Bioartificial endocrine pancreas: foreign-body reaction and effectiveness of diffusional transport of insulin and oxygen after long-term implantation of hollow fibers into rats

The implantation of any foreign material into the body leads to the development of an inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a tissue, cells of the immune system become attracted to the foreign material and attempt to degrade it. If this degradation fails, fibroblasts envelop the material and form a physical barrier to isolate it from the rest of the body. Long-term implantation of medical devices faces a great challenge presented by FBR, as the cellular response disrupts the interface between implant and its target tissue. This is particularly true for nerve neuroprosthetic implants—devices implanted into nerves to address conditions such as sensory loss, muscle paralysis, chronic pain, and epilepsy. Nerve neuroprosthetics rely on tight interfacing between nerve tissue and electrodes to detect the tiny electrical signals carried by axons, and/or electrically stimulate small subsets of axons within a nerve. Moreover, as advances in microfabrication drive the field to increasingly miniaturized nerve implants, the need for a stable, intimate implant-tissue interface is likely to quickly become a limiting factor for the development of new neuroprosthetic implant technologies. Here, we provide an overview of the material-cell interactions leading to the development of FBR. We review current nerve neuroprosthetic technologies (cuff, penetrating, and regenerative interfaces) and how long-term function of these is limited by FBR. Finally, we discuss how material properties (such as stiffness and size), pharmacological therapies, or use of biodegradable materials may be exploited to minimize FBR to nerve neuroprosthetic implants and improve their long-term stability.

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Time course study of long-term biocompatibility and foreign body reaction to intraneural polyimide-based implants

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.36274 ◽

2017 ◽

Vol 106 (3) ◽

pp. 746-757 ◽

Cited By ~ 17

Author(s):

Natàlia de la Oliva ◽

Xavier Navarro ◽

Jaume del Valle

Keyword(s):

Foreign Body ◽

Time Course ◽

Foreign Body Reaction ◽

Time Course Study

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Long-term evaluation of degradation and foreign-body reaction of subcutaneously implanted poly(DL-lactide-?-caprolactone)

Journal of Biomedical Materials Research ◽

10.1002/(sici)1097-4636(19970905)36:3<337::aid-jbm9>3.0.co;2-f ◽

1997 ◽

Vol 36 (3) ◽

pp. 337-346 ◽

Cited By ~ 61

Author(s):

W. F. A. den Dunnen ◽

P. H. Robinson ◽

R. van Wessel ◽

A. J. Pennings ◽

M. B. M. van Leeuwen ◽

...

Keyword(s):

Foreign Body ◽

Foreign Body Reaction ◽

Term Evaluation

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Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation

BioMed Research International ◽

10.1155/2014/510807 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

Holger Gerullis ◽

Evangelos Georgas ◽

Mihaly Borós ◽

Bernd Klosterhalfen ◽

Christoph Eimer ◽

...

Keyword(s):

Foreign Body ◽

Connective Tissue ◽

Inflammatory Reaction ◽

Inflammatory Infiltrate ◽

Foreign Body Reaction ◽

Plasma Coating ◽

Mesh Implantation ◽

Long Term Follow Up ◽

Infiltrate Macrophage

Purpose.To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model.Materials and Methods.Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months.Results.Macrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min.Conclusion.The local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.

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A peritoneal defect covered by intraperitoneal mesh prosthesis effects an increased and distinctive foreign body reaction in a minipig model

Journal of Biomaterials Applications ◽

10.1177/0885328220963918 ◽

2020 ◽

Vol 35 (6) ◽

pp. 732-739

Author(s):

Roman Marius Eickhoff ◽

Andreas Kroh ◽

Simon Eickhoff ◽

Daniel Heise ◽

Marius Julian Helmedag ◽

...

Keyword(s):

Foreign Body ◽

Polyvinylidene Fluoride ◽

Foreign Body Reaction ◽

Minimal Invasive ◽

Mesh Placement ◽

Mesh Prosthesis ◽

Onlay Mesh ◽

Intraperitoneal Onlay Mesh Technique ◽

Hydrogel Coating

Background The incidence of incisional hernia is with up to 30% one of the frequent long-term complication after laparotomy. After establishing minimal invasive operations, the laparoscopic intraperitoneal onlay mesh technique (lap. IPOM) was first described in 1993. Little is known about the foreign body reaction of IPOM-meshes, which covered a defect of the parietal peritoneum. This is becoming more important, since IPOM procedure with peritoneal-sac resection and hernia port closing (IPOM plus) is more frequently used. Methods In 18 female minipigs, two out of three Polyvinylidene-fluoride (PVDF) -meshes (I: standard IPOM; II: IPOM with modified structure [bigger pores]; III: IPOM with the same structure as IPOM II + degradable hydrogel-coating) were placed in a laparoscopic IPOM procedure. Before mesh placement, a 2x2cm peritoneal defect was created. After 30 days, animals were euthanized, adhesions were evaluated by re-laparoscopy and mesh samples were explanted for histological and immunohistochemichal investigations. Results All animals recovered after implantation and had no complications during the follow-up period. Analysing foreign body reaction, the IPOM II mesh had a significant smaller inner granuloma, compared to the other meshes (IPOM II: 8.4 µm ± 1.3 vs. IPOM I 9.1 µm ± 1.3, p < 0.001). The degradable hydrogel coating does not prevent adhesions measured by Diamond score (p = 0.46). A peritoneal defect covered by a standard or modified IPOM mesh was a significant factor for increasing foreign body granuloma, the amount of CD3+ lymphocytes, CD68+ macrophages and decrease of pore size. Conclusion A peritoneal defect covered by IPOM prostheses leads to an increased foreign body reaction compared to intact peritoneum. Whenever feasible, a peritoneal defect should be closed accurately before placing an IPOM-mesh to avoid an excessive foreign body reaction and therefore inferior biomaterial properties of the prosthesis.

