Mother-to-child transmission of hepatitis E virus infection

Mother-to-child transmission of hepatitis C virus infection occurs in a significant minority of cases and the diagnosis, treatment and cure of hepatitis C virus infection with direct acting antivirals prior to pregnancy can eliminate this risk in almost all cases. Women with hepatitis C virus infection have increased risks of adverse events in pregnancy and poor perinatal outcomes for their children, although the contribution of hepatitis C virus per se is difficult to determine. Altering the mode of delivery does not reduce mother to child transmission of hepatitis C virus infection, although avoidance of fetal scalp electrodes and other potential high risk procedures is recommended during pregnancy and delivery. Breast feeding has not been demonstrated to be a risk for mother-to-child transmission and avoidance of breast feeding is not recommended, although breast feeding with cracked or bleeding nipples is generally avoided. Safety of the currently available hepatitis C virus antivirals in pregnancy and breastfeeding has not yet been established.

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A Significant Sex—but Not Elective Cesarean Section—Effect on Mother‐to‐Child Transmission of Hepatitis C Virus Infection

The Journal of Infectious Diseases ◽

10.1086/497695 ◽

2005 ◽

Vol 192 (11) ◽

pp. 1872-1879 ◽

Cited By ~ 158

Author(s):

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Cesarean Section ◽

Elective Cesarean Section ◽

Mother To Child Transmission ◽

Hepatitis C Virus Infection ◽

Child Transmission ◽

Elective Cesarean ◽

Mother To Child

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The Timing of Mother-to-Child Transmission of Human Immunodeficiency Virus Infection and the Neurodevelopment of Children in Tanzania

The Pediatric Infectious Disease Journal ◽

10.1097/01.inf.0000195638.80578.e0 ◽

2006 ◽

Vol 25 (1) ◽

pp. 47-52 ◽

Cited By ~ 32

Author(s):

Nuala McGrath ◽

Wafaie W. Fawzi ◽

David Bellinger ◽

James Robins ◽

Gernard I. Msamanga ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Virus Infection ◽

Human Immunodeficiency Virus Infection ◽

Mother To Child Transmission ◽

Child Transmission ◽

Immunodeficiency Virus ◽

Mother To Child

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Hepatitis E Virus

10.1093/med/9780190604813.003.0006 ◽

2018 ◽

Author(s):

Lisa J. Krain ◽

Kenrad E. Nelson

Keyword(s):

Pregnant Women ◽

Hepatitis E Virus ◽

Standard Treatment ◽

Neonatal Period ◽

Hepatitis E ◽

Child Transmission ◽

The Past ◽

Maternal Illness ◽

Increased Risk ◽

Mother To Child

Hepatitis E virus (HEV) poses serious risks to pregnant women and their developing fetuses, including increased risk of pregnancy loss, stillbirth, preterm delivery, and early infant death. Supportive care is currently the standard treatment for pregnant women with HEV infection, but in some cases, ribavirin treatment or early delivery may be indicated. Infants born with acute HEV infection face increased risk of complications and death. Intensive monitoring and support may be required in the neonatal period, particularly for preterm infants. Infants who survive the early neonatal period are likely to recover fully and clear the virus. Immunoassays and molecular methods for diagnosis of HEV have improved markedly over the past decade. New HEV vaccines may provide an opportunity to prevent both maternal illness and mother-to-child transmission (vertical transmission) (MTCT).

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