Biochemical genetics of the mammalian oxidative phosphorylation system: Analysis of the difference in the sensitivity of various Chinese hamster cell lines to inhibitors of the mitochondrial ATP synthase complex

1983 ◽  
Vol 9 (5) ◽  
pp. 549-566 ◽  
Author(s):  
William A. Simmons ◽  
Gail A. M. Breen
Keyword(s):  
Oxidative Phosphorylation ◽  
Cell Lines ◽  
Atp Synthase ◽  
System Analysis ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Biochemical Genetics ◽  
Oxidative Phosphorylation System ◽  
Mitochondrial Atp Synthase ◽  
The Difference

scholarly journals The ATP Synthase Deficiency in Human Diseases

Life ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 325
Author(s):  
Chiara Galber ◽  
Stefania Carissimi ◽  
Alessandra Baracca ◽  
Valentina Giorgio
Keyword(s):  
Oxidative Phosphorylation ◽  
Atp Synthase ◽  
Mitochondrial Protein ◽  
High Energy ◽  
Neurocognitive Disorders ◽  
Human Diseases ◽  
Age Related ◽  
Muscle Tissues ◽  
Mitochondrial Atp Synthase ◽  
Genes Encoding

Human diseases range from gene-associated to gene-non-associated disorders, including age-related diseases, neurodegenerative, neuromuscular, cardiovascular, diabetic diseases, neurocognitive disorders and cancer. Mitochondria participate to the cascades of pathogenic events leading to the onset and progression of these diseases independently of their association to mutations of genes encoding mitochondrial protein. Under physiological conditions, the mitochondrial ATP synthase provides the most energy of the cell via the oxidative phosphorylation. Alterations of oxidative phosphorylation mainly affect the tissues characterized by a high-energy metabolism, such as nervous, cardiac and skeletal muscle tissues. In this review, we focus on human diseases caused by altered expressions of ATP synthase genes of both mitochondrial and nuclear origin. Moreover, we describe the contribution of ATP synthase to the pathophysiological mechanisms of other human diseases such as cardiovascular, neurodegenerative diseases or neurocognitive disorders.

scholarly journals Cold sensitivity of mitochondrial ATP synthase restricts oxidative phosphorylation in Arabidopsis thaliana

2018 ◽  
Vol 221 (4) ◽  
pp. 1776-1788 ◽  
Author(s):  
Sandra M. Kerbler ◽  
Nicolas L. Taylor ◽  
A. Harvey Millar
Keyword(s):  
Arabidopsis Thaliana ◽  
Oxidative Phosphorylation ◽  
Atp Synthase ◽  
Cold Sensitivity ◽  
Mitochondrial Atp Synthase

scholarly journals Nucleolus organizer regions in diploid and heteroploid chinese hamster cell lines.

CYTOLOGIA ◽  
1981 ◽  
Vol 46 (4) ◽  
pp. 809-816 ◽  
Author(s):  
L. G. Weide ◽  
V. G. Dev ◽  
C. S. Rupert
Keyword(s):  
Cell Lines ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Nucleolus Organizer ◽  
Nucleolus Organizer Regions

scholarly journals Molecular genetics of complex I-deficient Chinese hamster cell lines

2004 ◽  
Vol 1659 (2-3) ◽  
pp. 160-171 ◽  
Author(s):  
Immo E. Scheffler ◽  
Nagendra Yadava ◽  
Prasanth Potluri
Keyword(s):  
Molecular Genetics ◽  
Cell Lines ◽  
Complex I ◽  
Chinese Hamster ◽  
Chinese Hamster Cell

Butyrate effect on nuclear proteins of two Chinese hamster cell lines

1988 ◽  
Vol 174 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Vincenzo Giancotti ◽  
Bianca Pani ◽  
Paola D'Andrea ◽  
Peter Symmons
Keyword(s):  
Cell Lines ◽  
Chinese Hamster ◽  
Chinese Hamster Cell ◽  
Nuclear Proteins
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