Perioperative blood transfusions do not affect disease recurrence of patients undergoing curative resection of colorectal carcinoma: a Mayo/North Central Cancer Treatment Group study.

1995 ◽  
Vol 13 (7) ◽  
pp. 1671-1678 ◽  
Author(s):  
J H Donohue ◽  
S Williams ◽  
S Cha ◽  
H E Windschitl ◽  
T E Witzig ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Colorectal Carcinoma ◽  
Whole Blood ◽  
Tumor Recurrence ◽  
Patient Survival ◽  
Tumor Stage ◽  
Disease Recurrence ◽  
Blood Transfusions ◽  
Blood Components ◽  
Cell Kinetic

PURPOSE To evaluate the effect of perioperative blood transfusions on colorectal cancer recurrence and patient survival. PATIENTS AND METHODS A total of 1,051 patients treated with curative surgery for stage II or III colorectal adenocarcinoma were retrospectively studied for the effect of perioperative blood transfusions on disease recurrence and patient survival. Forty-two percent of patients received perioperative blood components. RESULTS Perioperative transfusions had no effect on disease progression in univariate or multivariate analysis. Tumor stage (P = .0001), locally advanced tumor characteristics (adherence, involvement of adjacent structure, or perforation; P = .0001), location (rectal v colon; P = .0002), grade (P < .001), and cell kinetic profile (nondiploid or high percent synthetic phase [%S]+ percent gap 2 mitosis phase [%G2M]; P = .0003) were the most powerful independent predictors of tumor recurrence. Use of transfusions was associated with an adverse effect on overall survival (P < .004) using multivariate analysis, as well as tumor stage (P = .0001), location (P = .004), grade (P = .001), patient age (P = .0001), sex (P < .04), and cell kinetic profile (P = .0001). In further evaluation of the prognostic effects of transfusions, there was no increased risk of disease recurrence after whole-blood transfusion (P = .14) as compared with packed RBC or no transfusions, although the disease-specific survival for patients who received whole blood was lower than for nontransfused patients (P < .0005) patients who received other blood components (P < .03). CONCLUSION With transfusion practices that use blood components, most commonly RBCs, medically indicated transfusions to patients with colorectal carcinoma seem to have no impact on disease recurrence. The adverse impact of transfusions on cancer patient survival is more likely due to other unevaluated tumor variables or underlying illness rather than tumor recurrence enhancement by immunosuppression induced by transfusion of blood components.

Influence of blood transfusions on tumor recurrence and survival rate in colorectal carcinoma

1990 ◽  
Vol 26 (3) ◽  
pp. 327-335 ◽  
Author(s):  
F. Liewald ◽  
R.P. Wirsching ◽  
C. Zülke ◽  
N. Demmel ◽  
W. Mempel
Keyword(s):  
Survival Rate ◽  
Colorectal Carcinoma ◽  
Tumor Recurrence ◽  
Blood Transfusions

Hypercoagulation Screening As a Marker of Thrombosis and Poor Disease Prognosis in Cancer Patients: The Hypercan Prospective Study

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 586-586
Author(s):  
Marina R Marchetti ◽  
Giovanna Masci ◽  
Armando Santoro ◽  
Filippo de Braud ◽  
Luigi Celio ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Median Time ◽  
Whole Blood ◽  
Anticancer Therapy ◽  
Tumor Stage ◽  
Disease Recurrence ◽  
Response To Therapy ◽  
Kaplan Meier ◽  
Venous Thromboembolic Events ◽  
D Dimer

