Alcian blue staining intestinal goblet cell antigen (GOA): A Marker for gastric signet ring cell and colonic colloidal carcinoma

1978 ◽  
Vol 56 (23) ◽  
pp. 1185-1187 ◽  
Author(s):  
W. Rapp ◽  
K. Wurster
Keyword(s):  
Alcian Blue ◽  
Goblet Cell ◽  
Signet Ring Cell ◽  
Blue Staining ◽  
Alcian Blue Staining ◽  
Cell Antigen ◽  
Signet Ring ◽  
Ring Cell

Goblet Cell Mimickers in Esophageal Biopsies Are Not Associated With an Increased Risk for Dysplasia

2007 ◽  
Vol 131 (4) ◽  
pp. 571-575
Author(s):  
Mamoun Younes ◽  
Atilla Ertan ◽  
Gulchin Ergun ◽  
Ray Verm ◽  
Margaret Bridges ◽  
...  
Keyword(s):  
Alcian Blue ◽  
Goblet Cell ◽  
Significant Risk ◽  
Goblet Cells ◽  
Intestinal Type ◽  
Blue Staining ◽  
Alcian Blue Staining ◽  
Increased Risk ◽  
Original Report ◽  
Hematoxylin Eosin

Abstract Context.—Identification of intestinal-type goblet cells (ITGCs) in hematoxylin-eosin–stained sections of esophageal biopsies is essential for the diagnosis of Barrett metaplasia. However, we have seen cases diagnosed as Barrett metaplasia based solely on cells that pose morphologic similarity to ITGCs on hematoxylin-eosin staining or stain positive with Alcian blue. Objective.—To determine the clinical significance of goblet cell mimickers. Design.—Initial biopsies from 78 patients with original diagnosis of Barrett metaplasia negative for dysplasia and a mean follow-up of 72 months were reviewed and reclassified into 3 categories: (1) ITGCs, (2) goblet cell mimickers, or (3) neither. Sections from available paraffin blocks were stained with Alcian blue at pH 2.5. The presence of the different types of cells and positive Alcian blue staining were correlated with each other and evaluated for their significance as predictors of progression to dysplasia. Results.—Goblet cell mimickers were present in 35 cases and were associated with ITGCs in the same biopsy in 23 (66%) of these cases. Intestinal-type goblet cells were present in 56 cases, and the remaining 10 cases, although called Barrett on the original report, did not show either ITGCs or goblet cell mimickers. Only the presence of ITGCs was associated with significant risk for dysplasia (P = .008). Positive Alcian blue staining was not associated with a significant risk for dysplasia. Conclusions.—Our results indicate that the diagnosis of Barrett metaplasia should be rendered with confidence only when ITGCs are identified on routine hematoxylin-eosin–stained sections.

Adenocarcinoma Ex–Goblet Cell Carcinoid of the Appendix With Metastatic Peritoneal Spread to Meckel’s Diverticulum and Endometriosis

2017 ◽  
Vol 25 (7) ◽  
pp. 623-628 ◽  
Author(s):  
Brett Matthew Lowenthal ◽  
Grace Y. Lin ◽  
Ann M. Ponsford Tipps ◽  
Mojgan Hosseini
Keyword(s):  
Goblet Cell ◽  
Meckel’S Diverticulum ◽  
Signet Ring Cell ◽  
Meckel's Diverticulum ◽  
Goblet Cell Carcinoid ◽  
Cell Type ◽  
Lower Quadrant ◽  
Signet Ring ◽  
Ring Cell ◽  
Peritoneal Spread

Adenocarcinoma ex–goblet cell carcinoid is a very rare and histologically unique appendiceal malignancy with dual glandular and neuroendocrine differentiation. There is a high incidence of this tumor among middle-aged women with metastasis to the gynecologic tract with the mode of metastasis following peritoneal spread rather than hematogenous distribution. Adenocarcinoma ex-goblet cell carcinoid can spread to any peritoneal site including ovaries or omentum. We report a 37-year-old healthy woman who initially presented with right lower quadrant abdominal pain and pseudomyxoma peritonei. Histopathology of the appendectomy specimen revealed an adenocarcinoma ex-goblet cell carcinoid, signet ring cell type. Follow-up right hemicolectomy, omentectomy, bilateral salpingo-oophorectomy, and regional peritoneal resections revealed metastatic involvement by adenocarcinoma ex–goblet cell carcinoid, signet ring cell type. In this report, we describe a case of appendiceal adenocarcinoma ex goblet cell carcinoid with metastases to Meckel’s diverticulum and areas of pelvic endometriosis, which have not been previously reported.

