Increased plasma corticosterone levels in bovine growth hormone (bGH) transgenic mice: Effects of ACTH, GH and IGF-I onin vitro adrenal corticosterone production

1996 ◽  
Vol 5 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Marcelo Cecim ◽  
Maria Alvarez-Sanz ◽  
Louis van de Kar ◽  
Sterling Milton ◽  
Andrzej Bartke
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Plasma Corticosterone ◽  
Bovine Growth Hormone ◽  
Igf I ◽  
Adrenal Corticosterone

Pharmacokinetics of radioiodinated human and ovine growth hormones in transgenic mice expressing bovine growth hormone

1993 ◽  
Vol 2 (4) ◽  
pp. 219-226 ◽  
Author(s):  
D. Turyn ◽  
A. Bartke
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Growth Hormones ◽  
Bovine Growth Hormone

Echocardiographic evaluation of cardiac function in transgenic mice over-expressing the bovine growth hormone gene

1999 ◽  
Vol 9 ◽  
pp. 156
Author(s):  
M. Bohlooly-Y ◽  
E. Bollano ◽  
J. Törnell ◽  
E. Omerovic ◽  
V. Kujacic ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Cardiac Function ◽  
Bovine Growth Hormone ◽  
Growth Hormone Gene ◽  
Echocardiographic Evaluation

Ethanol and nicotine consumption and preference in transgenic mice overexpressing the bovine growth hormone gene

1995 ◽  
Vol 50 (4) ◽  
pp. 563-570 ◽  
Author(s):  
Andrzej Bartke ◽  
Jimmy L. Vandergriff ◽  
Robert A. Jensen ◽  
Charles J. Meliska
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Bovine Growth Hormone ◽  
Growth Hormone Gene ◽  
Nicotine Consumption

Effects of bovine growth hormone (GH) expression in transgenic mice on serum and pituitary immunoreactive mouse GH levels and pituitary GH-releasing factor binding sites

1993 ◽  
Vol 129 (5) ◽  
pp. 446-452 ◽  
Author(s):  
AI Sotelo ◽  
A Bartke ◽  
D Turyn
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Binding Sites ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Serum Levels ◽  
Bovine Growth Hormone ◽  
Complete Suppression ◽  
Over Expression ◽  
Pituitary Glands ◽  
Scatchard Plots

Pituitary and serum levels of homologous growth hormone (GH) and characteristics of specific GH-releasing factor (GHRF) binding to pituitary homogenates were examined in transgenic mice expressing bovine GH (bGH) gene regulated by different promoters [mouse metallothionein-I (MT) or phosphoenolpyruvate carboxykinase (PEPCK)] and in their normal littermates. Pituitary GH concentration and GHRF binding were reduced by approximately 50% in transgenic MT-bGH mice in which serum bGH levels were about 20 μg/l and by approximately 95% in transgenic PEPCK-bGH mice in which serum bGH levels were tenfold higher. Suppression of plasma immunoreactive mouse GH (mGH) levels was detected in MT-bGH but not in PEPCK-bGH animals, presumably due to cross-reaction of the antiserum employed with bGH. Scatchard plots of GHRF binding to washed homogenates of pituitary glands from normal and young adult MT-bGH transgenic mice were curvilinear, indicating the presence of two types of binding sites, with low and high affinities. Both types of binding sites were reduced in number in MT-bGH transgenic mice without changes in their affinity. In 5–7-month-old MT-bGH transgenic mice there were changes in pituitary GH levels, in GHRF binding levels and in characteristics of GHRF binding that closely resembled the alterations described previously in aging rats. We conclude that over-expression of heterologous GH genes in transgenic mice can lead to partial or virtually complete suppression of somatotroph function, depending on the levels of heterologous GH in the circulation, and that transgenic MT-bGH mice exhibit symptoms of remarkably early onset of neuroendocrine aging.

scholarly journals Conversion of bovine growth hormone cysteine residues to serine affects secretion by cultured cells and growth rates in transgenic mice.

1992 ◽  
Vol 6 (4) ◽  
pp. 598-606
Author(s):  
X Z Chen ◽  
A W Shafer ◽  
J S Yun ◽  
Y S Li ◽  
T E Wagner ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Growth Rates ◽  
Cultured Cells ◽  
Cysteine Residues ◽  
Bovine Growth Hormone

scholarly journals Myocardial hypertrophy in transgenic mice overexpressing the bovine growth hormone (bGH) gene

2000 ◽  
Vol 247 (5) ◽  
pp. 546-552 ◽  
Author(s):  
M. L. X. Fu ◽  
J. Tornell ◽  
W. Schulze ◽  
J. Hoebeke ◽  
O. G. P. Isaksson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Myocardial Hypertrophy ◽  
Bovine Growth Hormone

Down regulation of masked and unmasked insulin receptors in the liver of transgenic mice expressing bovine growth hormone gene

Life Sciences ◽  
1992 ◽  
Vol 51 (10) ◽  
pp. 771-778 ◽  
Author(s):  
A. Balbis ◽  
J.M. Dellacha ◽  
R.S. Calandra ◽  
A. Bartke ◽  
D. Turyn
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Insulin Receptors ◽  
Bovine Growth Hormone ◽  
Growth Hormone Gene ◽  
Down Regulation

Rabbit whey acidic protein gene upstream region controls high-level expression of bovine growth hormone in the mammary gland of transgenic mice

1995 ◽  
Vol 42 (3) ◽  
pp. 261-267 ◽  
Author(s):  
Dominique Thépot ◽  
Eve Devinoy ◽  
Marie-Louise Fontaine ◽  
Marie-Georges Stinnakre ◽  
Micheline Massoud ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Mammary Gland ◽  
Transgenic Mice ◽  
Protein Gene ◽  
Whey Acidic Protein ◽  
Acidic Protein ◽  
Upstream Region ◽  
Bovine Growth Hormone ◽  
High Level Expression ◽  
High Level
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