Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure

1991 ◽  
Vol 104 (4) ◽  
pp. 515-521 ◽  
Author(s):  
J. D. Salamone ◽  
R. E. Steinpreis ◽  
L. D. McCullough ◽  
P. Smith ◽  
D. Grebel ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Food Consumption ◽  
Food Choice ◽  
Free Food ◽  
Dopamine Depletion ◽  
Novel Food ◽  
Choice Procedure ◽  
Lever Pressing

Nucleus accumbens dopamine release increases during instrumental lever pressing for food but not free food consumption

1994 ◽  
Vol 49 (1) ◽  
pp. 25-31 ◽  
Author(s):  
John D. Salamone ◽  
Michael S. Cousins ◽  
Louise D. McCullough ◽  
Debbie L. Carriero ◽  
Robert J. Berkowitz
Keyword(s):  
Nucleus Accumbens ◽  
Food Consumption ◽  
Dopamine Release ◽  
Free Food ◽  
Lever Pressing

scholarly journals Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex–nucleus accumbens pathway in mice

2018 ◽  
Vol 115 (21) ◽  
pp. E4890-E4899 ◽  
Author(s):  
Qiaoling Cui ◽  
Qian Li ◽  
Hongyan Geng ◽  
Lei Chen ◽  
Nancy Y. Ip ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Receptors ◽  
Cortical Neurons ◽  
Critical Role ◽  
D2 Receptor ◽  
Receptor Activation ◽  
Prelimbic Cortex ◽  
Dopamine Depletion ◽  
Dopaminergic Tone ◽  
Type Receptor

The ability to abandon old strategies and adopt new ones is essential for survival in a constantly changing environment. While previous studies suggest the importance of the prefrontal cortex and some subcortical areas in the generation of strategy-switching flexibility, the fine neural circuitry and receptor mechanisms involved are not fully understood. In this study, we showed that optogenetic excitation and inhibition of the prelimbic cortex–nucleus accumbens (NAc) pathway in the mouse respectively enhances and suppresses strategy-switching ability in a cross-modal spatial-egocentric task. This ability is dependent on an intact dopaminergic tone in the NAc, as local dopamine denervation impaired the performance of the animal in the switching of tasks. In addition, based on a brain-slice preparation obtained from Drd2-EGFP BAC transgenic mice, we demonstrated direct innervation of D2 receptor-expressing medium spiny neurons (D2-MSNs) in the NAc by prelimbic cortical neurons, which is under the regulation by presynaptic dopamine receptors. While presynaptic D1-type receptor activation enhances the glutamatergic transmission from the prelimbic cortex to D2-MSNs, D2-type receptor activation suppresses this synaptic connection. Furthermore, manipulation of this pathway by optogenetic activation or administration of a D1-type agonist or a D2-type antagonist could restore impaired task-switching flexibility in mice with local NAc dopamine depletion; this restoration is consistent with the effects of knocking down the expression of specific dopamine receptors in the pathway. Our results point to a critical role of a specific prelimbic cortex–NAc subpathway in mediating strategy abandoning, allowing the switching from one strategy to another in problem solving.

Gender effects on odor-induced taste enhancement and subsequent food consumption

2020 ◽  
Vol 37 (5) ◽  
pp. 511-519
Author(s):  
Yamen Koubaa ◽  
Amira Eleuch
Keyword(s):  
Food Consumption ◽  
Free Food ◽  
Gender Effects ◽  
Taste Perception ◽  
Personal Factors ◽  
Men And Women ◽  
Content Type ◽  
Gender Specific ◽  
Taste Enhancement ◽  
Detection And Recognition

Purpose The purpose of this paper is to test for gender-specific effects on odor-induced taste enhancement and subsequent food consumption in olfactory food marketing. Design/methodology/approach Lab experiments conducted among female and male participants using vanillin as a stimulus and ratings of sweetness, taste pleasantness and eating of sugar-free food as measures. Findings Odor-induced taste enhancement is gender-specific. Female consumers outperform male consumers in olfactory reaction and sweetness perception. While men outperform women in food consumption. Research limitations/implications Odor intensity was set to the concentration level of 0.00005per cent according to the findings from (Fujimaru and Lim, 2013). The authors believe that this intensity level is appropriate for both men and women. Still, there may be some gender effects on intensity levels, which are not explored here. The author’s test for the effects of one personal factor, gender and odor-induced taste enhancement of sugar-free food. The authors think that investigating the combined effects of more personal factors such as age, culture and so on adds to the accuracy of the results. Practical implications It seems that the stronger sensory capacities of women in terms of odor detection and recognition already confirmed in the literature extends to the cross-modal effects of this sensory detection and recognition on taste enhancement. It seems appropriate to tailor olfactory food advertising according to the gender of the target audience. Originality/value Odor-induced taste enhancement is still a novel subject in marketing. While most of the research has investigated the effects of smelling congruent odors on taste perception and food consumption among mixed groups of men and women, the value of this paper lies in the investigation of the potential moderating effects of gender on this relationship.

scholarly journals Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

2019 ◽  
Vol 44 (12) ◽  
pp. 2022-2029 ◽  
Author(s):  
E. Andrew Townsend ◽  
S. Stevens Negus ◽  
S. Barak Caine ◽  
Morgane Thomsen ◽  
Matthew L. Banks
Keyword(s):  
Sex Differences ◽  
Food Choice ◽  
Choice Procedure
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