Epidermal growth factor receptor and c-erbB-2 expression in normal breast tissue during the menstrual cycle

1996 ◽  
Vol 38 (2) ◽  
pp. 227-235 ◽  
Author(s):  
A. Gompel ◽  
A. Martin ◽  
P. Simon ◽  
D. Schöevaert ◽  
G. Plu-Bureau ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Menstrual Cycle ◽  
Epidermal Growth Factor ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Growth Factor Receptor ◽  
Normal Breast ◽  
Epidermal Growth

scholarly journals Differential expression of the epidermal growth factor receptor in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Differential Expression ◽  
Growth Factor Receptor ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Epidermal Growth

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the epidermal growth factor receptor, EGFR, when comparing primary tumors of the breast to the tissue of origin, the normal breast. EGFR mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of EGFR in primary tumors of the breast was correlated with overall survival in patients with luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. EGFR may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Changes in Epidermal Growth Factor Receptor and the Levels of its Ligands during Menstrual Cycle in Human Endometrium

1995 ◽  
Vol 52 (4) ◽  
pp. 928-938 ◽  
Author(s):  
Takashi Imai ◽  
Hirohisa Kurachi ◽  
Kazushige Adachi ◽  
Hiroshi Adachi ◽  
Yasuhiro Yoshimoto ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Menstrual Cycle ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Human Endometrium ◽  
Epidermal Growth
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