Phenotype and surface antigens of mouse teratocarcinoma � fibroblast cell hybrids

1979 ◽  
Vol 5 (6) ◽  
pp. 739-752 ◽  
Author(s):  
Jean -Pierre Rousset ◽  
Philippe Dubois ◽  
Chantal Lasserre ◽  
Dominique Avil�s ◽  
Marc Fellous ◽  
...  
Keyword(s):  
Fibroblast Cell ◽  
Surface Antigens ◽  
Cell Hybrids ◽  
Mouse Teratocarcinoma

Developmental potentialities and surface antigens of mouse teratocarcinoma x lymphoid cell hybrids

1980 ◽  
Vol 6 (3) ◽  
pp. 419-433 ◽  
Author(s):  
Jean -Pierre Rousset ◽  
Jacques Jami ◽  
Philippe Dubois ◽  
Dominique Avil�s ◽  
Evelyne Ritz
Keyword(s):  
Lymphoid Cell ◽  
Surface Antigens ◽  
Cell Hybrids ◽  
Mouse Teratocarcinoma

Activation and repression of a beta-globin gene in cell hybrids is accompanied by a shift in its temporal replication

1989 ◽  
Vol 9 (8) ◽  
pp. 3524-3532
Author(s):  
V Dhar ◽  
A I Skoultchi ◽  
C L Schildkraut
Keyword(s):  
Cell Line ◽  
Hybrid Cell ◽  
Globin Gene ◽  
Fibroblast Cell ◽  
Globin Genes ◽  
Fibroblast Cell Line ◽  
Beta Globin ◽  
Hybrid Cells ◽  
Beta Globin Gene ◽  
Cell Hybrids

To investigate whether a switch in the transcriptional activity of a gene is associated with a change in the timing of replication during the S phase, we examined the replication timing of the beta-globin genes in two different types of somatic cell hybrids. In mouse hepatoma (Hepa 1a) x mouse erythroleukemia (MEL) hybrid cells, the beta-globin gene from the MEL parent is transcriptionally inactivated and is later replicating than in the parental MEL cell line. In human fibroblast (GM3552) x MEL hybrid cells, the human beta-globin gene is transcriptionally activated, and all of the sequences within the human beta-globin domain (200 kilobases) we have examined appear to be earlier replicating than those in the parental fibroblast cell line. The chromatin configuration of the activated human beta-globin domain in the hybrids is relatively more sensitive to nucleases than that in the fibroblasts. Furthermore, major nuclease-hypersensitive sites that were absent in the chromatin flanking the distal 5' region of the human beta-globin gene cluster in the parental fibroblast cell line are present in the transcriptionally activated domain in the hybrid cell line. These results suggest that timing of replication of globin genes has been altered in these hybrid cells and thus is not fixed during the process of differentiation.

Phenotypic Expression in T-Lymphocyte x “Fibroblast” Cell Hybrids

1979 ◽  
pp. 224-231
Author(s):  
N. Saravia ◽  
R. I. DeMars ◽  
F. J. Bollum ◽  
F. H. Bach
Keyword(s):  
T Lymphocyte ◽  
Phenotypic Expression ◽  
Fibroblast Cell ◽  
Cell Hybrids

scholarly journals Extinction of expression of the genes encoding haematopoietic cell-restricted transcription factors in T-lymphoma x fibroblast cell hybrids

Immunology ◽  
2001 ◽  
Vol 104 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Tsuneyuki Oikawa ◽  
Toshiyuki Yamada ◽  
Nobuo Kondoh ◽  
Fumiko Negishi-Kihara ◽  
Yoshiaki Hitomi ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Fibroblast Cell ◽  
Cell Hybrids ◽  
Haematopoietic Cell ◽  
Genes Encoding ◽  
T Lymphoma

Production of interspecies T cell hybrids which retain differentiation specific surface antigens

1983 ◽  
Vol 62 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Pamela G. Messer Peters ◽  
Michael E. Kamarck ◽  
Frank H. Ruddle
Keyword(s):  
T Cell ◽  
Specific Surface ◽  
Surface Antigens ◽  
Cell Hybrids
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