Abstract Introduction Malignant tumor progression and poor prognosis have been repeatedly associated with the occurrence of hypercoagulation and overt thrombotic events. The HYPERCAN is an ongoing prospective Italian multicentre study, structured in two sub-projects that involve respectively non-cancer and cancer subjects. The HYPERCAN sub-project on cancer patients aims to evaluate whether thrombotic markers may predict for malignant disease recurrence and/or for venous thromboembolic events (VTE) in these patients. Methods Consecutive adult patients with limited resected or metastatic non-small cell-lung (NSCLC), gastric, colorectal, or breast cancers are enrolled, after informed written consent, and followed up for 5 years or death. Enrollment will be continued for up to 3 years (total 4,000 patients planned). Blood sample collection is planned according to tumor stage. Particularly, for metastatic disease, patient citrated whole blood is collected: 1. at enrollment, 2. after the 3rd cycle of anticancer therapy, 3. after the 6thcycle of anticancer therapy, 4. at the end of treatment, or earlier if disease progression. For patients with limited disease, whole blood samples are collected at enrollment (i.e. after surgery, before starting any medical anticancer treatment), and thereafter once a year for 4 years, or at disease recurrence. At each time point, information on treatment, clinical response, and disease outcome, are collected. Plasma samples and clinical information are centralized at the Division of Immunohematology and Transfusion Medicine - Bergamo Hospital (coordinating center). Patient plasma is tested for a preliminary panel of hemostatic markers (D-dimer, Fibrinogen) and thrombin generation (TG). Results Between April 2012 and February 2014, 1,113 cancer patients were enrolled into the study. Follow-up data were available for 1,045 patients (359 metastatic/686 limited-resected) with NSCLC (n=252), gastric (n=74), colorectal (n=163) and breast (n=556) cancers, with an observation median time of 340 days. Forty-eight patients (4.6%) developed VTE with a median time of 123 days from enrollment. VTE was more frequent in metastatic compared to limited resected cancer patients (9.2% vs 2.2%); colorectal and lung cancer patients showed the highest VTE rate, 8.5% and 7.9%, respectively, independently of tumor stage. Currently plasma from 474 patients (196 metastatic/278 limited resected) were tested. Increased D-dimer and fibrinogen levels at enrollment showed to be significant risk factors for VTE by Kaplan-Meier analysis (HR: 5.4, 95% CI 2.2-13.2 p=0.000 for D-dimer; HR: 4.3, 95% CI 1.8-10.4 p=0.004 for fibrinogen) as well as the endogenous thrombin potential (HR: 4.5, 95% CI 1.8-11.4 p=0.000) and the TG peak (HR: 4.0, 95% CI 1.5-10.2 p=0.009). In the group with limited resected disease, the cumulative incidence of recurrence was 3.2% with a median time of 186 days. Increased D-dimer and fibrinogen levels at enrollment were predictive for disease recurrence by Kaplan-Meier analysis (HR: 9.9, 95% CI 2.4-40.1 p=0.001 for D-dimer; HR: 5.9, 95% CI 1.5-23.6 p=0.012 for fibrinogen). Conclusions These early results reveal that tumor stage and site, as well as elevated levels of D-dimer, fibrinogen and TG at enrollment, are associated with an increased risk of VTE in cancer patients. In subjects with limited resected cancer, elevated D-dimer and fibrinogen levels also predict for disease recurrence. These results support the hypothesis that testing for relatively easy plasma markers of thrombosis may be worth for monitoring the cancer response to therapy beyond the thrombotic risk. Project funded by AIRC “5xMILLE” n. 12237 grant from the “Italian Association for Cancer Research (AIRC)”. Disclosures No relevant conflicts of interest to declare.

The effect of packed cells and whole blood transfusions on survival after curative resection for colorectal carcinoma

1989 ◽  
Vol 32 (9) ◽  
pp. 743-748 ◽  
Author(s):  
Theo Wobbes ◽  
Kees H. G. Joosen ◽  
Han H. C. Kuypers ◽  
Gerard I. J. M. Beerthuizen ◽  
Ad G. M. Theeuwes
Keyword(s):  
Colorectal Carcinoma ◽  
Whole Blood ◽  
Curative Resection ◽  
Blood Transfusions

Tumor recurrence and survival following gamma knife surgery for brain metastases

2005 ◽  
Vol 102 (Special_Supplement) ◽  
pp. 287-288 ◽  
Author(s):  
Thomas Mindermann
Keyword(s):  
Brain Metastasis ◽  
Brain Metastases ◽  
Gamma Knife ◽  
Tumor Recurrence ◽  
Patient Survival ◽  
Gamma Knife Surgery ◽  
Recurrence Rates ◽  
Term Survival ◽  
Content Type ◽  
Fine Print

Object. The authors evaluated prognostic factors for tumor recurrence and patient survival following gamma knife surgery (GKS) for brain metastasis. Methods. A retrospective review of 101 patient charts was undertaken for those patients treated with GKS for brain metastases from 1994 to 2001. Recurrence rates of brain metastasis following GKS depended on the duration of patient survival. Long-term survival was associated with a higher risk of tumor recurrence and shorter-term survival was associated with a lower risk. The duration of survival following GKS for brain metastases seems to be characteristic of the primary disease rather than the cerebral disease. Conclusions. Recurrence rates of brain metastasis following GKS are related to duration of survival, which is in turn mostly dependent on the nature and course of the primary tumor.

scholarly journals Survey to inform trial of low‐titer group O whole‐blood compared to conventional blood components for children with severe traumatic bleeding

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Julia H. Kolodziej ◽  
Julie C. Leonard ◽  
Cassandra D. Josephson ◽  
Barbara A. Gaines ◽  
Stephen R. Wisniewski ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Components ◽  
Titer Group ◽  
Traumatic Bleeding

scholarly journals Whole blood and blood components from vertebrates differentially affect egg formation in three species of anautogenous mosquitoes

