Stable microbubble test for predicting the risk of respiratory distress syndrome: II. Prospective evaluation of the test on amniotic fluid and gastric aspirate

1993 ◽  
Vol 152 (2) ◽  
pp. 152-156 ◽  
Author(s):  
S. Chida ◽  
T. Fujiwara ◽  
M. Konishi ◽  
H. Takahashi ◽  
M. Sasaki
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Amniotic Fluid ◽  
Distress Syndrome ◽  
Gastric Aspirate ◽  
Prospective Evaluation ◽  
Stable Microbubble Test

PREDICTION OF RESPIRATORY- DISTRESS SYNDROME BY ESTIMATION OF SURFACTANT IN THE AMNIOTIC FLUID

The Lancet ◽  
1973 ◽  
Vol 301 (7818) ◽  
pp. 1475-1477 ◽  
Author(s):  
C.J Dewhurst ◽  
AngelaM Dunham ◽  
D.R Harvey ◽  
ChristineE Parkinson
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Amniotic Fluid ◽  
Distress Syndrome

Questions for Bauer et al.

PEDIATRICS ◽  
1974 ◽  
Vol 54 (4) ◽  
pp. 518-518
Author(s):  
Stuart Shelton Stevenson
Keyword(s):  
Guinea Pig ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Amniotic Fluid ◽  
Human Disease ◽  
Recent Article ◽  
Distress Syndrome ◽  
Hyaline Membrane

The recent article by Bauer et al., which associates prolonged rupture of membranes with a decreased incidence of respiratory distress syndrome, is intriguing.1 Stevenson and Laufe theorized, on the basis of guinea pig experiments,2-4 that "... the human disease occurred when aspirated amniotic fluid reacted with pulmonary exudate in the lungs and the resulting film of fibrin coated the alveoli and alveolar ducts in the form of a hyaline membrane." The infants cited in Bauer's article obviously had less opportunity to aspirate amniotic fluid and their elevated corticosteroid levels might have mitigated the severity of their pulmonary exudates.

Assay of disaturated phosphatidylcholine in amniotic fluid as a test of fetal lung maturity: experience with 2000 analyses.

1987 ◽  
Vol 33 (9) ◽  
pp. 1648-1651 ◽  
Author(s):  
M Y Tsai ◽  
E K Shultz ◽  
P P Williams ◽  
R Bendel ◽  
J Butler ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Amniotic Fluid ◽  
Distress Syndrome ◽  
Fetal Lung ◽  
Fetal Lung Maturity ◽  
Pooled Samples ◽  
Lung Maturity ◽  
Diabetic Mothers ◽  
Length Of Gestation

Abstract We determined concentrations of disaturated phosphatidylcholine (DSPC) in nearly 2000 amniotic fluid samples obtained either transabdominally or as vaginal pools. Here we report our comparison of these DSPC values with the lecithin/sphingomyelin (L/S) ratios for amniotic fluid samples obtained from diabetic and nondiabetic pregnancies and also between transabdominally or vaginally collected samples uncontaminated by blood or meconium. DSPC measurement is at least as good as the L/S ratio in predicting the absence of respiratory distress syndrome. DSPC concentrations were, however, lower in diabetic than in nondiabetic pregnancies, supporting the hypothesis that DSPC synthesis may be impaired in fetuses of diabetic mothers. Visually uncontaminated samples collected transabdominally or vaginally, when grouped according to length of gestation, have similar DSPC values but different L/S ratios. Thus, even in the absence of blood or meconium, DSPC may be a more useful test than the L/S ratio for vaginally pooled samples.

Detection frequency by thin-layer chromatography of phosphatidylglycerol in amniotic fluid with clinically functional pulmonary surfactant.

1988 ◽  
Vol 34 (10) ◽  
pp. 1976-1982 ◽  
Author(s):  
T Spillman ◽  
D B Cotton ◽  
E Golunski
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Thin Layer ◽  
Amniotic Fluid ◽  
Pulmonary Surfactant ◽  
Distress Syndrome ◽  
Total Group ◽  
Respiratory Problems ◽  
Detection Frequency ◽  
Layer Chromatography

Abstract Densitometric lecithin/sphingomyelin ratios (LSR) and the presence of phosphatidylglycerol (PG) were determined for 735 consecutively received amniotic fluids. Of the 371 fluids with "mature" LSR between 2.0 and 4.5, more than one-third lacked detectable PG. Clinical outcomes for the 305 of the total group that were delivered within 72 h of sampling were also determined. Respiratory distress syndrome (RDS) did not occur in the 239 cases with LSR greater than or equal to 2.0, even when, as in 43 instances, PG was not detected. When the LSR was greater than or equal to 2.0, transient tachypnea was more prevalent in the absence of detectable PG (PG detected, 3% transient tachypnea; PG undetected, 16% transient tachypnea). Of the 103 cases where PG was undetected, 58% exhibited no respiratory problems. Even in the 60 cases where the LSR was less than 2.0 and PG was not detected, 42% of the cases were free of respiratory problems. RDS did not occur in any case where PG was detected, even in the six where the LSR was less than 2.0. We evaluate these results in light of various contradictory reports in the literature.

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