The effect of packed cells and whole blood transfusions on survival after curative resection for colorectal carcinoma

1989 ◽  
Vol 32 (9) ◽  
pp. 743-748 ◽  
Author(s):  
Theo Wobbes ◽  
Kees H. G. Joosen ◽  
Han H. C. Kuypers ◽  
Gerard I. J. M. Beerthuizen ◽  
Ad G. M. Theeuwes
Keyword(s):  
Colorectal Carcinoma ◽  
Whole Blood ◽  
Curative Resection ◽  
Blood Transfusions

Perioperative blood transfusions do not affect disease recurrence of patients undergoing curative resection of colorectal carcinoma: a Mayo/North Central Cancer Treatment Group study.

1995 ◽  
Vol 13 (7) ◽  
pp. 1671-1678 ◽  
Author(s):  
J H Donohue ◽  
S Williams ◽  
S Cha ◽  
H E Windschitl ◽  
T E Witzig ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Colorectal Carcinoma ◽  
Whole Blood ◽  
Tumor Recurrence ◽  
Patient Survival ◽  
Tumor Stage ◽  
Disease Recurrence ◽  
Blood Transfusions ◽  
Blood Components ◽  
Cell Kinetic

PURPOSE To evaluate the effect of perioperative blood transfusions on colorectal cancer recurrence and patient survival. PATIENTS AND METHODS A total of 1,051 patients treated with curative surgery for stage II or III colorectal adenocarcinoma were retrospectively studied for the effect of perioperative blood transfusions on disease recurrence and patient survival. Forty-two percent of patients received perioperative blood components. RESULTS Perioperative transfusions had no effect on disease progression in univariate or multivariate analysis. Tumor stage (P = .0001), locally advanced tumor characteristics (adherence, involvement of adjacent structure, or perforation; P = .0001), location (rectal v colon; P = .0002), grade (P < .001), and cell kinetic profile (nondiploid or high percent synthetic phase [%S]+ percent gap 2 mitosis phase [%G2M]; P = .0003) were the most powerful independent predictors of tumor recurrence. Use of transfusions was associated with an adverse effect on overall survival (P < .004) using multivariate analysis, as well as tumor stage (P = .0001), location (P = .004), grade (P = .001), patient age (P = .0001), sex (P < .04), and cell kinetic profile (P = .0001). In further evaluation of the prognostic effects of transfusions, there was no increased risk of disease recurrence after whole-blood transfusion (P = .14) as compared with packed RBC or no transfusions, although the disease-specific survival for patients who received whole blood was lower than for nontransfused patients (P < .0005) patients who received other blood components (P < .03). CONCLUSION With transfusion practices that use blood components, most commonly RBCs, medically indicated transfusions to patients with colorectal carcinoma seem to have no impact on disease recurrence. The adverse impact of transfusions on cancer patient survival is more likely due to other unevaluated tumor variables or underlying illness rather than tumor recurrence enhancement by immunosuppression induced by transfusion of blood components.

scholarly journals Clinical application of carbon nanoparticles in curative resection for colorectal carcinoma

2017 ◽  
Vol Volume 10 ◽  
pp. 5585-5589 ◽  
Author(s):  
Li-yu Wang ◽  
Jia-huan Li ◽  
Xing Zhou ◽  
Qi-chang Zheng ◽  
Xiang Cheng
Keyword(s):  
Colorectal Carcinoma ◽  
Clinical Application ◽  
Carbon Nanoparticles ◽  
Curative Resection

Whole Blood Transfusions in Surgical Practice

1959 ◽  
Vol 39 (1) ◽  
pp. 121-131 ◽  
Author(s):  
Thomas W. Shields ◽  
Walter A. Rambach
Keyword(s):  
Whole Blood ◽  
Blood Transfusions ◽  
Surgical Practice

EFFECTS OF FRESH PLASMA OR WHOLE BLOOD TRANSFUSIONS ON PATIENTS WITH VARIOUS TYPES OF MUCOPOLYSACCHARIDOSIS

PEDIATRICS ◽  
1972 ◽  
Vol 50 (5) ◽  
pp. 688-692
Author(s):  
Anatole S. Dekaban ◽  
Kenton R. Holden ◽  
George Constantopoulos
Keyword(s):  
Molecular Weight ◽  
Weight Distribution ◽  
Whole Blood ◽  
Blood Transfusions ◽  
Molecular Weights ◽  
The Third ◽  
Clinical Observations ◽  
Before And After ◽  
Fresh Plasma

Repeated fresh plasma or whole blood transfusions were given to five patients with either Hurler, Hunter, or Sanfilippo types of mucopolysaccharidosis. Clinical observations and total 24-hour urinary AMPS and their composition and molecular weight distribution were determined before, during, and after transfusions. The two patients who received plasma transfusions showed no noticeable change in the amount of AMPS excreted; of the three patients who received whole blood transfusions, two had slightly less excretion of AMPS while the third showed no difference. The AMPS in the CSF were measured in one patient before and after blood transfusions and found to be unchanged; likewise, the determination of molecular weights in the isolated AMPS was virtually identical. In the patients studied, the transfusions caused no demonstrable difference in the patients' clinical condition.

