Effect of metabolic factors and blood pressure on kidney function in proteinuric Type 2 (non-insulin-dependent) diabetic patients

Diabetologia ◽  
1993 ◽  
Vol 36 (10) ◽  
pp. 1051-1056 ◽  
Author(s):  
C. Hasslacher ◽  
A. Bostedt-Kiesel ◽  
H. P. Kempe ◽  
P. Wahl
Diabetologia ◽  
1993 ◽  
Vol 36 (10) ◽  
pp. 1071-1078 ◽  
Author(s):  
M. -A. Gall ◽  
F. S. Nielsen ◽  
U. M. Smidt ◽  
H. -H. Parving

Diabetologia ◽  
1993 ◽  
Vol 36 (10) ◽  
pp. 1037-1044 ◽  
Author(s):  
G. Jerums ◽  
T. J. Allen ◽  
C. Tsalamandris ◽  
A. Akdeniz ◽  
A. Sinha ◽  
...  

1993 ◽  
Vol 138 (3) ◽  
pp. 565-572 ◽  
Author(s):  
M. Tepel ◽  
S. Bauer ◽  
S. Husseini ◽  
A. Raffelsiefer ◽  
W. Zidek

ABSTRACT Cytosolic free sodium concentrations ([Na+]i) in intact platelets from 32 type 2 (non-insulin-dependent) diabetic patients and from 27 age- and sex-matched non-diabetic control subjects were measured with the novel sodium-sensitive fluorescent dye sodium-binding-benzofuran-isophthalate. [Na+]i was significantly higher in platelets from type 2 diabetic patients compared with control subjects (40·6 ± 2·4 vs 32·0 ± 2·0 mmol/l, means ± s.e.m., P<0·03). Both systolic and diastolic blood pressure were significantly elevated in diabetic patients compared with control subjects. Analysis of diabetic patients showed a significant association between [Na+]i and diastolic blood pressure (P =0·026). Stimulation of Na/H exchange by thrombin increased [Na+]i in both groups. After inhibition of Na/K/ATPase by ouabain (1 mmol/l), [Na+]i was significantly increased both in diabetic patients and non-diabetic subjects in a similar way (by 40·2 ± 7·3 and 31·7 ± 5·3 mmol/l respectively). It is concluded that increased [Na+]i in cells from type 2 diabetic patients may be related to hypertension. Journal of Endocrinology (1993) 138, 565–572


Diabetologia ◽  
1984 ◽  
Vol 27 (5) ◽  
pp. 522-526 ◽  
Author(s):  
P. M. Dodson ◽  
P. J. Pacy ◽  
P. Bal ◽  
A. J. Kubicki ◽  
R. F. Fletcher ◽  
...  

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