Detection of chromosomal abnormalities in human preimplantation embryos using FISH

1996 ◽  
Vol 13 (2) ◽  
pp. 137-139 ◽  
Author(s):  
Joyce C. Harper ◽  
Joy D. A. Delhanty
Keyword(s):  
Chromosomal Abnormalities ◽  
Preimplantation Embryos ◽  
Human Preimplantation Embryos

Cytogenetic analysis of human preimplantation embryos following developmental arrest in vitro

1998 ◽  
Vol 10 (6) ◽  
pp. 505 ◽  
Author(s):  
Paula A. Almeida ◽  
Virginia N. Bolton
Keyword(s):  
Chromosomal Abnormality ◽  
Cytogenetic Analysis ◽  
Chromosomal Abnormalities ◽  
Preimplantation Embryo ◽  
Preimplantation Embryos ◽  
Cell Stage ◽  
Developmental Arrest ◽  
The Relationship ◽  
Human Preimplantation Embryos

The relationship between chromosomal abnormalities in the human preimplantation embryo and developmental arrest in vitro was investigated. Cytogenetic analysis of 171 embryos that had arrested between the pronucleate and the 8-cell stages demonstrated that the overall incidence of chromosomal abnormality among these embryos was 63.4%. Of the embryos that arrested at the pronucleate stage (n = 48), 47.9% were chromosomally abnormal, compared with 59.5% of those that arrested between the 2- and 4-cell stages (n = 50), and 82.8% of those arrested between the 5- and 8-cell stage (n = 73). The rate of abnormality in embryos with poor morphology (irregular shaped blastomeres and considerable extracellular fragmentation) was significantly higher (86.8%; n = 33) than those with good morphology (60%; n = 51; P<0.005). These results suggest that there is an association between chromosomal abnormality, developmental arrest in vitro, and poor morphology.

Chromosome Breakage in Human Preimplantation Embryos from Carriers of Structural Chromosomal Abnormalities in Relation to Fragile Sites, Maternal Age, and Poor Sperm Factors

2012 ◽  
Vol 136 (1) ◽  
pp. 21-29 ◽  
Author(s):  
L. Xanthopoulou ◽  
H. Ghevaria ◽  
A. Mantzouratou ◽  
P. Serhal ◽  
A. Doshi ◽  
...  
Keyword(s):  
Maternal Age ◽  
Chromosomal Abnormalities ◽  
Chromosome Breakage ◽  
Fragile Sites ◽  
Preimplantation Embryos ◽  
Human Preimplantation Embryos

Self-Correction of Chromosomal Abnormalities in Human Preimplantation Embryos and Embryonic Stem Cells

2013 ◽  
Vol 22 (17) ◽  
pp. 2449-2456 ◽  
Author(s):  
Masood Bazrgar ◽  
Hamid Gourabi ◽  
Mojtaba Rezazadeh Valojerdi ◽  
Poopak Eftekhari Yazdi ◽  
Hossein Baharvand
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Chromosomal Abnormalities ◽  
Embryonic Stem ◽  
Preimplantation Embryos ◽  
Human Preimplantation Embryos

scholarly journals Transmission ratio distortion in the myotonic dystrophy locus in human preimplantation embryos

2006 ◽  
Vol 14 (3) ◽  
pp. 299-306 ◽  
Author(s):  
Nicola L Dean ◽  
J Concepción Loredo-Osti ◽  
T Mary Fujiwara ◽  
Kenneth Morgan ◽  
Seang Lin Tan ◽  
...  
Keyword(s):  
Myotonic Dystrophy ◽  
Transmission Ratio Distortion ◽  
Preimplantation Embryos ◽  
Transmission Ratio ◽  
Ratio Distortion ◽  
Human Preimplantation Embryos

Improvement of the culture conditions for the development of human preimplantation embryos

1990 ◽  
Vol 5 (2) ◽  
pp. 217-220 ◽  
Author(s):  
A.L. Muggleton-Harris ◽  
I. Findlay ◽  
D.G. Whittingham
Keyword(s):  
Culture Conditions ◽  
Preimplantation Embryos ◽  
Human Preimplantation Embryos

scholarly journals P59 Over-expression of ATR and XRCC1 as potential biomarkers for poor prognosis in human preimplantation embryos

2012 ◽  
Vol 24 ◽  
pp. S71
Author(s):  
M. Bazrgar ◽  
H. Gourabi ◽  
P. Eftekhari-Yazdi ◽  
H. Vaziri ◽  
M. Fakhri ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Preimplantation Embryos ◽  
Over Expression ◽  
Human Preimplantation Embryos ◽  
Potential Biomarkers

scholarly journals Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos

2021 ◽  
Vol 9 (2) ◽  
pp. 18
Author(s):  
Ioanna Bouba ◽  
Elissavet Hatzi ◽  
Paris Ladias ◽  
Prodromos Sakaloglou ◽  
Charilaos Kostoulas ◽  
...  
Keyword(s):  
Assisted Reproduction ◽  
Basic Research ◽  
Blastocyst Stage ◽  
Preimplantation Embryos ◽  
New Approach ◽  
Assisted Reproduction Technology ◽  
Clinical Utilization ◽  
Art Practices ◽  
In Utero Development ◽  
Human Preimplantation Embryos

Applications and indications of assisted reproduction technology are expanding, but every new approach is under scrutiny and thorough consideration. Recently, groups of assisted reproduction experts have presented data that support the clinical use of mosaic preimplantation embryos at the blastocyst stage, previously excluded from transfer. In the light of published contemporary studies, with or without clinical outcomes, there is growing evidence that mosaic embryos have the capacity for further in utero development and live birth. Our in-depth discussion will enable readers to better comprehend current developments. This expansion into the spectrum of ART practices requires further evidence and further theoretical documentation, basic research, and ethical support. Therefore, if strict criteria for selecting competent mosaic preimplantation embryos for further transfer, implantation, fetal growth, and healthy birth are applied, fewer embryos will be excluded, and more live births will be achieved. Our review aims to discuss the recent literature on the transfer of mosaic preimplantation embryos. It also highlights controversies as far as the clinical utilization of preimplantation embryos concerns. Finally, it provides the appropriate background to elucidate and highlight cellular and genetic aspects of this novel direction.

scholarly journals Quantitative and qualitative changes of mitochondria in human preimplantation embryos

2017 ◽  
Vol 34 (5) ◽  
pp. 573-580 ◽  
Author(s):  
Shu Hashimoto ◽  
Naoharu Morimoto ◽  
Masaya Yamanaka ◽  
Hiroshi Matsumoto ◽  
Takayuki Yamochi ◽  
...  
Keyword(s):  
Preimplantation Embryos ◽  
Human Preimplantation Embryos ◽  
Qualitative Changes

scholarly journals Effects of pyruvate and glucose on the development of human preimplantation embryos in vitro

Reproduction ◽  
1993 ◽  
Vol 99 (1) ◽  
pp. 87-95 ◽  
Author(s):  
J. Conaghan ◽  
A. H. Handyside ◽  
R. M. L. Winston ◽  
H. J. Leese
Keyword(s):  
Preimplantation Embryos ◽  
Human Preimplantation Embryos
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