Post mortem changes in adenylate cyclase activity in rat brain striatum

1979 ◽  
Vol 35 (11) ◽  
pp. 1421-1422 ◽  
Author(s):  
P. Witte ◽  
H. Matthaei

1993 ◽  
Vol 629 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Brian Ross ◽  
Deborah Dawson ◽  
Deborah Dewar ◽  
Mhairi Macrae ◽  
John Knowler ◽  
...  








1977 ◽  
Vol 166 (3) ◽  
pp. 473-483 ◽  
Author(s):  
S Brydon-Golz ◽  
H Ohanian ◽  
A Bennun

At constant 1 mM-ATP, the Mg2+-saturation curves for adenylate cyclase (EC 4.6.1.1) particulate preparations obtained from corpus striatum and cortex tissues of rat brain show that addition of 0.1 mM-noradrenaline increases the apparent Vmax. for Mg2+ by 300% in corpus striatum particles, and by 280% in cortex particles. At 10 mM-MgCl2, the addition of 0.1 mM-noradrenaline increased by 800% the adenylate cyclase activity of corpus striatum particles. At all Mg2+ concentrations, the addition of 0.3 mM-CaCl2 suppressed the noradrenaline-induced stimulation of adenylate cyclase of corpus striatum particles, and even resulted in a strong inhibition of the activating effect of Mg2+ itself on adenylate cyclase of corpus striatum particles, and even resulted in a strong inhibition of the activating effect of Mg2+ itself on adenylate cyclase activity of cortex particles. The addition of noradrenaline during a 3 h preincubation of particle preparations of brain cortex at 38 degrees C decreased by more than 4-fold the half-life of the decay of adenylate cyclase activity. The addition of MgATP protected against noradrenaline-induced inactivation.





1988 ◽  
Vol 154 (2) ◽  
pp. 169-178 ◽  
Author(s):  
Anton N.M. Schoffelmeer ◽  
Kenner C. Rice ◽  
Arthur E. Jacobson ◽  
Johannus G. Van Gelderen ◽  
François Hogenboom ◽  
...  


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