The Role of Serum Carcinoembryonic Antigen (CEA) in the Management of Patients with Colorectal Carcinoma: The Experience of the Istituto Tumori of Milan

1992 ◽  
Vol 7 (3) ◽  
pp. 167-170 ◽  
Author(s):  
E. Seregni ◽  
E. Bombardieri ◽  
A. Bogni ◽  
F. Crippa ◽  
E. de Jager ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Clinical Management ◽  
Curative Resection ◽  
Recurrent Disease ◽  
Clinical Stage ◽  
Serum Levels ◽  
Serum Carcinoembryonic Antigen ◽  
Positive Results

CEA determination has attained an important role in the clinical management of patients with tumors of the colorectal tract. In this paper the experience of the Istituto Tumori of Milan is reviewed and the results are discussed. Three hundred and thirty-six patients were followed after curative resection of colorectal carcinoma. The follow-up period was 15 years, from January 1975 to December 1990 (global follow-up 1358 years). In the course of follow-up 136 patients developed recurrent disease. The number of CEA determinations for each patient ranged from 1 to 37 (mean 8, total 3330). CEA levels of presurgical patients were related to the clinical stage. Among patients who developed recurrences 61% showed an increase in CEA serum levels. In 200 patients with a negative follow-up we observed only 15 cases of false-positive results.

A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: Gastrointestinal Tumor Study Group Protocol 6584.

1991 ◽  
Vol 9 (7) ◽  
pp. 1105-1112 ◽  
Author(s):  
G Steele ◽  
R Bleday ◽  
R J Mayer ◽  
A Lindblad ◽  
N Petrelli ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Median Survival ◽  
Curative Resection ◽  
Hepatic Metastases ◽  
Prospective Evaluation ◽  
Resection Group ◽  
Poor Predictor ◽  
Asymptomatic Patients ◽  
Noncurative Resection

We report here the results of the first multiinstitutional prospective evaluation of patients considered to have potentially resectable hepatic metastases from colorectal carcinoma. One hundred fifty-six patients were enrolled from 15 institutions. Six patients were subsequently excluded. One hundred fifty patients underwent surgery and are evaluable for analysis (median follow-up time, 3.1 years; range, 4 months to 5.1 years). Curative resection could be performed on 46% of patients (69 of 150), noncurative resection on 12% (18 of 150), while 42% were found to be unresectable (63 of 150). Thirty-day surgical mortality and morbidity rates in patients with attempted resection were 2.7% and 13%, respectively. The curative resection group was observed to have an improved median survival (37.1 months) compared with the noncurative resection group (21.2 months) and the unresectable group (16.5 months) (P less than .01). Computed tomographic (CT) scan was a poor predictor for resectability, and age was not a contraindication to curative resection. Preoperative carcinoembryonic antigen (CEA) values were also a poor predictor for resectability. However, the median CEA value 61 to 180 days postsurgery was significantly higher in unresectable patients compared with median CEA levels in noncuratively and curatively resected groups (P less than .01). Our results imply that curative resection leads to an increase in median survival. Noncurative resection provides no benefit to asymptomatic patients, since unresectable and noncurative resection groups have similar life expectancies. Longer follow-up will be needed to demonstrate the ultimate impact of curative resection on survival.

Whole blood transfusions in 91 cats: A clinical evaluation

2004 ◽  
Vol 6 (3) ◽  
pp. 139-148 ◽  
Author(s):  
C. Weingart ◽  
U. Giger ◽  
B. Kohn
Keyword(s):  
Clinical Evaluation ◽  
Whole Blood ◽  
Blood Transfusions

The value of intensive follow-up after curative resection for colorectal carcinoma

1982 ◽  
Vol 69 (12) ◽  
pp. 725-728 ◽  
Author(s):  
A. Törnqvist ◽  
G. Ekelund ◽  
L. Leandoer
Keyword(s):  
Colorectal Carcinoma ◽  
Curative Resection
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