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Clinicopathological Analysis of 90 Cases of Polyacrylamide Hydrogel Injection for Breast Augmentation Including 2 Cases Followed by Breast Cancer

Breast Care ◽

10.1159/000499832 ◽

2019 ◽

Vol 15 (1) ◽

pp. 38-44

Author(s):

Ying Yang ◽

Shumo Li ◽

Jia He ◽

Xian Zhao ◽

Wei Chen ◽

...

Keyword(s):

Breast Cancer ◽

Foreign Body ◽

Breast Augmentation ◽

Acute Inflammation ◽

Foreign Body Reaction ◽

Ductal Carcinoma ◽

Polyacrylamide Hydrogel ◽

Clinicopathological Analysis

Background: Although polyacrylamide hydrogel (PAAG) injection for breast augmentation has been prohibited for many years, the long-term complications will be significant for a long period. Few research articles have focused on the clinicopathological analysis. Materials and Methods: We summarized clinical and pathological features of 90 cases after PAAG-injected breast augmentation, including 2 cases of breast cancer developed following PAAG injection. Results: All patients were females between the ages of 30 and 64 years (mean, 44 years). The complications included masses (75.58%), pain (45.35%), migration (22.09%), deformation (18.60%), infection (16.28%), induration (4.65%), and psychological fear (2.33%). Microscopically, the PAAG presented as purple gel pools, and the foreign body reaction was noted in all 90 patients. The proportion of fibrous component exceeded 90% in 26 cases (28.89%). Chronic and acute inflammation was noted in 70 (77.78%) and 9 (10%) patients, respectively. The mammary gland around the gel displayed atrophy in 18 cases (20.00%), adenosis in 33 cases (36.67%), ductal carcinoma in situ in 1 case (1.11%), and invasive carcinoma in 1 case (1.11%). Conclusion: The long-term complications of PAAG-injected breast augmentation are various and complex. Pathologically, these complications are associated with foreign body reaction, fibrosis, and inflammation.

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Case Report: Late Complication of a Dry Socket Treatment

International Journal of Dentistry ◽

10.1155/2010/479306 ◽

2010 ◽

Vol 2010 ◽

pp. 1-4 ◽

Cited By ~ 3

Author(s):

Ramón Manuel Alemán Navas ◽

María Guadalupe Martínez Mendoza

Keyword(s):

Zinc Oxide ◽

Foreign Body ◽

Foreign Body Reaction ◽

Chronic Osteomyelitis ◽

Late Complication ◽

Complete Removal ◽

Affected Area ◽

Dry Socket ◽

Foreign Body Reactions

Dry socket is often treated in dentistry with intra-alveolar dressings; the use of them remains controversial and has been related to some side effects such as neuritis, foreign body reactions, and myospherulosis. We present a case of an intra-alveolar dressing (zinc-oxide eugenol paste) that mimicked a trigeminal neuralgia for 3 years and caused a right maxillary chronic osteomyelitis and foreign body reaction in a zone corresponding to the alveolus of the maxillary first molar. This long-term complication was successfully managed by complete removal of the foreign body and curettage of the affected area.

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Primary choledocholithiasis after long-term self-expansible metallic stent for ampullary carcinoma: A rare case

Journal of Digestive Endoscopy ◽

10.4103/0976-5042.165714 ◽

2015 ◽

Vol 6 (03) ◽

pp. 123-125

Author(s):

Mohan Joshi ◽

Ashwini Paranjpe ◽

Minakshi Gadhire

Keyword(s):

Foreign Body ◽

Rare Case ◽

Foreign Body Reaction ◽

Ampullary Carcinoma ◽

Ampullary Cancer ◽

Metallic Stent ◽

Periampullary Carcinoma ◽

Cbd Stones ◽

Stent Material

AbstractIn patients with periampullary carcinoma presenting in the inoperable stage, self-expansible metallic stents (SEMS) are preferred for palliation of jaundice. The primary common bile duct (CBD) stones are very rare in a patient who is treated with SEMS for ampullary cancer. We report here a case of primary CBD stones after 2 years of placement of SEMS, whether, reflux of duodenal contents or foreign body reaction to the stent material is the etiology of the formation of stone is a matter of debate.

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