mohamed A. Bahri ◽  
Fabrice Giacomelli ◽  
Frédéric Miévis ◽  
Christian Lemaire ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Outcome

Controlled lumbar drainage in pediatric head injury

1995 ◽  
Vol 83 (3) ◽  
pp. 453-460 ◽  
Author(s):  
David I. Levy ◽  
Harold L. Rekate ◽  
W. Bruce Cherny ◽  
Kim Manwaring ◽  
S. David Moss ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Head Injury ◽  
Pediatric Patients ◽  
Head Injuries ◽  
Severe Disabilities ◽  
Barbiturate Coma ◽  
Content Type ◽  
Lumbar Drainage ◽  
Pediatric Head Injury ◽  
Lumbar Drain

✓ A retrospective study of external lumbar subarachnoid drainage in 16 pediatric patients with severe head injuries is presented. All patients had Glasgow Coma Scale scores of 8 or lower at 6 hours postinjury and were initially treated with ventriculostomy. Five patients required surgical evacuation of focal mass lesions. All patients manifested high intracranial pressures (ICPs) refractory to aggressive therapy, including hyperventilation, furosemide, mannitol, and in some cases, artificially induced barbiturate coma. After lumbar drainage was instituted, 14 patients had an abrupt and lasting decrease in ICP, obviating the need for continued medical management of ICP. In no patient did transtentorial or cerebellar herniation occur as a result of lumbar drainage. It was also noted retrospectively that the patients in this study had discernible basilar cisterns on computerized tomography scans. Fourteen patients survived; eight made good recoveries, three are functional with disability, and three have severe disabilities. Two patients died, most likely from uncontrolled ICP before the lumbar drain was placed. It is concluded that controlled external lumbar subarachnoid drainage is a useful treatment for pediatric patients with severe head injury when aggressive medical therapy and ventricular cerebrospinal fluid evacuation have failed to control high ICP. Selected patients with elevated ICP, which may be a function of posttraumatic cerebrospinal fluid circulation disruption and/or white matter cerebral edema, can be treated with this modality, which accesses the cisternal spaces untapped by ventriculostomy.

scholarly journals Prediction of poor clinical outcome in vascular cognitive impairment: TRACE‐VCI study

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Jooske M.F. Boomsma ◽  
Lieza G. Exalto ◽  
Frederik Barkhof ◽  
Christopher L.H. Chen ◽  
Saima Hilal ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Clinical Outcome ◽  
Vascular Cognitive Impairment ◽  
Poor Clinical Outcome

The Usefulness of Amyloid Imaging in Predicting the Clinical Outcome After Two Years in Subjects with Mild Cognitive Impairment

2013 ◽  
Vol 10 (1) ◽  
pp. 82-85 ◽  
Author(s):  
Timo Grimmer ◽  
Carolin Wutz ◽  
Alexander Drzezga ◽  
Stefan Forster ◽  
Hans Forstl ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Clinical Outcome ◽  
Amyloid Imaging
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