Heterogeneous secretion of gelatinolytic enzymes in human renal cell carcinoma cell lines and correlation with the invasive behaviour in vitro

1995 ◽  
Vol 121 (S1) ◽  
pp. A62-A62
Author(s):  
A. Donner ◽  
R. Engers ◽  
S. Mrzyk ◽  
C. D. Gerharz ◽  
H. E. Gabbert
2014 ◽  
Vol 14 (1) ◽  
pp. 63 ◽  
Author(s):  
Lichen Teng ◽  
Dexin Ding ◽  
Yongsheng Chen ◽  
Hongshuang Dai ◽  
Guobin Liu ◽  
...  

2007 ◽  
Vol 98 (4) ◽  
pp. 529-534 ◽  
Author(s):  
Toru Shimazui ◽  
Yoshihiro Ami ◽  
Kazuhiro Yoshikawa ◽  
Kazuhiko Uchida ◽  
Takahiro Kojima ◽  
...  

Tumor Biology ◽  
2017 ◽  
Vol 39 (5) ◽  
pp. 101042831770163 ◽  
Author(s):  
Wen Huang ◽  
Xiao-Long Wei ◽  
WeiWei Ni ◽  
Mengda Cao ◽  
Ling Meng ◽  
...  

RBM38, a member of RNA recognition motif family of RNA-binding proteins, can regulate the expression of diverse targets by influencing their messenger RNA stability and play a vital role in cancer development. RBM38 may act as an oncogene or suppressor gene in several human tumors. However, its role in human renal cell carcinoma remains unclear. In this study, we found that the expression of RBM38 was lower in renal cell carcinoma tissues and cell lines. Moreover, overexpression of RBM38 could reduce, whereas knockdown of RBM38 could accelerate renal cell carcinoma cell lines growth rate and number of colonies formation of renal cell carcinoma cell lines. Furthermore, RBM38 inhibited renal cell carcinoma cell lines migration and invasion through epithelial–mesenchymal transition suppression by up-regulating E-cadherin and down-regulating β-catenin and vimentin. For in vivo assays, we found that the RBM38-positive group CAKI-1-RBM38 formed smaller tumors in nude mice compared with the control group. Kaplan–Meier analysis showed that renal cell carcinoma patients with lower expression of RBM38 had a significantly shorter survival time than those with higher expression of RBM38 ( p = 0.028). All these suggested that RBM38 acts as a tumor suppressor in renal cell carcinoma, which has the potential value for the prediction of renal cell carcinoma prognosis.


1999 ◽  
Vol 189 (2) ◽  
pp. 95-105 ◽  
Author(s):  
Makoto Satoh ◽  
Fatemeh Moosavi Nejad ◽  
Osamu Nakano ◽  
Akihiro Ito ◽  
Sadafumi Kawamura ◽  
...  

1996 ◽  
Vol 14 (5) ◽  
pp. 466-474 ◽  
Author(s):  
Yoshifumi Nakayama ◽  
Seiji Naito ◽  
Masahiro Ryuto ◽  
Yasuaki Hata ◽  
Mayumi Ono ◽  
...  

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