Relationship of progressively increasing albuminuria to apoprotein(a) and blood pressure in Type 2 (non-insulin-dependent) and Type 1 (insulin-dependent) diabetic patients

Diabetologia ◽  
1993 ◽  
Vol 36 (10) ◽  
pp. 1037-1044 ◽  
Author(s):  
G. Jerums ◽  
T. J. Allen ◽  
C. Tsalamandris ◽  
A. Akdeniz ◽  
A. Sinha ◽  
...  
Diabetologia ◽  
1993 ◽  
Vol 36 (10) ◽  
pp. 1051-1056 ◽  
Author(s):  
C. Hasslacher ◽  
A. Bostedt-Kiesel ◽  
H. P. Kempe ◽  
P. Wahl

2017 ◽  
Vol 11 (3) ◽  
pp. 206-216 ◽  
Author(s):  
Kevin P. Haddix ◽  
R. Carter Clement ◽  
Joshua N. Tennant ◽  
Robert F. Ostrum

Background: Diabetics with ankle fractures experience more complications than the general population, but it is unclear whether complications differ between type 1 and 2 diabetics and between insulin- and non–insulin-dependent diabetics. This study aims to determine if there is a difference in postoperative complication rates between these groups. Methods: An administrative health care database from a large commercial insurer was queried to identify operatively treated ankle fractures in patients with type 1 (T1D), type 2 (T2D), type 2 insulin-dependent (T2ID), and type 2 non–insulin-dependent (T2NID) diabetes. Postoperative complications were identified to include postoperative stiffness, posttraumatic arthritis, amputation, implant removal, and infection. Subgroup analysis was performed to control for comorbidities. Results: A total of 20 703 closed and 2873 open operatively treated ankle fractures were identified. Patients with T1D experienced higher rates of amputation, postoperative infection, and total complications than patients with T2D (P < .05). Patients with T2ID experienced higher rates of amputation, infection, and total complications than those with T2NID (P < .0001). Subgroup analysis controlling for comorbidities showed a higher total complication rate for T1D compared with T2D in closed ankle fractures (P < .02) and for T2ID compared with T2NID in both open and closed ankle fractures (P < .0001). Conclusions: Patients with T1D and T2ID have higher complication rates than patients with T2D and T2NID, respectively. Foot and ankle surgeons should be cautioned not to classify diabetics as one cohort and should use these findings to stratify risk among this patient population. Levels of Evidence: Level III: Diagnostic


1993 ◽  
Vol 138 (3) ◽  
pp. 565-572 ◽  
Author(s):  
M. Tepel ◽  
S. Bauer ◽  
S. Husseini ◽  
A. Raffelsiefer ◽  
W. Zidek

ABSTRACT Cytosolic free sodium concentrations ([Na+]i) in intact platelets from 32 type 2 (non-insulin-dependent) diabetic patients and from 27 age- and sex-matched non-diabetic control subjects were measured with the novel sodium-sensitive fluorescent dye sodium-binding-benzofuran-isophthalate. [Na+]i was significantly higher in platelets from type 2 diabetic patients compared with control subjects (40·6 ± 2·4 vs 32·0 ± 2·0 mmol/l, means ± s.e.m., P<0·03). Both systolic and diastolic blood pressure were significantly elevated in diabetic patients compared with control subjects. Analysis of diabetic patients showed a significant association between [Na+]i and diastolic blood pressure (P =0·026). Stimulation of Na/H exchange by thrombin increased [Na+]i in both groups. After inhibition of Na/K/ATPase by ouabain (1 mmol/l), [Na+]i was significantly increased both in diabetic patients and non-diabetic subjects in a similar way (by 40·2 ± 7·3 and 31·7 ± 5·3 mmol/l respectively). It is concluded that increased [Na+]i in cells from type 2 diabetic patients may be related to hypertension. Journal of Endocrinology (1993) 138, 565–572


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