Response variability of human brain tumors to AZQ in tissue culture

1986 ◽  
Vol 4 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Paul L Kornblith ◽  
Louis Rosa ◽  
James D Bona ◽  
John A Edwards ◽  
Nancy Matuzic ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Brain Tumors ◽  
Human Brain ◽  
Response Variability ◽  
Human Brain Tumors

scholarly journals Selective Lutheran Glycoprotein Gene Expression at the Blood—Brain Barrier in Normal Brain and in Human Brain Tumors

2000 ◽  
Vol 20 (7) ◽  
pp. 1096-1102 ◽  
Author(s):  
Ruben J. Boado ◽  
Jian Yi Li ◽  
William M. Pardridge
Keyword(s):  
Gene Expression ◽  
Tissue Culture ◽  
Brain Tumors ◽  
Human Brain ◽  
Northern Blot Analysis ◽  
Bovine Brain ◽  
Capillary Endothelium ◽  
Brain Capillary ◽  
Human Brain Tumors ◽  
High Level

The Lutheran (LU) glycoprotein was shown to be a specific marker of brain capillary endothelium, which forms the blood-brain barrier (BBB) in vivo. A 1.5 kb partial cDNA encoding the bovine LU was isolated from a bovine brain capillary cDNA library. Sequence analysis showed that the bovine and human LU had a 75% and 79% identity in the amino acid and nucleotide sequences, respectively. Northern blot analysis demonstrated a very high level of gene expression of the LU transcript in freshly isolated bovine brain capillaries, but no measurable LU mRNA in whole bovine brain. The high level of LU gene expression was maintained when bovine brain capillary endothelium was grown in tissue culture. Because many BBB specific genes are downregulated in tissue culture and in brain tumors, the expression of the LU mRNA and immunoactive LU protein was investigated in primary and metastatic human brain tumors. Immunocytochemistry of fresh frozen human brain and human brain tumors showed abundant immunostaining of brain capillary endothelium. Northern blot analysis showed the presence of LU transcripts in a panel of primary and metastatic human brain tumors. These studies demonstrated that the LU glycoprotein was a novel new marker of the BBB, and unlike other BBB specific genes, there was a persistent gene expression of the LU glycoprotein both in brain capillary endothelial cells grown in culture and in the endothelium of capillaries perfusing human brain cancer.

scholarly journals Human Brain Tumors and Simian Virus 40

1995 ◽  
Vol 87 (17) ◽  
pp. 1331-1331 ◽  
Author(s):  
F. MARTINI ◽  
M. D. MATTEI ◽  
L. IACCHERI ◽  
L. LAZZARIN ◽  
G. BARBANTI-BRODANO ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
Human Brain Tumors

Neurogenetics and the molecular biology of human brain tumors

Brain Tumors ◽  
2012 ◽  
pp. 83-101
Author(s):  
Ivan Radovanovic ◽  
Abhijit Guha
Keyword(s):  
Molecular Biology ◽  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

Sterols in cerebrospinal fluid during nitrosourea chemotherapy of human brain tumors

1976 ◽  
Vol 8 (2) ◽  
pp. 127-141 ◽  
Author(s):  
Remo Fumagalli ◽  
Stefano Pezzotta ◽  
Anna R. Racca ◽  
Pietro Paoletti
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

Magnetic Field Dependence of 1/T1of Human Brain Tumors

1990 ◽  
Vol 25 (11) ◽  
pp. 1197-1205 ◽  
Author(s):  
N LUNDBOM ◽  
R D BROWN ◽  
S H KOENIG ◽  
T A LANSEN ◽  
M P VALSAMIS ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Brain Tumors ◽  
Human Brain ◽  
Field Dependence ◽  
Magnetic Field Dependence ◽  
Human Brain Tumors

Ultrastructure of concentric laminations in primary human brain tumors

1986 ◽  
Vol 71 (1-2) ◽  
pp. 83-87 ◽  
Author(s):  
H. Kamitani ◽  
H. Masuzawa ◽  
J. Sato ◽  
M. Okada
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

The expression of Galβ1,4GlcNAc α2,6 sialyltransferase and α2,6-linked sialoglycoconjugates in human brain tumors

1996 ◽  
Vol 91 (3) ◽  
pp. 284-292 ◽  
Author(s):  
Yoichi Kaneko ◽  
Hirotaka Yamamoto ◽  
Donna S. Kersey ◽  
Karen J. Colley ◽  
J. E. Leestma ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

Rac2 expression and mutation in human brain tumors

2005 ◽  
Vol 147 (5) ◽  
pp. 551-554 ◽  
Author(s):  
S.-L. Hwang ◽  
A.-S. Lieu ◽  
J.-H. Chang ◽  
T.-S. Cheng ◽  
C.-Y. Cheng ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors
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