Acute and chronic ethanol tolerance: operant behaviour in naive and ethanol tolerant rats

1992 ◽  
Vol 107 (4) ◽  
pp. 511-516 ◽  
Author(s):  
Arto J. Hiltunen ◽  
Torbjörn U. C. Järbe
Keyword(s):  
Ethanol Tolerance ◽  
Chronic Ethanol ◽  
Operant Behaviour

Chronic ethanol tolerance through free-choice drinking in the P line of alcohol-preferring rats

1987 ◽  
Vol 28 (1) ◽  
pp. 111-115 ◽  
Author(s):  
G.J. Gatto ◽  
J.M. Murphy ◽  
M.B. Waller ◽  
W.J. McBride ◽  
L. Lumeng ◽  
...  
Keyword(s):  
Free Choice ◽  
Ethanol Tolerance ◽  
Chronic Ethanol

Chronic Alcoholism Decreases Polyunsaturated Fatty Acid Levels in Human Plasma, Erythrocytes, and Platelets – Influence of Chronic Liver Disease

1997 ◽  
Vol 78 (02) ◽  
pp. 808-812 ◽  
Author(s):  
María-Luisa Pita ◽  
José-María Rubio ◽  
María-Luisa Murillo ◽  
Olimpia Carreras ◽  
Mariá-José Delgado
Keyword(s):  
Fatty Acid ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Alcoholism ◽  
Chronic Liver ◽  
Chronic Ethanol ◽  
Ethanol Ingestion ◽  
Control Group ◽  
Docosatetraenoic Acid ◽  
Long Chain

SummaryThe effect of chronic ethanol ingestion on fatty acid composition of plasma, erythrocyte and platelet phospholipids and on plasma 6-keto-PGF1α was studied. Two groups of alcoholic subjects, one of them with chronic liver disease, were studied and compared to a control group of healthy subjects. Linoleic acid was not affected by alcoholism but its larger metabolites arachidonic acid (20:4n6) and docosatetraenoic acid (22: 4n6) tended to be lower in erythrocytes and platelets of both groups of alcoholic patients; the decrease was more marked in the presence of chronic liver disease. Docosahexaenoic acid (22:6n3) was markedly decreased in plasma, erythrocytes and platelets obtained from alcoholic patients with chronic liver disease. Plasma levels of 6-keto-PGF1α, a metabolite of prostacyclin (PGI2), remained unchanged. We conclude that chronic ethanol ingestion induces important changes in long-chain polyunsaturated fatty acids, mainly in platelets, and that these changes are exacerbated when patients suffer from chronic liver disease.

ULTRASTRUCTURAL REMODELING OF RAT SUBMANDIBULAR GLANDS IN CHRONIC ETHANOL INTOXICATION

2020 ◽  
Vol 16 (73) ◽  
pp. 175
Author(s):  
G.А. Yeroshenko ◽  
K.V. Shevchenko ◽  
O.D. Lisachenko ◽  
O.V. Vilhova ◽  
O.S. Yakushko ◽  
...  
Keyword(s):  
Chronic Ethanol ◽  
Ethanol Intoxication ◽  
Submandibular Glands ◽  
Chronic Ethanol Intoxication

Effects of Chronic Ethanol Abuse on Structure and Enzyme Activities of Skeletal Muscle in Man

1975 ◽  
Vol 35 (6) ◽  
pp. 601-607 ◽  
Author(s):  
K. -H. Kiessling ◽  
L. Pilström ◽  
A. -C. Bylund ◽  
K. Piehl ◽  
B. Saltin
Keyword(s):  
Skeletal Muscle ◽  
Enzyme Activities ◽  
Chronic Ethanol ◽  
Ethanol Abuse

scholarly journals Effect of chronic ethanol ingestion on fatty acid oxidation by hepatic mitochondria.

1975 ◽  
Vol 250 (13) ◽  
pp. 5122-5129
Author(s):  
A I Cederbaum ◽  
C S Lieber ◽  
D S Beattie ◽  
E Rubin
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Chronic Ethanol ◽  
Ethanol Ingestion ◽  
Acid Oxidation

Magnetic Resonance Imaging and Spectroscopy: New Noninvasive In Vivo Approaches in Toxicology Research

1993 ◽  
Vol 21 (4) ◽  
pp. 411-425
Author(s):  
Manfred Brauer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fatty Infiltration ◽  
Chronic Ethanol ◽  
Ethanol Administration ◽  
Resonance Imaging ◽  
Human Patient ◽  
Hypoxic Injury ◽  
Imaging And Spectroscopy

Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) give anatomical and biochemical information about a human patient or animal in a non-invasive manner. This unique quality permits the study of toxicological responses of an organ within an intact animal and in a manner in which many fewer animals are needed than by conventional methods of investigation. The use of MRI and MRS in the study of hepatotoxicants, particularly bromobenzene and ethanol, is reviewed. Bromobenzene causes localised hepatic oedema and bioenergetic deterioration; these changes were followed with time by 1H MRI and 31P MRS, respectively. Phosphocholine levels in the liver were found to increase dramatically during bromobenzene-induced damage, possibly related to an intracellular control mechanism in response to tissue damage. The ability of the bromobenzene-challenged liver to metabolise a fructose load was followed by dynamic 31P MRS. Chronic ethanol administration damages the liver. This toxicological process results in the accumulation of fat in the liver, which was followed by fat-selective 1H MRI. When ethanol is no longer administered to the subject, the fatty infiltration subsides, and this process was followed over 16 days in the same animal using fat-selective 1H MRI. Chronic ethanol renders the liver in situ more susceptible to hypoxic injury and less likely to recover afterwards, as shown by 31P MRS.

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