Cytological features of signet-ring cell carcinoma of the lung: Comparison with the goblet-cell-type adenocarcinoma of the lung

2009 ◽  
Vol 37 (3) ◽  
pp. 159-163 ◽  
Author(s):  
Koji Tsuta ◽  
Yasuo Shibuki ◽  
Naoki Maezawa ◽  
Naobumi Tochigi ◽  
Akiko Miyagi Maeshima ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Goblet Cell ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Cell Type ◽  
Adenocarcinoma Of The Lung ◽  
Signet Ring ◽  
Cytological Features ◽  
Ring Cell

Acute Appendicitis with Neuronal Hyperplasia and Swelling: A Novel Histologic Mimic of Appendiceal Goblet Cell Adenocarcinoma and Signet-Ring Cell Adenocarcinoma

2021 ◽  
pp. 106689692110479
Author(s):  
Anupam Mitra ◽  
Han S. Lee ◽  
Karen Matsukuma
Keyword(s):  
Acute Appendicitis ◽  
Goblet Cell ◽  
Ganglion Cells ◽  
Close Association ◽  
Signet Ring Cell ◽  
Cell Hyperplasia ◽  
Signet Ring Cell Adenocarcinoma ◽  
Signet Ring ◽  
Benign Process ◽  
Ring Cell

Goblet cell adenocarcinoma and signet-ring cell adenocarcinoma are well-known diagnostic pitfalls of routine appendectomy specimens. Here we present a case of acute appendicitis with prominent neuronal (ganglion cell) hyperplasia and swelling which histologically mimics goblet cell adenocarcinoma and signet-ring cell adenocarcinoma. Attention to the cytologic features of the lesional cells (absence of atypia, mitotic activity) and their close association with nerves and classic ganglion cells, along with the use of a limited panel of immunostains, ensures proper classification of this rare but striking benign process.

Ovarian Metastases of Appendiceal Tumors With Goblet Cell Carcinoidlike and Signet Ring Cell Patterns

2007 ◽  
Vol 31 (10) ◽  
pp. 1502-1511 ◽  
Author(s):  
Alexandra C. Hristov ◽  
Robert H. Young ◽  
Russell Vang ◽  
Anna V. Yemelyanova ◽  
Jeffrey D. Seidman ◽  
...  
Keyword(s):  
Goblet Cell ◽  
Signet Ring Cell ◽  
Ovarian Metastases ◽  
Signet Ring ◽  
Cell Patterns ◽  
Ring Cell

Cervical and Endometrial Metastases of Appendiceal Goblet Cell Carcinoid

2010 ◽  
Vol 134 (5) ◽  
pp. 776-780
Author(s):  
Zenggang Pan ◽  
Susan Repertinger ◽  
Ronald Leonard ◽  
Chhanda Bewtra ◽  
Zoran Gatalica ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Goblet Cell ◽  
Abnormal Uterine Bleeding ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Goblet Cell Carcinoid ◽  
Clinical Investigations ◽  
Signet Ring ◽  
Ring Cell ◽  
Cervical Involvement

Abstract Appendiceal goblet cell carcinoid (GCC) is a rare tumor with histologic features of both adenocarcinoma and neuroendocrine tumor (carcinoid). Clinically, it behaves more aggressively than classic appendiceal carcinoid and commonly presents with peritoneal carcinomatosis. We report 2 cases of appendiceal GCC, one with uterine cervical involvement and the other with endometrial involvement as the initial presentations. The first patient's invasive cervical signet ring cell carcinoma was diagnosed on routine screening. The second patient presented with abnormal uterine bleeding, and endometrial curettage showed an adenocarcinoma with signet ring cell features. Primary appendiceal GCC was demonstrated in both cases after systematic clinical investigations. Metastatic appendiceal GCC to uterine cervix and endometrium can potentially be misinterpreted as primary cervical or endometrial signet ring cell carcinoma. Therefore, for any uterine cervical/endometrial signet ring cell carcinoma, a metastatic appendiceal GCC should be considered in the differential diagnosis, especially after excluding other primary sites.

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