Laboratory investigations Development of the connective tissue of the extraocular muscles and clinical significance

1988 ◽  
Vol 226 (3) ◽  
pp. 246-251 ◽  
Author(s):  
David Sevel
Keyword(s):  
Connective Tissue ◽  
Clinical Significance ◽  
Extraocular Muscles ◽  
Laboratory Investigations

THE HEXOSAMINE CONTENT OF THE ORBIT IN RELATION TO ANTI-THYROTROPHIN ANTIBODY TITRES IN SERA OF THYROTROPHIN-TREATED RABBITS WITH AND WITHOUT CORTISONE ADMINISTRATION

1962 ◽  
Vol 41 (3) ◽  
pp. 474-480 ◽  
Author(s):  
Otto Wegelius ◽  
E. J. Jokinen
Keyword(s):  
Connective Tissue ◽  
Guinea Pigs ◽  
Antibody Formation ◽  
Direct Proof ◽  
Significant Rise ◽  
Extraocular Muscles ◽  
Concomitant Treatment ◽  
Antibody Titres ◽  
Hexosamine Content ◽  
Synergetic Action

ABSTRACT In all previous investigations on experimental exophthalmos, heterologous thyrotrophic pituitary extracts have been used. These protein hormones stimulate antihormone formation in the test animals. Cortisone has been reported to effectively block antibody formation. In addition, it has been shown to potentiate TSH-induced exophthalmos in guinea-pigs. With rabbits as test animals, the hexosamine content of the orbital tissues was determined and used as an index of exophthalmos development and at the same time the antibody titres in the sera were followed. TSH injections for six weeks led to a highly significant accumulation of hexosamine in the retrobulbar connective tissue and in the extraocular muscles, i. e. an increase of up to 400% as compared with the control animals. At the same time a significant rise in antihormonal titres was detectable in the sera. Concomitant treatment with cortisone brought about an equal or higher accumulation of hexosamine but significantly lower antibody titres. The known opposite peripheral actions of TSH and cortisone can be reconciled with the synergy in producing experimental exophthalmos by attributing the synergetic action of cortisone to the blocking of antihormone formation. If less antihormones are produced, the effect of TSH is enhanced. Our experiments do not provide direct proof for this hypothesis. High hexosamine values in the orbit and low antihormone titres in the serum are, however, concomitant phenomena.

Tympanosclerosis: Clinical Implications of the Theory of Pathogenesis

1983 ◽  
Vol 92 (6) ◽  
pp. 635-639 ◽  
Author(s):  
Maurice Schiff
Keyword(s):  
General Practitioner ◽  
Connective Tissue ◽  
Clinical Significance ◽  
Family Physician ◽  
Disease Process ◽  
Clinical Implications ◽  
Developmental Patterns ◽  
Preventable Disease ◽  
Causative Factors

Tympanosclerosis is a preventable disease. Its elimination is more the responsibility of the pediatrician and general practitioner than the otolaryngologist's. The education of our colleagues is the most effective way of possibly eliminating this disease process. Cholesteatoma and tympanosclerosis may have similar causative factors, but certainly have different pathogenic developmental patterns; their occurrence together in otologic disease is coincidental. The mechanism of this disease process shows that the subepidermal and submucosal connective tissue layers of the eardrum are the ones involved. The cure for tympanosclerosis may be achieved more easily than its amelioration. This may seem like a strange paradox, but cure is intimately bound up with prevention which is the key for the clinical significance of this theory of pathogenesis. The pediatrician and the general practitioner, or family physician — the first to see the children with their ear problems — are urged to refer patients to an otologist when fluid is turbid. Development of tympanosclerosis must be prevented in the early but treatable stages. Prevention is less costly than repair.

P1182Asymptomatic masses on the pacing leads - influence on long term survival

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Polewczyk ◽  
D Nowosielecka ◽  
A Tomaszewski ◽  
W Brzozowski ◽  
D Szczesniak-Stanczyk ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Clinical Significance ◽  
Electronic Devices ◽  
Single Center ◽  
Term Survival ◽  
Long Term Survival ◽  
Cardiac Implantable Electronic Devices ◽  
Pacing Leads

Abstract Background Asymptomatic Masses on Endocardiac Leads  (AMELs) are relatively often found in echocardiography in patients with cardiac implantable electronic devices (CIED) but their clinical significance is unknown. Purpose Aim of the study was to evaluate the incidence of AMELs and assesment of their influence on long term survival (mean follow up- 4,28 ± 3,13 years) of patients undergoing transvenous leads extraction (TLE). Methods We analyzed the clinical data of patients undergoing TLE in single center in years 2006-2019. Echocardiography before TLE was performed in 2558  patients (60,4% male). AMELs were detected in 426 (16,7%) cases. Classifications of AMELs included connective tissue surronding the leads, clots, alike vegetations masses.  Additionally, real vegetations, thickening of the leads and strong connective tissue scars were distinguished. Long term survival was compared between individual types of AMELs and patients without any additional masses on the leads. Results are presented in the table. Conclusion Poor long-term survival was observed in patients with AMELs on the pacing leads. Abstract Table

scholarly journals Understanding the extraocular muscles: connective tissue, motor endplates and the cytoskeleton

2020 ◽  
Vol 42 (5) ◽  
pp. 52-57
Author(s):  
Jing-Xia Liu ◽  
Nils Dennhag ◽  
Fatima Pedrosa Domellöf
Keyword(s):  
Visual Acuity ◽  
Connective Tissue ◽  
Coping Strategies ◽  
Skeletal Muscles ◽  
Premature Death ◽  
Extraocular Muscles ◽  
The Body ◽  
Motor Endplates ◽  
Severe Handicap ◽  
Future Treatment

We constantly direct our eyes to the object of interest with the help of the extraocular muscles, and thereby use foveal fixation to attain the best possible visual acuity. The muscles around the eye are rather different from other skeletal muscles, being, for example, simultaneously the fastest muscles in the body and impossible to exhaust. The most exciting property of the extraocular muscles is their unique response to disease, as they often remain unaffected in muscle conditions which lead to severe handicap and premature death. Understanding the coping strategies that allow the extraocular muscles to remain unaffected may provide clues for the future treatment of severe diseases such as muscle dystrophies.

E077 Clinical significance of gaining additional specific autoantibodies during follow-up in connective tissue disease

Rheumatology ◽  
2019 ◽  
Vol 58 (Supplement_3) ◽  
Author(s):  
Kristina E N Clark ◽  
Corrado Campochiaro ◽  
Lauren V Host ◽  
Jennifer Harvey ◽  
Christopher P Denton ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Clinical Significance ◽  
Connective Tissue Disease
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