A peritoneal defect covered by intraperitoneal mesh prosthesis effects an increased and distinctive foreign body reaction in a minipig model

2020 ◽  
Vol 35 (6) ◽  
pp. 732-739
Author(s):  
Roman Marius Eickhoff ◽  
Andreas Kroh ◽  
Simon Eickhoff ◽  
Daniel Heise ◽  
Marius Julian Helmedag ◽  
...  
Keyword(s):  
Foreign Body ◽  
Polyvinylidene Fluoride ◽  
Foreign Body Reaction ◽  
Minimal Invasive ◽  
Mesh Placement ◽  
Mesh Prosthesis ◽  
Onlay Mesh ◽  
Intraperitoneal Onlay Mesh Technique ◽  
Hydrogel Coating

Background The incidence of incisional hernia is with up to 30% one of the frequent long-term complication after laparotomy. After establishing minimal invasive operations, the laparoscopic intraperitoneal onlay mesh technique (lap. IPOM) was first described in 1993. Little is known about the foreign body reaction of IPOM-meshes, which covered a defect of the parietal peritoneum. This is becoming more important, since IPOM procedure with peritoneal-sac resection and hernia port closing (IPOM plus) is more frequently used. Methods In 18 female minipigs, two out of three Polyvinylidene-fluoride (PVDF) -meshes (I: standard IPOM; II: IPOM with modified structure [bigger pores]; III: IPOM with the same structure as IPOM II + degradable hydrogel-coating) were placed in a laparoscopic IPOM procedure. Before mesh placement, a 2x2cm peritoneal defect was created. After 30 days, animals were euthanized, adhesions were evaluated by re-laparoscopy and mesh samples were explanted for histological and immunohistochemichal investigations. Results All animals recovered after implantation and had no complications during the follow-up period. Analysing foreign body reaction, the IPOM II mesh had a significant smaller inner granuloma, compared to the other meshes (IPOM II: 8.4 µm ± 1.3 vs. IPOM I 9.1 µm ± 1.3, p < 0.001). The degradable hydrogel coating does not prevent adhesions measured by Diamond score (p = 0.46). A peritoneal defect covered by a standard or modified IPOM mesh was a significant factor for increasing foreign body granuloma, the amount of CD3+ lymphocytes, CD68+ macrophages and decrease of pore size. Conclusion A peritoneal defect covered by IPOM prostheses leads to an increased foreign body reaction compared to intact peritoneum. Whenever feasible, a peritoneal defect should be closed accurately before placing an IPOM-mesh to avoid an excessive foreign body reaction and therefore inferior biomaterial properties of the prosthesis.

A Nodular Foreign Body Reaction in a Dialysis Patient Receiving Long-term Treatment With Lanthanum Carbonate

2016 ◽  
Vol 67 (1) ◽  
pp. 128-132 ◽  
Author(s):  
Aziz K. Valika ◽  
Dhanpat Jain ◽  
Phillip E. Jaffe ◽  
Gilbert Moeckel ◽  
Ursula C. Brewster
Keyword(s):  
Foreign Body ◽  
Dialysis Patient ◽  
Foreign Body Reaction ◽  
Term Treatment ◽  
Lanthanum Carbonate ◽  
Long Term Treatment

Long-term foreign-body reaction to preperitoneal polypropylene mesh in the pig

Hernia ◽  
1998 ◽  
Vol 2 (4) ◽  
pp. 153-155 ◽  
Author(s):  
G. L. Beets ◽  
H. van Mameren ◽  
P. M. N. Y. H. Go
Keyword(s):  
Foreign Body ◽  
Polypropylene Mesh ◽  
Foreign Body Reaction

scholarly journals Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics

2021 ◽  
Vol 9 ◽  
Author(s):  
Alejandro Carnicer-Lombarte ◽  
Shao-Tuan Chen ◽  
George G. Malliaras ◽  
Damiano G. Barone
Keyword(s):  
Foreign Body ◽  
Cellular Response ◽  
Foreign Body Reaction ◽  
The Body ◽  
Nerve Tissue ◽  
Sensory Loss ◽  
Target Tissue ◽  
Foreign Material ◽  
Fibrotic Process

The implantation of any foreign material into the body leads to the development of an inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a tissue, cells of the immune system become attracted to the foreign material and attempt to degrade it. If this degradation fails, fibroblasts envelop the material and form a physical barrier to isolate it from the rest of the body. Long-term implantation of medical devices faces a great challenge presented by FBR, as the cellular response disrupts the interface between implant and its target tissue. This is particularly true for nerve neuroprosthetic implants—devices implanted into nerves to address conditions such as sensory loss, muscle paralysis, chronic pain, and epilepsy. Nerve neuroprosthetics rely on tight interfacing between nerve tissue and electrodes to detect the tiny electrical signals carried by axons, and/or electrically stimulate small subsets of axons within a nerve. Moreover, as advances in microfabrication drive the field to increasingly miniaturized nerve implants, the need for a stable, intimate implant-tissue interface is likely to quickly become a limiting factor for the development of new neuroprosthetic implant technologies. Here, we provide an overview of the material-cell interactions leading to the development of FBR. We review current nerve neuroprosthetic technologies (cuff, penetrating, and regenerative interfaces) and how long-term function of these is limited by FBR. Finally, we discuss how material properties (such as stiffness and size), pharmacological therapies, or use of biodegradable materials may be exploited to minimize FBR to nerve neuroprosthetic implants and improve their long-term stability.

Long-term evaluation of degradation and foreign-body reaction of subcutaneously implanted poly(DL-lactide-?-caprolactone)

1997 ◽  
Vol 36 (3) ◽  
pp. 337-346 ◽  
Author(s):  
W. F. A. den Dunnen ◽  
P. H. Robinson ◽  
R. van Wessel ◽  
A. J. Pennings ◽  
M. B. M. van Leeuwen ◽  
...  
Keyword(s):  
Foreign Body ◽  
Foreign Body Reaction ◽  
Term Evaluation

scholarly journals Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Holger Gerullis ◽  
Evangelos Georgas ◽  
Mihaly Borós ◽  
Bernd Klosterhalfen ◽  
Christoph Eimer ◽  
...  
Keyword(s):  
Foreign Body ◽  
Connective Tissue ◽  
Inflammatory Reaction ◽  
Inflammatory Infiltrate ◽  
Foreign Body Reaction ◽  
Plasma Coating ◽  
Mesh Implantation ◽  
Long Term Follow Up ◽  
Infiltrate Macrophage

Purpose.To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model.Materials and Methods.Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months.Results.Macrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min.Conclusion.The local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.

scholarly journals Clinicopathological Analysis of 90 Cases of Polyacrylamide Hydrogel Injection for Breast Augmentation Including 2 Cases Followed by Breast Cancer

Breast Care ◽  
2019 ◽  
Vol 15 (1) ◽  
pp. 38-44
Author(s):  
Ying Yang ◽  
Shumo Li ◽  
Jia He ◽  
Xian Zhao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Foreign Body ◽  
Breast Augmentation ◽  
Acute Inflammation ◽  
Foreign Body Reaction ◽  
Ductal Carcinoma ◽  
Polyacrylamide Hydrogel ◽  
Clinicopathological Analysis

Background: Although polyacrylamide hydrogel (PAAG) injection for breast augmentation has been prohibited for many years, the long-term complications will be significant for a long period. Few research articles have focused on the clinicopathological analysis. Materials and Methods: We summarized clinical and pathological features of 90 cases after PAAG-injected breast augmentation, including 2 cases of breast cancer developed following PAAG injection. Results: All patients were females between the ages of 30 and 64 years (mean, 44 years). The complications included masses (75.58%), pain (45.35%), migration (22.09%), deformation (18.60%), infection (16.28%), induration (4.65%), and psychological fear (2.33%). Microscopically, the PAAG presented as purple gel pools, and the foreign body reaction was noted in all 90 patients. The proportion of fibrous component exceeded 90% in 26 cases (28.89%). Chronic and acute inflammation was noted in 70 (77.78%) and 9 (10%) patients, respectively. The mammary gland around the gel displayed atrophy in 18 cases (20.00%), adenosis in 33 cases (36.67%), ductal carcinoma in situ in 1 case (1.11%), and invasive carcinoma in 1 case (1.11%). Conclusion: The long-term complications of PAAG-injected breast augmentation are various and complex. Pathologically, these complications are associated with foreign body reaction, fibrosis, and inflammation.