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ruby E. Harrison ◽  
Mark R. Brown ◽  
Michael R. Strand
Keyword(s):  
Serum Albumin ◽  
Whole Blood ◽  
Digestive Enzyme ◽  
Vertebrate Host ◽  
Cell Protein ◽  
Blood Components ◽  
Blood Proteins ◽  
Serum Albumins ◽  
Egg Formation ◽  
Reproductive Response

Abstract Background Most female mosquitoes are anautogenous and must blood feed on a vertebrate host to produce eggs. Prior studies show that the number of eggs females lay per clutch correlates with the volume of blood ingested and that protein is the most important macronutrient for egg formation. In contrast, how whole blood, blood fractions and specific blood proteins from different vertebrates affect egg formation is less clear. Since egg formation is best understood in Aedes aegypti, we examined how blood and blood components from different vertebrates affect this species and two others: the malaria vector Anopheles gambiae and arbovirus vector Culex quinquefasciatus. Methods Adult female mosquitoes were fed blood, blood fractions and purified major blood proteins from different vertebrate hosts. Markers of reproductive response including ovary ecdysteroidogenesis, yolk deposition into oocytes and number of mature eggs produced were measured. Results Ae. aegypti, An. gambiae and C. quinquefasciatus responded differently to meals of whole blood, plasma or blood cells from human, rat, chicken and turkey hosts. We observed more similarities between the anthropophiles Ae. aegypti and An. gambiae than the ornithophile C. quinquefasciatus. Focusing on Ae. aegypti, the major plasma-derived proteins (serum albumin, fibrinogen and globulins) differentially stimulated egg formation as a function of vertebrate host source. The major blood cell protein, hemoglobin, stimulated yolk deposition when from pigs but not humans, cows or sheep. Serum albumins from different vertebrates also variably affected egg formation. Bovine serum albumin (BSA) stimulated ovary ecdysteroidogenesis, but more weakly induced digestive enzyme activities than whole blood. In contrast, BSA-derived peptides and free amino acids had no stimulatory effects on ecdysteroidogenesis or yolk deposition into oocytes. Conclusions Whole blood, blood fractions and specific blood proteins supported egg formation in three species of anautogenous mosquitoes but specific responses varied with the vertebrate source of the blood components tested.

scholarly journals Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Walid El Moghazy ◽  
Samy Kashkoush ◽  
Glenda Meeberg ◽  
Norman Kneteman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Tumor Recurrence ◽  
Patient Survival ◽  
Steady Increase ◽  
Liver Transplants ◽  
Significant Difference ◽  
One Year ◽  
Over Time

Background. We aimed to assess incidentally discovered hepatocellular carcinoma (iHCC) over time and to compare outcome to preoperatively diagnosed hepatocellular carcinoma (pdHCC) and nontumor liver transplants.Methods.We studied adults transplanted with a follow-up of at least one year. Patients were divided into 3 groups according to diagnosis of hepatocellular carcinoma.Results.Between 1990 and 2010, 887 adults were transplanted. Among them, 121 patients (13.6%) had pdHCC and 32 patients (3.6%) had iHCC; frequency of iHCC decreased markedly over years, in parallel with significant increase in pdHCC. Between 1990 and 1995, 120 patients had liver transplants, 4 (3.3%) of them had iHCC, and only 3 (2.5%) had pdHCC, while in the last 5 years, 263 patients were transplanted, 7 (0.03%) of them had iHCC, and 66 (25.1%) had pdHCC (P<0.001). There was no significant difference between groups regarding patient survival; 5-year survival was 74%, 75.5%, and 77.3% in iHCC, pdHCC, and non-HCC groups, respectively (P=0.702). Patients with iHCC had no recurrences after transplant, while pdHCC patients experienced 17 recurrences (15.3%) (P=0.016).Conclusions.iHCC has significantly decreased despite steady increase in number of transplants for hepatocellular carcinoma. Patients with iHCC had excellent outcomes with no tumor recurrence and survival comparable to pdHCC.

Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival

2001 ◽  
Vol 194 (4) ◽  
pp. 436-443 ◽  
Author(s):  
Mohamed A. Elkablawy ◽  
Perry Maxwell ◽  
Kate Williamson ◽  
Neil Anderson ◽  
Peter W. Hamilton
Keyword(s):  
Cell Cycle ◽  
Colorectal Carcinoma ◽  
Patient Survival ◽  
Regulatory Proteins ◽  
Tumour Stage ◽  
Cell Cycle Regulatory Proteins
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