There is paucity of information about the prevalence of hematological disorders in Yemen and neighboring countries
.This is the rst project to evaluate the relative spectrum of hematological diseases in Taiz and Ibb governorate Yemen
,by method of bone marrow examination which is considered an important valuable diagnostic tool, for evaluation and nal diagnosis of various
hematological and non-hematological disorders especially when CBC and peripheral blood lm study and other investigation failed to give a
diagnosis .
OBJECTIVES: The aim of this study was to evaluate the spectrum of haematological diseases diagnosed by bone marrow examination in Taiz
and IBB governorates Yemen between September 2016 and October 2020 .Patients and method : A total of 1108 patients aged between
(1 -100 )years old were evaluated by bone marrow examination at referral hematological center in IBB city Yemen . Relevant investigations
were performed when needed. After exclusion of 98 patients with normal bone marrow ndings ,a total of 1010 patients had hematological
disorders , and their data were analyzed. There were 527 (52.2 %) males and 483(47.8 %) females . A total of 655(64.9%) patients had benign
hematological diseases and 355 (35.1% ) patients had malignant hematological diseases .
RESULTS :A total of 138 patients had Iron deciency anemia ,107 had immune thrombocytopenic purpura (ITP) , 92 had hypersplenism,84
had Acute lymphoblastic leukemia ,79 had Acute myeloid leukaemia, 71 had megaloblastic anemia 58 had myeloproliferative disorder , 53 had
Chronic myeloid leukemia , 45 had hemolytic anemia ,45had visceral leishmaniasis. 44 had malaria, 38 had chronic lymphocytic leukemia 38
had anemia of chronic disease ,25 had aplastic anemia ,25 had myelodysplastic syndromes, ,21 had anemia of infection ,19 had congenital
syndroms,7had multiple myeloma ,6 had mixed deciency anemia and 5 had metastatic deposits , 4 had myeloid leukomoid reaction ,4 had
lymphoma inltration and 2 had hairy cell leukemia . Sex- and age-related distribution of the various disorders was also presented.
CONCLUSION: The anemias of all types were the most frequently encountered diagnosis followed by acute and chronic leukemias , ITP ,
Hypersplenism , ,myeloproliferative disorder , visceral leishmaniasis , malaria, myelodysplastic syndrome and congenital syndromes
respectively. The other haematological disorders were less common. These ndings are comparable with published data in previous studies
done in Yemen and other developing countries
Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment
