Effects of ZK 93426 on muscarinic and nicotinic antagonist or nucleus basalis lesioning-induced electrocortical slowing

1993 ◽  
Vol 111 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Paavo Riekkinen ◽  
Minna Riekkinen ◽  
Jouni Sirviö ◽  
Paavo Riekkinen
Keyword(s):  
Nucleus Basalis ◽  
Zk 93426

Acquisition, retention, and extinction of operant discriminations in rats with nucleus basalis magnocellularis lesions.

1995 ◽  
Vol 109 (4) ◽  
pp. 699-713 ◽  
Author(s):  
Allen E. Butt ◽  
Gordon K. Hodge
Keyword(s):  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis

Nucleus Basalis Magnocellularis Lesions Impair Acquisition but do Not Cause Perseveration in an Operant Discrimination

1999 ◽  
Author(s):  
Allen E. Butt ◽  
Timothy D. Bowman ◽  
J. Scott Novotney ◽  
Jason L. Rogers ◽  
Ruth A. Stoehr
Keyword(s):  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis ◽  
Operant Discrimination

scholarly journals In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies

2021 ◽  
Vol 30 ◽  
pp. 102604
Author(s):  
Julia Schumacher ◽  
John-Paul Taylor ◽  
Calum A. Hamilton ◽  
Michael Firbank ◽  
Ruth A. Cromarty ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Lewy Bodies ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

scholarly journals Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease

2021 ◽  
pp. 1-6
Author(s):  
Julia Schumacher ◽  
Alan J. Thomas ◽  
Luis R. Peraza ◽  
Michael Firbank ◽  
John T. O’Brien ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Lewy Body ◽  
Cholinergic System ◽  
Structural Changes ◽  
Lewy Body Dementia ◽  
Occipital Cortex ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

ABSTRACT Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.

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