Polyvinylidene Fluoride as a Suture Material: Evaluation of Comet Tail-Like Infiltrate and Foreign Body Granuloma

2015 ◽  
Vol 55 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Andreas Lambertz ◽  
Kai Michael Schröder ◽  
Dominik Stefan Schöb ◽  
Marcel Binnebösel ◽  
Michael Anurov ◽  
...  
Keyword(s):  
Foreign Body ◽  
Polyvinylidene Fluoride ◽  
Foreign Body Reaction ◽  
Suture Material ◽  
Foreign Body Granuloma ◽  
Male Rats ◽  
Comet Tail ◽  
Suture Materials ◽  
Tissue Integration

Background: Biocompatibility and tissue integration of a surgical suture are decisive factors for wound healing and therefore for the success of sutures. The optimal suture material is still under discussion. Polyvinylidene fluoride (PVDF) is described to have superior properties of biocompatibility and is therefore frequently used as a mesh component. Only little information is available about its use as a suture material. The aim of this study was to evaluate the biocompatibility of PVDF as a suture material in comparison to 5 different established sutures in a rat model. Methods: In 30 male rats, a monofilamental PVDF suture (Resopren®) and 5 established control suture materials [polyester (Miralene®), polytetrafluoroethylene (Gore®), poliglecaprone (Monocryl®), polydioxanone (Monoplus®), polyglactin 910 (Vicryl®), USP size 3-0] were placed in the subcutaneous layer of the abdominal wall without knot or tension. After 3, 7 or 21 days, the abdominal walls were explanted for histopathological and immunohistochemical investigation with special regard to the size and quality of foreign body granuloma and the length of the comet tail-like infiltrate (CTI). Results: The PVDF sutures showed the smallest size of foreign body granuloma (60 ± 14 µm) and the smallest CTI length (343 ± 60 µm) of all polymers after 21 days. Only PVDF (Resopren) and polydioxanone (Monoplus) showed a significant collagen I/III ratio increase between days 3 and 21 (p = 0.009 and p = 0.016). The quality of foreign body reaction regarding inflammation, proliferation and fibrotic remodeling was similar between all suture materials. Conclusions: Our data indicate that monofilamental PVDF sutures show a favorable foreign body reaction with small granuloma sizes and CTI length in comparison to established sutures. Its use as a suture material in general surgery could therefore be extended in the future. To reinforce these findings, further clinical studies need to be conducted.

scholarly journals Laparoscopic Removal of Gossypiboma

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Zeki Özsoy ◽  
Ismail Okan ◽  
Emin Daldal ◽  
Mehmet Fatih Dasıran ◽  
Yavuz Selim Angın ◽  
...  
Keyword(s):  
Laparoscopic Surgery ◽  
Foreign Body ◽  
Emergency Room ◽  
Acute Abdomen ◽  
Invasive Surgery ◽  
Minimal Invasive Surgery ◽  
Foreign Body Reaction ◽  
Laparoscopic Approach ◽  
Minimal Invasive ◽  
Laparoscopic Removal

Gossypiboma is defined as a mass caused by foreign body reaction developed around the retained surgical item in the operative area. When diagnosed, it should be removed in symptomatic patients. Minimal invasive surgery should be planned for the removal of the retained item. The number of cases treated by laparoscopic approach is rare in the literature. We present a case of forty-year-old woman referred to emergency room with acute abdomen diagnosed as gossypiboma and treated successfully with laparoscopic surgery.

Sign in / Sign up

Export Citation Format

Share Document