Long-term follow up of patients with common variable immunodeficiency treated with intravenous immunoglobulin: Reevaluation of intravenous immunoglobulin replacement therapy

Biotherapy ◽  
1993 ◽  
Vol 7 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Kyosuke Mushiake ◽  
Fumiaki Motoyoshi ◽  
Naomi Kondo ◽  
Hiroyuki Shimizu ◽  
Tadao Orii
Keyword(s):  
Replacement Therapy ◽  
Intravenous Immunoglobulin ◽  
Common Variable Immunodeficiency ◽  
Immunoglobulin Replacement Therapy ◽  
Long Term Follow Up ◽  
Immunoglobulin Replacement ◽  
Common Variable

scholarly journals Rituximab Associated Hypogammaglobulinemia in Autoimmune Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Joanna Tieu ◽  
Rona M. Smith ◽  
Seerapani Gopaluni ◽  
Dinakantha S. Kumararatne ◽  
Mark McClure ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Replacement Therapy ◽  
Lupus Erythematosus ◽  
Severe Infection ◽  
Infection Rates ◽  
Immunoglobulin Replacement Therapy ◽  
Long Term Follow Up ◽  
Immunoglobulin Replacement

ObjectiveTo evaluate the characteristics of patients with autoimmune disease with hypogammaglobulinemia following rituximab (RTX) and describe their long-term outcomes, including those who commenced immunoglobulin replacement therapy.MethodsPatients received RTX for autoimmune disease between 2003 and 2012 with immunoglobulin G (IgG) <7g/L were included in this retrospective series. Hypogammaglobulinemia was classified by nadir IgG subgroups of 5 to <7g/L (mild), 3 to <5g/L (moderate) and <3g/L (severe). Characteristics of patients were compared across subgroups and examined for factors associated with greater likelihood of long term hypogammaglobulinemia or immunoglobulin replacement.Results142 patients were included; 101 (71%) had anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV), 18 (13%) systemic lupus erythematosus (SLE) and 23 (16%) other conditions. Mean follow-up was 97.2 months from first RTX. Hypogammaglobulinemia continued to be identified during long-term follow-up. Median time to IgG <5g/L was 22.5 months. Greater likelihood of moderate hypogammaglobulinemia (IgG <5g/L) and/or use of immunoglobulin replacement therapy at 60 months was observed in patients with prior cyclophosphamide exposure (odds ratio (OR) 3.60 [95% confidence interval (CI) 1.03 – 12.53], glucocorticoid use at 12 months [OR 7.48 (95% CI 1.28 – 43.55], lower nadir IgG within 12 months of RTX commencement [OR 0.68 (95% CI 0.51 – 0.90)] and female sex [OR 8.57 (95% CI 2.07 – 35.43)]. Immunoglobulin replacement was commenced in 29/142 (20%) and associated with reduction in infection rates, but not severe infection rates.ConclusionHypogammaglobulinemia continues to occur in long-term follow-up post-RTX. In patients with recurrent infections, immunoglobulin replacement reduced rates of non-severe infections.

scholarly journals 597 Long Term Follow-up of Patients with Common Variable Immunodeficiency (Cvid) in Rio De Janeiro, Brazil

2012 ◽  
Vol 5 ◽  
pp. S189
Author(s):  
Amanda Seba ◽  
Norma de Paula Motta Rubini ◽  
Albertina Varandas Capelo ◽  
Eliane Miranda da Silva ◽  
Marilza Campos de Magalhães ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Rio De Janeiro ◽  
Long Term Follow Up ◽  
Common Variable

Long-Term Follow-Up on Affinity Maturation and Memory B-Cell Generation in Patients with Common Variable Immunodeficiency

2013 ◽  
Vol 33 (6) ◽  
pp. 1067-1077 ◽  
Author(s):  
V. Ballegaard ◽  
H. Permin ◽  
T. L. Katzenstein ◽  
H. V. Marquart ◽  
L. Schejbel
Keyword(s):  
B Cell ◽  
Common Variable Immunodeficiency ◽  
Affinity Maturation ◽  
Cell Generation ◽  
Memory B Cell ◽  
Long Term Follow Up ◽  
Common Variable

Long-Term Follow-Up and Outcome of a Large Cohort of Patients with Common Variable Immunodeficiency

2007 ◽  
Vol 27 (3) ◽  
pp. 308-316 ◽  
Author(s):  
ISABELLA QUINTI ◽  
ANNAROSA SORESINA ◽  
GIUSEPPE SPADARO ◽  
SILVANA MARTINO ◽  
SIMONA DONNANNO ◽  
...  
Keyword(s):  
Common Variable Immunodeficiency ◽  
Large Cohort ◽  
Long Term Follow Up ◽  
Common Variable
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